Summary | |
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Symbol | MPRIP |
Name | myosin phosphatase Rho interacting protein |
Aliases | RHOIP3; M-RIP; p116Rip; Rho interacting protein 3; MRIP; Rho-interacting protein 3; Myosin phosphatase Rho-i ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton Note=Colocalizes with F-actin. |
Domain |
PF00169 PH domain |
Function |
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. |
Biological Process | - |
Molecular Function |
GO:0003779 actin binding GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005913 cell-cell adherens junction GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0015629 actin cytoskeleton GO:0030055 cell-substrate junction |
KEGG | - |
Reactome |
R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-6802957: Oncogenic MAPK signaling R-HSA-6802952: Signaling by BRAF and RAF fusions |
Summary | |
---|---|
Symbol | MPRIP |
Name | myosin phosphatase Rho interacting protein |
Aliases | RHOIP3; M-RIP; p116Rip; Rho interacting protein 3; MRIP; Rho-interacting protein 3; Myosin phosphatase Rho-i ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MPRIP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MPRIP |
Name | myosin phosphatase Rho interacting protein |
Aliases | RHOIP3; M-RIP; p116Rip; Rho interacting protein 3; MRIP; Rho-interacting protein 3; Myosin phosphatase Rho-i ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MPRIP in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MPRIP |
Name | myosin phosphatase Rho interacting protein |
Aliases | RHOIP3; M-RIP; p116Rip; Rho interacting protein 3; MRIP; Rho-interacting protein 3; Myosin phosphatase Rho-i ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MPRIP in various data sets.
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Points in the above scatter plot represent the mutation difference of MPRIP in various data sets.
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Summary | |
---|---|
Symbol | MPRIP |
Name | myosin phosphatase Rho interacting protein |
Aliases | RHOIP3; M-RIP; p116Rip; Rho interacting protein 3; MRIP; Rho-interacting protein 3; Myosin phosphatase Rho-i ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MPRIP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MPRIP |
Name | myosin phosphatase Rho interacting protein |
Aliases | RHOIP3; M-RIP; p116Rip; Rho interacting protein 3; MRIP; Rho-interacting protein 3; Myosin phosphatase Rho-i ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MPRIP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MPRIP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MPRIP |
Name | myosin phosphatase Rho interacting protein |
Aliases | RHOIP3; M-RIP; p116Rip; Rho interacting protein 3; MRIP; Rho-interacting protein 3; Myosin phosphatase Rho-i ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MPRIP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MPRIP |
Name | myosin phosphatase Rho interacting protein |
Aliases | RHOIP3; M-RIP; p116Rip; Rho interacting protein 3; MRIP; Rho-interacting protein 3; Myosin phosphatase Rho-i ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MPRIP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MPRIP |
Name | myosin phosphatase Rho interacting protein |
Aliases | RHOIP3; M-RIP; p116Rip; Rho interacting protein 3; MRIP; Rho-interacting protein 3; Myosin phosphatase Rho-i ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MPRIP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MPRIP |
Name | myosin phosphatase Rho interacting protein |
Aliases | RHOIP3; M-RIP; p116Rip; Rho interacting protein 3; MRIP; Rho-interacting protein 3; Myosin phosphatase Rho-i ...... |
Chromosomal Location | 17p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MPRIP collected from DrugBank database. |
There is no record. |