Summary | |
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Symbol | MED23 |
Name | mediator complex subunit 23 |
Aliases | CRSP130; DRIP130; CRSP3; cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa; ARC130; CR ...... |
Chromosomal Location | 6q22.33-q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF11573 Mediator complex subunit 23 |
Function |
Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. |
Biological Process |
GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter |
Molecular Function |
GO:0003713 transcription coactivator activity |
Cellular Component |
GO:0005667 transcription factor complex |
KEGG | - |
Reactome |
R-HSA-1266738: Developmental Biology R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1989781: PPARA activates gene expression R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-381340: Transcriptional regulation of white adipocyte differentiation |
Summary | |
---|---|
Symbol | MED23 |
Name | mediator complex subunit 23 |
Aliases | CRSP130; DRIP130; CRSP3; cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa; ARC130; CR ...... |
Chromosomal Location | 6q22.33-q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MED23 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MED23 |
Name | mediator complex subunit 23 |
Aliases | CRSP130; DRIP130; CRSP3; cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa; ARC130; CR ...... |
Chromosomal Location | 6q22.33-q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MED23 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MED23 |
Name | mediator complex subunit 23 |
Aliases | CRSP130; DRIP130; CRSP3; cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa; ARC130; CR ...... |
Chromosomal Location | 6q22.33-q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MED23 in various data sets.
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Points in the above scatter plot represent the mutation difference of MED23 in various data sets.
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Summary | |
---|---|
Symbol | MED23 |
Name | mediator complex subunit 23 |
Aliases | CRSP130; DRIP130; CRSP3; cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa; ARC130; CR ...... |
Chromosomal Location | 6q22.33-q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MED23. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MED23 |
Name | mediator complex subunit 23 |
Aliases | CRSP130; DRIP130; CRSP3; cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa; ARC130; CR ...... |
Chromosomal Location | 6q22.33-q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MED23. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MED23. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MED23 |
Name | mediator complex subunit 23 |
Aliases | CRSP130; DRIP130; CRSP3; cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa; ARC130; CR ...... |
Chromosomal Location | 6q22.33-q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MED23. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MED23 |
Name | mediator complex subunit 23 |
Aliases | CRSP130; DRIP130; CRSP3; cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa; ARC130; CR ...... |
Chromosomal Location | 6q22.33-q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MED23 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MED23 |
Name | mediator complex subunit 23 |
Aliases | CRSP130; DRIP130; CRSP3; cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa; ARC130; CR ...... |
Chromosomal Location | 6q22.33-q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MED23 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MED23 |
Name | mediator complex subunit 23 |
Aliases | CRSP130; DRIP130; CRSP3; cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa; ARC130; CR ...... |
Chromosomal Location | 6q22.33-q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MED23 collected from DrugBank database. |
There is no record. |