Summary | |
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Symbol | MPDU1 |
Name | mannose-P-dolichol utilization defect 1 |
Aliases | SL15; Lec35; PQLC5; CDGIf; HBEBP2BPA; My008; PP3958; HBeAg-binding protein 2 binding protein A; suppressor o ...... |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein |
Domain |
PF04193 PQ loop repeat |
Function |
Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors. |
Biological Process |
GO:0006457 protein folding GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0006490 oligosaccharide-lipid intermediate biosynthetic process GO:0009311 oligosaccharide metabolic process GO:0009312 oligosaccharide biosynthetic process GO:0016051 carbohydrate biosynthetic process GO:0044723 single-organism carbohydrate metabolic process |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-446193: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification |
Summary | |
---|---|
Symbol | MPDU1 |
Name | mannose-P-dolichol utilization defect 1 |
Aliases | SL15; Lec35; PQLC5; CDGIf; HBEBP2BPA; My008; PP3958; HBeAg-binding protein 2 binding protein A; suppressor o ...... |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MPDU1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MPDU1 |
Name | mannose-P-dolichol utilization defect 1 |
Aliases | SL15; Lec35; PQLC5; CDGIf; HBEBP2BPA; My008; PP3958; HBeAg-binding protein 2 binding protein A; suppressor o ...... |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MPDU1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | MPDU1 |
Name | mannose-P-dolichol utilization defect 1 |
Aliases | SL15; Lec35; PQLC5; CDGIf; HBEBP2BPA; My008; PP3958; HBeAg-binding protein 2 binding protein A; suppressor o ...... |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MPDU1 in various data sets.
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Points in the above scatter plot represent the mutation difference of MPDU1 in various data sets.
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Summary | |
---|---|
Symbol | MPDU1 |
Name | mannose-P-dolichol utilization defect 1 |
Aliases | SL15; Lec35; PQLC5; CDGIf; HBEBP2BPA; My008; PP3958; HBeAg-binding protein 2 binding protein A; suppressor o ...... |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MPDU1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MPDU1 |
Name | mannose-P-dolichol utilization defect 1 |
Aliases | SL15; Lec35; PQLC5; CDGIf; HBEBP2BPA; My008; PP3958; HBeAg-binding protein 2 binding protein A; suppressor o ...... |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MPDU1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MPDU1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MPDU1 |
Name | mannose-P-dolichol utilization defect 1 |
Aliases | SL15; Lec35; PQLC5; CDGIf; HBEBP2BPA; My008; PP3958; HBeAg-binding protein 2 binding protein A; suppressor o ...... |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MPDU1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MPDU1 |
Name | mannose-P-dolichol utilization defect 1 |
Aliases | SL15; Lec35; PQLC5; CDGIf; HBEBP2BPA; My008; PP3958; HBeAg-binding protein 2 binding protein A; suppressor o ...... |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MPDU1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MPDU1 |
Name | mannose-P-dolichol utilization defect 1 |
Aliases | SL15; Lec35; PQLC5; CDGIf; HBEBP2BPA; My008; PP3958; HBeAg-binding protein 2 binding protein A; suppressor o ...... |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MPDU1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MPDU1 |
Name | mannose-P-dolichol utilization defect 1 |
Aliases | SL15; Lec35; PQLC5; CDGIf; HBEBP2BPA; My008; PP3958; HBeAg-binding protein 2 binding protein A; suppressor o ...... |
Chromosomal Location | 17p13.1-p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MPDU1 collected from DrugBank database. |
There is no record. |