Summary | |
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Symbol | MERTK |
Name | MER proto-oncogene, tyrosine kinase |
Aliases | RP38; c-Eyk; Tyro12; c-mer proto-oncogene tyrosine kinase; c-mer; MER receptor tyrosine kinase; STK kinase; ...... |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein |
Domain |
PF00041 Fibronectin type III domain PF00047 Immunoglobulin domain PF07714 Protein tyrosine kinase |
Function |
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. |
Biological Process |
GO:0001654 eye development GO:0001779 natural killer cell differentiation GO:0002521 leukocyte differentiation GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0006909 phagocytosis GO:0007283 spermatogenesis GO:0007423 sensory organ development GO:0007548 sex differentiation GO:0007596 blood coagulation GO:0007599 hemostasis GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0030098 lymphocyte differentiation GO:0030100 regulation of endocytosis GO:0030101 natural killer cell activation GO:0030168 platelet activation GO:0030540 female genitalia development GO:0031589 cell-substrate adhesion GO:0034446 substrate adhesion-dependent cell spreading GO:0043010 camera-type eye development GO:0043277 apoptotic cell clearance GO:0043491 protein kinase B signaling GO:0045807 positive regulation of endocytosis GO:0046660 female sex differentiation GO:0048232 male gamete generation GO:0048608 reproductive structure development GO:0048806 genitalia development GO:0050764 regulation of phagocytosis GO:0050766 positive regulation of phagocytosis GO:0050817 coagulation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050878 regulation of body fluid levels GO:0050900 leukocyte migration GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0060041 retina development in camera-type eye GO:0060068 vagina development GO:0060627 regulation of vesicle-mediated transport GO:0061458 reproductive system development GO:0071887 leukocyte apoptotic process GO:2000106 regulation of leukocyte apoptotic process GO:2000107 negative regulation of leukocyte apoptotic process |
Molecular Function |
GO:0004713 protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0019199 transmembrane receptor protein kinase activity |
Cellular Component |
GO:0001750 photoreceptor outer segment GO:0005929 cilium GO:0016028 rhabdomere GO:0031513 nonmotile primary cilium GO:0072372 primary cilium |
KEGG | - |
Reactome |
R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-109582: Hemostasis |
Summary | |
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Symbol | MERTK |
Name | MER proto-oncogene, tyrosine kinase |
Aliases | RP38; c-Eyk; Tyro12; c-mer proto-oncogene tyrosine kinase; c-mer; MER receptor tyrosine kinase; STK kinase; ...... |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MERTK and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between MERTK and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | MERTK |
Name | MER proto-oncogene, tyrosine kinase |
Aliases | RP38; c-Eyk; Tyro12; c-mer proto-oncogene tyrosine kinase; c-mer; MER receptor tyrosine kinase; STK kinase; ...... |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MERTK in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MERTK |
Name | MER proto-oncogene, tyrosine kinase |
Aliases | RP38; c-Eyk; Tyro12; c-mer proto-oncogene tyrosine kinase; c-mer; MER receptor tyrosine kinase; STK kinase; ...... |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MERTK in various data sets.
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Points in the above scatter plot represent the mutation difference of MERTK in various data sets.
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Summary | |
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Symbol | MERTK |
Name | MER proto-oncogene, tyrosine kinase |
Aliases | RP38; c-Eyk; Tyro12; c-mer proto-oncogene tyrosine kinase; c-mer; MER receptor tyrosine kinase; STK kinase; ...... |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MERTK. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MERTK |
Name | MER proto-oncogene, tyrosine kinase |
Aliases | RP38; c-Eyk; Tyro12; c-mer proto-oncogene tyrosine kinase; c-mer; MER receptor tyrosine kinase; STK kinase; ...... |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MERTK. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MERTK. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MERTK |
Name | MER proto-oncogene, tyrosine kinase |
Aliases | RP38; c-Eyk; Tyro12; c-mer proto-oncogene tyrosine kinase; c-mer; MER receptor tyrosine kinase; STK kinase; ...... |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MERTK. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MERTK |
Name | MER proto-oncogene, tyrosine kinase |
Aliases | RP38; c-Eyk; Tyro12; c-mer proto-oncogene tyrosine kinase; c-mer; MER receptor tyrosine kinase; STK kinase; ...... |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MERTK expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MERTK |
Name | MER proto-oncogene, tyrosine kinase |
Aliases | RP38; c-Eyk; Tyro12; c-mer proto-oncogene tyrosine kinase; c-mer; MER receptor tyrosine kinase; STK kinase; ...... |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MERTK and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MERTK |
Name | MER proto-oncogene, tyrosine kinase |
Aliases | RP38; c-Eyk; Tyro12; c-mer proto-oncogene tyrosine kinase; c-mer; MER receptor tyrosine kinase; STK kinase; ...... |
Chromosomal Location | 2q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MERTK collected from DrugBank database. |
Details on drugs targeting MERTK.
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