Summary | |
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Symbol | MIF |
Name | macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
Aliases | GLIF; MMIF; L-dopachrome isomerase; phenylpyruvate tautomerase; Glycosylation-inhibiting factor; Macrophage ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted Cytoplasm Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. |
Domain |
PF01187 Macrophage migration inhibitory factor (MIF) |
Function |
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. |
Biological Process |
GO:0001516 prostaglandin biosynthetic process GO:0001776 leukocyte homeostasis GO:0001782 B cell homeostasis GO:0001783 B cell apoptotic process GO:0001819 positive regulation of cytokine production GO:0002237 response to molecule of bacterial origin GO:0002260 lymphocyte homeostasis GO:0002274 myeloid leukocyte activation GO:0002367 cytokine production involved in immune response GO:0002440 production of molecular mediator of immune response GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002718 regulation of cytokine production involved in immune response GO:0002720 positive regulation of cytokine production involved in immune response GO:0002831 regulation of response to biotic stimulus GO:0002833 positive regulation of response to biotic stimulus GO:0002901 mature B cell apoptotic process GO:0002902 regulation of B cell apoptotic process GO:0002903 negative regulation of B cell apoptotic process GO:0002905 regulation of mature B cell apoptotic process GO:0002906 negative regulation of mature B cell apoptotic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006636 unsaturated fatty acid biosynthetic process GO:0006690 icosanoid metabolic process GO:0006692 prostanoid metabolic process GO:0006693 prostaglandin metabolic process GO:0006820 anion transport GO:0006869 lipid transport GO:0007050 cell cycle arrest GO:0007568 aging GO:0007569 cell aging GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0009306 protein secretion GO:0010737 protein kinase A signaling GO:0010738 regulation of protein kinase A signaling GO:0010739 positive regulation of protein kinase A signaling GO:0010876 lipid localization GO:0010948 negative regulation of cell cycle process GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015732 prostaglandin transport GO:0015908 fatty acid transport GO:0015909 long-chain fatty acid transport GO:0016053 organic acid biosynthetic process GO:0018105 peptidyl-serine phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018209 peptidyl-serine modification GO:0018212 peptidyl-tyrosine modification GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0030888 regulation of B cell proliferation GO:0030890 positive regulation of B cell proliferation GO:0031663 lipopolysaccharide-mediated signaling pathway GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway GO:0032103 positive regulation of response to external stimulus GO:0032303 regulation of icosanoid secretion GO:0032305 positive regulation of icosanoid secretion GO:0032306 regulation of prostaglandin secretion GO:0032308 positive regulation of prostaglandin secretion GO:0032309 icosanoid secretion GO:0032310 prostaglandin secretion GO:0032368 regulation of lipid transport GO:0032370 positive regulation of lipid transport GO:0032496 response to lipopolysaccharide GO:0032602 chemokine production GO:0032642 regulation of chemokine production GO:0032722 positive regulation of chemokine production GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033028 myeloid cell apoptotic process GO:0033032 regulation of myeloid cell apoptotic process GO:0033033 negative regulation of myeloid cell apoptotic process GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033559 unsaturated fatty acid metabolic process GO:0033674 positive regulation of kinase activity GO:0042100 B cell proliferation GO:0042113 B cell activation GO:0042116 macrophage activation GO:0042770 signal transduction in response to DNA damage GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0043030 regulation of macrophage activation GO:0043270 positive regulation of ion transport GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0044070 regulation of anion transport GO:0044283 small molecule biosynthetic process GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045860 positive regulation of protein kinase activity GO:0046394 carboxylic acid biosynthetic process GO:0046456 icosanoid biosynthetic process GO:0046457 prostanoid biosynthetic process GO:0046651 lymphocyte proliferation GO:0046942 carboxylic acid transport GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048146 positive regulation of fibroblast proliferation GO:0048872 homeostasis of number of cells GO:0050482 arachidonic acid secretion GO:0050663 cytokine secretion GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050871 positive regulation of B cell activation GO:0050900 leukocyte migration GO:0050918 positive chemotaxis GO:0051047 positive regulation of secretion GO:0051222 positive regulation of protein transport GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0061078 positive regulation of prostaglandin secretion involved in immune response GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061082 myeloid leukocyte cytokine production GO:0070206 protein trimerization GO:0070207 protein homotrimerization GO:0070227 lymphocyte apoptotic process GO:0070228 regulation of lymphocyte apoptotic process GO:0070229 