Summary | |
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Symbol | MICB |
Name | MHC class I polypeptide-related sequence B |
Aliases | PERB11.2; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I-like molecule PERB11.2 ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Note=Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. |
Domain |
PF07654 Immunoglobulin C1-set domain PF00129 Class I Histocompatibility antigen |
Function |
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. |
Biological Process |
GO:0001101 response to acid chemical GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001913 T cell mediated cytotoxicity GO:0002228 natural killer cell mediated immunity GO:0002250 adaptive immune response GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002683 negative regulation of immune system process GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0002831 regulation of response to biotic stimulus GO:0002832 negative regulation of response to biotic stimulus GO:0006979 response to oxidative stress GO:0007159 leukocyte cell-cell adhesion GO:0009266 response to temperature stimulus GO:0009408 response to heat GO:0009615 response to virus GO:0019835 cytolysis GO:0019882 antigen processing and presentation GO:0031348 negative regulation of defense response GO:0032102 negative regulation of response to external stimulus GO:0032526 response to retinoic acid GO:0042110 T cell activation GO:0042267 natural killer cell mediated cytotoxicity GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0046629 gamma-delta T cell activation GO:0048525 negative regulation of viral process GO:0050687 negative regulation of defense response to virus GO:0050688 regulation of defense response to virus GO:0050689 negative regulation of defense response to virus by host GO:0050691 regulation of defense response to virus by host GO:0050792 regulation of viral process GO:0051607 defense response to virus GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071593 lymphocyte aggregation GO:0098542 defense response to other organism |
Molecular Function |
GO:0003823 antigen binding GO:0046703 natural killer cell lectin-like receptor binding |
Cellular Component | - |
KEGG |
hsa04650 Natural killer cell mediated cytotoxicity |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Summary | |
---|---|
Symbol | MICB |
Name | MHC class I polypeptide-related sequence B |
Aliases | PERB11.2; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I-like molecule PERB11.2 ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MICB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between MICB and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | MICB |
Name | MHC class I polypeptide-related sequence B |
Aliases | PERB11.2; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I-like molecule PERB11.2 ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MICB in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MICB |
Name | MHC class I polypeptide-related sequence B |
Aliases | PERB11.2; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I-like molecule PERB11.2 ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MICB in various data sets.
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Points in the above scatter plot represent the mutation difference of MICB in various data sets.
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Summary | |
---|---|
Symbol | MICB |
Name | MHC class I polypeptide-related sequence B |
Aliases | PERB11.2; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I-like molecule PERB11.2 ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MICB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MICB |
Name | MHC class I polypeptide-related sequence B |
Aliases | PERB11.2; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I-like molecule PERB11.2 ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MICB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MICB. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MICB |
Name | MHC class I polypeptide-related sequence B |
Aliases | PERB11.2; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I-like molecule PERB11.2 ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MICB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MICB |
Name | MHC class I polypeptide-related sequence B |
Aliases | PERB11.2; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I-like molecule PERB11.2 ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MICB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MICB |
Name | MHC class I polypeptide-related sequence B |
Aliases | PERB11.2; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I-like molecule PERB11.2 ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MICB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MICB |
Name | MHC class I polypeptide-related sequence B |
Aliases | PERB11.2; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I-like molecule PERB11.2 ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MICB collected from DrugBank database. |
There is no record. |