Summary | |
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Symbol | MITF |
Name | microphthalmia-associated transcription factor |
Aliases | MI; bHLHe32; homolog of mouse microphthalmia; WS2A; WS2; Waardenburg syndrome, type 2A; class E basic helix- ...... |
Chromosomal Location | 3p14.1-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF11851 Domain of unknown function (DUF3371) PF00010 Helix-loop-helix DNA-binding domain PF15951 MITF/TFEB/TFEC/TFE3 N-terminus |
Function |
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. |
Biological Process |
GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002761 regulation of myeloid leukocyte differentiation GO:0006352 DNA-templated transcription, initiation GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0030099 myeloid cell differentiation GO:0030316 osteoclast differentiation GO:0030318 melanocyte differentiation GO:0031334 positive regulation of protein complex assembly GO:0043254 regulation of protein complex assembly GO:0043473 pigmentation GO:0044089 positive regulation of cellular component biogenesis GO:0045637 regulation of myeloid cell differentiation GO:0045670 regulation of osteoclast differentiation GO:0048066 developmental pigmentation GO:0050900 leukocyte migration GO:0050931 pigment cell differentiation GO:0097529 myeloid leukocyte migration GO:0097531 mast cell migration GO:1902105 regulation of leukocyte differentiation GO:1903706 regulation of hemopoiesis GO:2000142 regulation of DNA-templated transcription, initiation GO:2000144 positive regulation of DNA-templated transcription, initiation |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding |
Cellular Component | - |
KEGG |
hsa04380 Osteoclast differentiation hsa04916 Melanogenesis |
Reactome |
R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3232118: SUMOylation of transcription factors |
Summary | |
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Symbol | MITF |
Name | microphthalmia-associated transcription factor |
Aliases | MI; bHLHe32; homolog of mouse microphthalmia; WS2A; WS2; Waardenburg syndrome, type 2A; class E basic helix- ...... |
Chromosomal Location | 3p14.1-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MITF and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between MITF and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | MITF |
Name | microphthalmia-associated transcription factor |
Aliases | MI; bHLHe32; homolog of mouse microphthalmia; WS2A; WS2; Waardenburg syndrome, type 2A; class E basic helix- ...... |
Chromosomal Location | 3p14.1-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MITF in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | MITF |
Name | microphthalmia-associated transcription factor |
Aliases | MI; bHLHe32; homolog of mouse microphthalmia; WS2A; WS2; Waardenburg syndrome, type 2A; class E basic helix- ...... |
Chromosomal Location | 3p14.1-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MITF in various data sets.
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Points in the above scatter plot represent the mutation difference of MITF in various data sets.
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Summary | |
---|---|
Symbol | MITF |
Name | microphthalmia-associated transcription factor |
Aliases | MI; bHLHe32; homolog of mouse microphthalmia; WS2A; WS2; Waardenburg syndrome, type 2A; class E basic helix- ...... |
Chromosomal Location | 3p14.1-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MITF. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MITF |
Name | microphthalmia-associated transcription factor |
Aliases | MI; bHLHe32; homolog of mouse microphthalmia; WS2A; WS2; Waardenburg syndrome, type 2A; class E basic helix- ...... |
Chromosomal Location | 3p14.1-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MITF. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MITF. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MITF |
Name | microphthalmia-associated transcription factor |
Aliases | MI; bHLHe32; homolog of mouse microphthalmia; WS2A; WS2; Waardenburg syndrome, type 2A; class E basic helix- ...... |
Chromosomal Location | 3p14.1-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MITF. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MITF |
Name | microphthalmia-associated transcription factor |
Aliases | MI; bHLHe32; homolog of mouse microphthalmia; WS2A; WS2; Waardenburg syndrome, type 2A; class E basic helix- ...... |
Chromosomal Location | 3p14.1-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MITF expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MITF |
Name | microphthalmia-associated transcription factor |
Aliases | MI; bHLHe32; homolog of mouse microphthalmia; WS2A; WS2; Waardenburg syndrome, type 2A; class E basic helix- ...... |
Chromosomal Location | 3p14.1-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MITF and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MITF |
Name | microphthalmia-associated transcription factor |
Aliases | MI; bHLHe32; homolog of mouse microphthalmia; WS2A; WS2; Waardenburg syndrome, type 2A; class E basic helix- ...... |
Chromosomal Location | 3p14.1-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MITF collected from DrugBank database. |
There is no record. |