negative regulation of lymphocyte apoptotic process GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071156 regulation of cell cycle arrest GO:0071157 negative regulation of cell cycle arrest GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071396 cellular response to lipid GO:0071715 icosanoid transport GO:0071887 leukocyte apoptotic process GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072330 monocarboxylic acid biosynthetic process GO:0072331 signal transduction by p53 class mediator GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072567 chemokine (C-X-C motif) ligand 2 production GO:0090237 regulation of arachidonic acid secretion GO:0090238 positive regulation of arachidonic acid secretion GO:0090323 prostaglandin secretion involved in immune response GO:0090342 regulation of cell aging GO:0090344 negative regulation of cell aging GO:0097193 intrinsic apoptotic signaling pathway GO:1901796 regulation of signal transduction by p53 class mediator GO:1901797 negative regulation of signal transduction by p53 class mediator GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902532 negative regulation of intracellular signal transduction GO:1903532 positive regulation of secretion by cell GO:1903793 positive regulation of anion transport GO:1903963 arachidonate transport GO:1904951 positive regulation of establishment of protein localization GO:2000106 regulation of leukocyte apoptotic process GO:2000107 negative regulation of leukocyte apoptotic process GO:2000191 regulation of fatty acid transport GO:2000193 positive regulation of fatty acid transport GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0004167 dopachrome isomerase activity GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0016853 isomerase activity GO:0016860 intramolecular oxidoreductase activity GO:0016862 intramolecular oxidoreductase activity, interconverting keto- and enol-groups GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds GO:0042056 chemoattractant activity GO:0050178 phenylpyruvate tautomerase activity |
Cellular Component |
GO:0043209 myelin sheath |
KEGG |
hsa00350 Tyrosine metabolism hsa00360 Phenylalanine metabolism |
Reactome |
R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation |
Summary | |
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Symbol | MIF |
Name | macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
Aliases | GLIF; MMIF; L-dopachrome isomerase; phenylpyruvate tautomerase; Glycosylation-inhibiting factor; Macrophage ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MIF and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between MIF and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | MIF |
Name | macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
Aliases | GLIF; MMIF; L-dopachrome isomerase; phenylpyruvate tautomerase; Glycosylation-inhibiting factor; Macrophage ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MIF in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MIF |
Name | macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
Aliases | GLIF; MMIF; L-dopachrome isomerase; phenylpyruvate tautomerase; Glycosylation-inhibiting factor; Macrophage ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MIF in various data sets.
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Points in the above scatter plot represent the mutation difference of MIF in various data sets.
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Summary | |
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Symbol | MIF |
Name | macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
Aliases | GLIF; MMIF; L-dopachrome isomerase; phenylpyruvate tautomerase; Glycosylation-inhibiting factor; Macrophage ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MIF. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MIF |
Name | macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
Aliases | GLIF; MMIF; L-dopachrome isomerase; phenylpyruvate tautomerase; Glycosylation-inhibiting factor; Macrophage ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MIF. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MIF. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MIF |
Name | macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
Aliases | GLIF; MMIF; L-dopachrome isomerase; phenylpyruvate tautomerase; Glycosylation-inhibiting factor; Macrophage ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MIF. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MIF |
Name | macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
Aliases | GLIF; MMIF; L-dopachrome isomerase; phenylpyruvate tautomerase; Glycosylation-inhibiting factor; Macrophage ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MIF expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MIF |
Name | macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
Aliases | GLIF; MMIF; L-dopachrome isomerase; phenylpyruvate tautomerase; Glycosylation-inhibiting factor; Macrophage ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MIF and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MIF |
Name | macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
Aliases | GLIF; MMIF; L-dopachrome isomerase; phenylpyruvate tautomerase; Glycosylation-inhibiting factor; Macrophage ...... |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MIF collected from DrugBank database. |
Details on drugs targeting MIF.
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