Summary | |
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Symbol | MOV10L1 |
Name | Mov10 RISC complex RNA helicase like 1 |
Aliases | DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. |
Domain | - |
Function |
ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. |
Biological Process |
GO:0006304 DNA modification GO:0006305 DNA alkylation GO:0006306 DNA methylation GO:0007126 meiotic nuclear division GO:0007127 meiosis I GO:0007140 male meiosis GO:0007141 male meiosis I GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0022412 cellular process involved in reproduction in multicellular organism GO:0032259 methylation GO:0034587 piRNA metabolic process GO:0043046 DNA methylation involved in gamete generation GO:0043414 macromolecule methylation GO:0044728 DNA methylation or demethylation GO:0048232 male gamete generation GO:0051321 meiotic cell cycle GO:1903046 meiotic cell cycle process |
Molecular Function |
GO:0000287 magnesium ion binding GO:0003724 RNA helicase activity GO:0004004 ATP-dependent RNA helicase activity GO:0004386 helicase activity GO:0008026 ATP-dependent helicase activity GO:0008186 RNA-dependent ATPase activity GO:0016887 ATPase activity GO:0042623 ATPase activity, coupled GO:0070035 purine NTP-dependent helicase activity |
Cellular Component |
GO:0035770 ribonucleoprotein granule GO:0036464 cytoplasmic ribonucleoprotein granule GO:0043186 P granule GO:0045495 pole plasm GO:0060293 germ plasm GO:0071546 pi-body |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-211000: Gene Silencing by RNA R-HSA-5601884: PIWI-interacting RNA (piRNA) biogenesis |
Summary | |
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Symbol | MOV10L1 |
Name | Mov10 RISC complex RNA helicase like 1 |
Aliases | DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MOV10L1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MOV10L1 |
Name | Mov10 RISC complex RNA helicase like 1 |
Aliases | DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MOV10L1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MOV10L1 |
Name | Mov10 RISC complex RNA helicase like 1 |
Aliases | DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MOV10L1 in various data sets.
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Points in the above scatter plot represent the mutation difference of MOV10L1 in various data sets.
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Summary | |
---|---|
Symbol | MOV10L1 |
Name | Mov10 RISC complex RNA helicase like 1 |
Aliases | DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MOV10L1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MOV10L1 |
Name | Mov10 RISC complex RNA helicase like 1 |
Aliases | DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MOV10L1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MOV10L1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MOV10L1 |
Name | Mov10 RISC complex RNA helicase like 1 |
Aliases | DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MOV10L1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MOV10L1 |
Name | Mov10 RISC complex RNA helicase like 1 |
Aliases | DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MOV10L1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MOV10L1 |
Name | Mov10 RISC complex RNA helicase like 1 |
Aliases | DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MOV10L1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MOV10L1 |
Name | Mov10 RISC complex RNA helicase like 1 |
Aliases | DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ...... |
Chromosomal Location | 22q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MOV10L1 collected from DrugBank database. |
There is no record. |