Summary | |
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Symbol | MFAP2 |
Name | microfibrillar-associated protein 2 |
Aliases | MAGP; MAGP-1; MAGP1; microfibril-associated glycoprotein 1; MFAP-2 |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix. |
Domain |
PF05507 Microfibril-associated glycoprotein (MAGP) PF01549 ShK domain-like |
Function |
Component of the elastin-associated microfibrils. |
Biological Process |
GO:0001654 eye development GO:0007423 sensory organ development GO:0009791 post-embryonic development GO:0009886 post-embryonic animal morphogenesis GO:0030198 extracellular matrix organization GO:0043062 extracellular structure organization GO:0048048 embryonic eye morphogenesis GO:0048050 post-embryonic eye morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048563 post-embryonic animal organ morphogenesis GO:0048568 embryonic organ development GO:0048569 post-embryonic animal organ development GO:0048592 eye morphogenesis GO:0090596 sensory organ morphogenesis |
Molecular Function | - |
Cellular Component |
GO:0001527 microfibril GO:0005578 proteinaceous extracellular matrix GO:0043205 fibril GO:0044420 extracellular matrix component |
KEGG | - |
Reactome |
R-HSA-1566948: Elastic fibre formation R-HSA-1474244: Extracellular matrix organization R-HSA-2129379: Molecules associated with elastic fibres |
Summary | |
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Symbol | MFAP2 |
Name | microfibrillar-associated protein 2 |
Aliases | MAGP; MAGP-1; MAGP1; microfibril-associated glycoprotein 1; MFAP-2 |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MFAP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MFAP2 |
Name | microfibrillar-associated protein 2 |
Aliases | MAGP; MAGP-1; MAGP1; microfibril-associated glycoprotein 1; MFAP-2 |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MFAP2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MFAP2 |
Name | microfibrillar-associated protein 2 |
Aliases | MAGP; MAGP-1; MAGP1; microfibril-associated glycoprotein 1; MFAP-2 |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MFAP2 in various data sets.
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Points in the above scatter plot represent the mutation difference of MFAP2 in various data sets.
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Summary | |
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Symbol | MFAP2 |
Name | microfibrillar-associated protein 2 |
Aliases | MAGP; MAGP-1; MAGP1; microfibril-associated glycoprotein 1; MFAP-2 |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MFAP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MFAP2 |
Name | microfibrillar-associated protein 2 |
Aliases | MAGP; MAGP-1; MAGP1; microfibril-associated glycoprotein 1; MFAP-2 |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MFAP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MFAP2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MFAP2 |
Name | microfibrillar-associated protein 2 |
Aliases | MAGP; MAGP-1; MAGP1; microfibril-associated glycoprotein 1; MFAP-2 |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MFAP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MFAP2 |
Name | microfibrillar-associated protein 2 |
Aliases | MAGP; MAGP-1; MAGP1; microfibril-associated glycoprotein 1; MFAP-2 |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MFAP2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MFAP2 |
Name | microfibrillar-associated protein 2 |
Aliases | MAGP; MAGP-1; MAGP1; microfibril-associated glycoprotein 1; MFAP-2 |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MFAP2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MFAP2 |
Name | microfibrillar-associated protein 2 |
Aliases | MAGP; MAGP-1; MAGP1; microfibril-associated glycoprotein 1; MFAP-2 |
Chromosomal Location | 1p36.1-p35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MFAP2 collected from DrugBank database. |
There is no record. |