Summary | |
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Symbol | MFAP4 |
Name | microfibrillar-associated protein 4 |
Aliases | microfibril-associated glycoprotein 4 |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix |
Domain |
PF00147 Fibrinogen beta and gamma chains |
Function |
Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance (PubMed:26601954). |
Biological Process |
GO:0009314 response to radiation GO:0009411 response to UV GO:0009416 response to light stimulus GO:0009650 UV protection GO:0010224 response to UV-B GO:0010712 regulation of collagen metabolic process GO:0030198 extracellular matrix organization GO:0032963 collagen metabolic process GO:0034644 cellular response to UV GO:0043062 extracellular structure organization GO:0043206 extracellular fibril organization GO:0044236 multicellular organism metabolic process GO:0044246 regulation of multicellular organismal metabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0048251 elastic fiber assembly GO:0071214 cellular response to abiotic stimulus GO:0071478 cellular response to radiation GO:0071482 cellular response to light stimulus GO:0071493 cellular response to UV-B GO:0085029 extracellular matrix assembly GO:0097435 fibril organization |
Molecular Function | - |
Cellular Component |
GO:0001527 microfibril GO:0005578 proteinaceous extracellular matrix GO:0043205 fibril GO:0044420 extracellular matrix component GO:0071953 elastic fiber |
KEGG | - |
Reactome |
R-HSA-1566948: Elastic fibre formation R-HSA-1474244: Extracellular matrix organization R-HSA-2129379: Molecules associated with elastic fibres |
Summary | |
---|---|
Symbol | MFAP4 |
Name | microfibrillar-associated protein 4 |
Aliases | microfibril-associated glycoprotein 4 |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MFAP4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MFAP4 |
Name | microfibrillar-associated protein 4 |
Aliases | microfibril-associated glycoprotein 4 |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MFAP4 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | MFAP4 |
Name | microfibrillar-associated protein 4 |
Aliases | microfibril-associated glycoprotein 4 |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MFAP4 in various data sets.
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Points in the above scatter plot represent the mutation difference of MFAP4 in various data sets.
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Summary | |
---|---|
Symbol | MFAP4 |
Name | microfibrillar-associated protein 4 |
Aliases | microfibril-associated glycoprotein 4 |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MFAP4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MFAP4 |
Name | microfibrillar-associated protein 4 |
Aliases | microfibril-associated glycoprotein 4 |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MFAP4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MFAP4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MFAP4 |
Name | microfibrillar-associated protein 4 |
Aliases | microfibril-associated glycoprotein 4 |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MFAP4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MFAP4 |
Name | microfibrillar-associated protein 4 |
Aliases | microfibril-associated glycoprotein 4 |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MFAP4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MFAP4 |
Name | microfibrillar-associated protein 4 |
Aliases | microfibril-associated glycoprotein 4 |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MFAP4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |