Summary | |
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Symbol | MR1 |
Name | major histocompatibility complex, class I-related |
Aliases | HLALS; major histocompatibility complex, class I-like sequence; MHC class I-like antigen MR-1; MHC class-I r ...... |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass membrane protein; Extracellular side. Endoplasmic reticulum.; SUBCELLULAR LOCATION: Isoform 4: Secreted.; SUBCELLULAR LOCATION: Isoform 3: Cell membrane Single-pass type I membrane protein Endoplasmic reticulum membrane Note=The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway. |
Domain |
PF07654 Immunoglobulin C1-set domain PF00129 Class I Histocompatibility antigen |
Function |
Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent. |
Biological Process |
GO:0002367 cytokine production involved in immune response GO:0002440 production of molecular mediator of immune response GO:0002474 antigen processing and presentation of peptide antigen via MHC class I GO:0019882 antigen processing and presentation GO:0032611 interleukin-1 beta production GO:0032612 interleukin-1 production GO:0032620 interleukin-17 production GO:0042742 defense response to bacterium GO:0048002 antigen processing and presentation of peptide antigen GO:0050829 defense response to Gram-negative bacterium GO:0098542 defense response to other organism |
Molecular Function |
GO:0003823 antigen binding GO:0032393 MHC class I receptor activity |
Cellular Component |
GO:0042611 MHC protein complex GO:0042612 MHC class I protein complex |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | MR1 |
Name | major histocompatibility complex, class I-related |
Aliases | HLALS; major histocompatibility complex, class I-like sequence; MHC class I-like antigen MR-1; MHC class-I r ...... |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between MR1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | MR1 |
Name | major histocompatibility complex, class I-related |
Aliases | HLALS; major histocompatibility complex, class I-like sequence; MHC class I-like antigen MR-1; MHC class-I r ...... |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MR1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MR1 |
Name | major histocompatibility complex, class I-related |
Aliases | HLALS; major histocompatibility complex, class I-like sequence; MHC class I-like antigen MR-1; MHC class-I r ...... |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of MR1 in various data sets.
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Summary | |
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Symbol | MR1 |
Name | major histocompatibility complex, class I-related |
Aliases | HLALS; major histocompatibility complex, class I-like sequence; MHC class I-like antigen MR-1; MHC class-I r ...... |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MR1 |
Name | major histocompatibility complex, class I-related |
Aliases | HLALS; major histocompatibility complex, class I-like sequence; MHC class I-like antigen MR-1; MHC class-I r ...... |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MR1 |
Name | major histocompatibility complex, class I-related |
Aliases | HLALS; major histocompatibility complex, class I-like sequence; MHC class I-like antigen MR-1; MHC class-I r ...... |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MR1 |
Name | major histocompatibility complex, class I-related |
Aliases | HLALS; major histocompatibility complex, class I-like sequence; MHC class I-like antigen MR-1; MHC class-I r ...... |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MR1 |
Name | major histocompatibility complex, class I-related |
Aliases | HLALS; major histocompatibility complex, class I-like sequence; MHC class I-like antigen MR-1; MHC class-I r ...... |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MR1 |
Name | major histocompatibility complex, class I-related |
Aliases | HLALS; major histocompatibility complex, class I-like sequence; MHC class I-like antigen MR-1; MHC class-I r ...... |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MR1 collected from DrugBank database. |
Details on drugs targeting MR1.
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