Summary | |
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Symbol | MPV17L |
Name | MPV17 mitochondrial membrane protein-like |
Aliases | FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Peroxisome membrane Multi-pass membrane protein. |
Domain |
PF04117 Mpv17 / PMP22 family |
Function |
Isoform 1 participates in reactive oxygen species metablism by up- or down-regulation of the genes of antioxidant enzymes. |
Biological Process |
GO:0006839 mitochondrial transport GO:0007006 mitochondrial membrane organization GO:0008637 apoptotic mitochondrial changes GO:0010310 regulation of hydrogen peroxide metabolic process GO:0010639 negative regulation of organelle organization GO:0010727 negative regulation of hydrogen peroxide metabolic process GO:0010728 regulation of hydrogen peroxide biosynthetic process GO:0010730 negative regulation of hydrogen peroxide biosynthetic process GO:0010821 regulation of mitochondrion organization GO:0010823 negative regulation of mitochondrion organization GO:0035794 positive regulation of mitochondrial membrane permeability GO:0042743 hydrogen peroxide metabolic process GO:0046902 regulation of mitochondrial membrane permeability GO:0050665 hydrogen peroxide biosynthetic process GO:0051051 negative regulation of transport GO:0072593 reactive oxygen species metabolic process GO:0090559 regulation of membrane permeability GO:0097345 mitochondrial outer membrane permeabilization GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903427 negative regulation of reactive oxygen species biosynthetic process GO:2000377 regulation of reactive oxygen species metabolic process GO:2000378 negative regulation of reactive oxygen species metabolic process GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway |
Molecular Function | - |
Cellular Component |
GO:0005777 peroxisome GO:0005778 peroxisomal membrane GO:0031903 microbody membrane GO:0042579 microbody GO:0044438 microbody part GO:0044439 peroxisomal part |
KEGG |
hsa04146 Peroxisome |
Reactome | - |
Summary | |
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Symbol | MPV17L |
Name | MPV17 mitochondrial membrane protein-like |
Aliases | FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MPV17L and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MPV17L |
Name | MPV17 mitochondrial membrane protein-like |
Aliases | FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MPV17L in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | MPV17L |
Name | MPV17 mitochondrial membrane protein-like |
Aliases | FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MPV17L in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | MPV17L |
Name | MPV17 mitochondrial membrane protein-like |
Aliases | FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MPV17L. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MPV17L |
Name | MPV17 mitochondrial membrane protein-like |
Aliases | FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MPV17L. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MPV17L. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MPV17L |
Name | MPV17 mitochondrial membrane protein-like |
Aliases | FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MPV17L. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MPV17L |
Name | MPV17 mitochondrial membrane protein-like |
Aliases | FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MPV17L expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MPV17L |
Name | MPV17 mitochondrial membrane protein-like |
Aliases | FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MPV17L and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MPV17L |
Name | MPV17 mitochondrial membrane protein-like |
Aliases | FLJ39599; MLPH1; MLPH2; MPV17L1; M-LPH; MLPH21; M-LP homolog; Mpv17-like protein type 1; Mpv17-like protein ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MPV17L collected from DrugBank database. |
There is no record. |