Summary | |
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Symbol | MOAP1 |
Name | modulator of apoptosis 1 |
Aliases | MAP-1; PNMA4; paraneoplastic Ma antigen family member 4; paraneoplastic antigen Ma4; paraneoplastic antigen ...... |
Chromosomal Location | 14q32.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF14893 PNMA |
Function |
Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. |
Biological Process |
GO:0001836 release of cytochrome c from mitochondria GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0006839 mitochondrial transport GO:0007006 mitochondrial membrane organization GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008637 apoptotic mitochondrial changes GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0035794 positive regulation of mitochondrial membrane permeability GO:0038034 signal transduction in absence of ligand GO:0046902 regulation of mitochondrial membrane permeability GO:0051204 protein insertion into mitochondrial membrane GO:0051205 protein insertion into membrane GO:0070585 protein localization to mitochondrion GO:0072655 establishment of protein localization to mitochondrion GO:0072657 protein localization to membrane GO:0090150 establishment of protein localization to membrane GO:0090199 regulation of release of cytochrome c from mitochondria GO:0090200 positive regulation of release of cytochrome c from mitochondria GO:0090559 regulation of membrane permeability GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0097193 intrinsic apoptotic signaling pathway GO:0097345 mitochondrial outer membrane permeabilization GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway |
Molecular Function |
GO:0031625 ubiquitin protein ligase binding GO:0044389 ubiquitin-like protein ligase binding |
Cellular Component |
GO:0005741 mitochondrial outer membrane GO:0019867 outer membrane GO:0031968 organelle outer membrane |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | MOAP1 |
Name | modulator of apoptosis 1 |
Aliases | MAP-1; PNMA4; paraneoplastic Ma antigen family member 4; paraneoplastic antigen Ma4; paraneoplastic antigen ...... |
Chromosomal Location | 14q32.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MOAP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MOAP1 |
Name | modulator of apoptosis 1 |
Aliases | MAP-1; PNMA4; paraneoplastic Ma antigen family member 4; paraneoplastic antigen Ma4; paraneoplastic antigen ...... |
Chromosomal Location | 14q32.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MOAP1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | MOAP1 |
Name | modulator of apoptosis 1 |
Aliases | MAP-1; PNMA4; paraneoplastic Ma antigen family member 4; paraneoplastic antigen Ma4; paraneoplastic antigen ...... |
Chromosomal Location | 14q32.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MOAP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of MOAP1 in various data sets.
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Summary | |
---|---|
Symbol | MOAP1 |
Name | modulator of apoptosis 1 |
Aliases | MAP-1; PNMA4; paraneoplastic Ma antigen family member 4; paraneoplastic antigen Ma4; paraneoplastic antigen ...... |
Chromosomal Location | 14q32.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MOAP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MOAP1 |
Name | modulator of apoptosis 1 |
Aliases | MAP-1; PNMA4; paraneoplastic Ma antigen family member 4; paraneoplastic antigen Ma4; paraneoplastic antigen ...... |
Chromosomal Location | 14q32.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MOAP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MOAP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MOAP1 |
Name | modulator of apoptosis 1 |
Aliases | MAP-1; PNMA4; paraneoplastic Ma antigen family member 4; paraneoplastic antigen Ma4; paraneoplastic antigen ...... |
Chromosomal Location | 14q32.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MOAP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MOAP1 |
Name | modulator of apoptosis 1 |
Aliases | MAP-1; PNMA4; paraneoplastic Ma antigen family member 4; paraneoplastic antigen Ma4; paraneoplastic antigen ...... |
Chromosomal Location | 14q32.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MOAP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MOAP1 |
Name | modulator of apoptosis 1 |
Aliases | MAP-1; PNMA4; paraneoplastic Ma antigen family member 4; paraneoplastic antigen Ma4; paraneoplastic antigen ...... |
Chromosomal Location | 14q32.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MOAP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MOAP1 |
Name | modulator of apoptosis 1 |
Aliases | MAP-1; PNMA4; paraneoplastic Ma antigen family member 4; paraneoplastic antigen Ma4; paraneoplastic antigen ...... |
Chromosomal Location | 14q32.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MOAP1 collected from DrugBank database. |
There is no record. |