Summary | |
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Symbol | MRC2 |
Name | mannose receptor, C type 2 |
Aliases | KIAA0709; ENDO180; CLEC13E; CD280; UPARAP; C-type lectin domain family 13 member E; UPAR-associated protein; ...... |
Chromosomal Location | 17q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF00040 Fibronectin type II domain PF00059 Lectin C-type domain |
Function |
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). |
Biological Process |
GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0030574 collagen catabolic process GO:0032963 collagen metabolic process GO:0044236 multicellular organism metabolic process GO:0044243 multicellular organism catabolic process GO:0044259 multicellular organismal macromolecule metabolic process |
Molecular Function |
GO:0005518 collagen binding GO:0030246 carbohydrate binding |
Cellular Component |
GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction |
KEGG |
hsa04145 Phagosome |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-1236975: Antigen processing-Cross presentation R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-1236978: Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-168256: Immune System |
Summary | |
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Symbol | MRC2 |
Name | mannose receptor, C type 2 |
Aliases | KIAA0709; ENDO180; CLEC13E; CD280; UPARAP; C-type lectin domain family 13 member E; UPAR-associated protein; ...... |
Chromosomal Location | 17q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MRC2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MRC2 |
Name | mannose receptor, C type 2 |
Aliases | KIAA0709; ENDO180; CLEC13E; CD280; UPARAP; C-type lectin domain family 13 member E; UPAR-associated protein; ...... |
Chromosomal Location | 17q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MRC2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MRC2 |
Name | mannose receptor, C type 2 |
Aliases | KIAA0709; ENDO180; CLEC13E; CD280; UPARAP; C-type lectin domain family 13 member E; UPAR-associated protein; ...... |
Chromosomal Location | 17q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MRC2 in various data sets.
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Points in the above scatter plot represent the mutation difference of MRC2 in various data sets.
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Summary | |
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Symbol | MRC2 |
Name | mannose receptor, C type 2 |
Aliases | KIAA0709; ENDO180; CLEC13E; CD280; UPARAP; C-type lectin domain family 13 member E; UPAR-associated protein; ...... |
Chromosomal Location | 17q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MRC2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MRC2 |
Name | mannose receptor, C type 2 |
Aliases | KIAA0709; ENDO180; CLEC13E; CD280; UPARAP; C-type lectin domain family 13 member E; UPAR-associated protein; ...... |
Chromosomal Location | 17q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MRC2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MRC2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MRC2 |
Name | mannose receptor, C type 2 |
Aliases | KIAA0709; ENDO180; CLEC13E; CD280; UPARAP; C-type lectin domain family 13 member E; UPAR-associated protein; ...... |
Chromosomal Location | 17q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MRC2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MRC2 |
Name | mannose receptor, C type 2 |
Aliases | KIAA0709; ENDO180; CLEC13E; CD280; UPARAP; C-type lectin domain family 13 member E; UPAR-associated protein; ...... |
Chromosomal Location | 17q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MRC2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MRC2 |
Name | mannose receptor, C type 2 |
Aliases | KIAA0709; ENDO180; CLEC13E; CD280; UPARAP; C-type lectin domain family 13 member E; UPAR-associated protein; ...... |
Chromosomal Location | 17q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MRC2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MRC2 |
Name | mannose receptor, C type 2 |
Aliases | KIAA0709; ENDO180; CLEC13E; CD280; UPARAP; C-type lectin domain family 13 member E; UPAR-associated protein; ...... |
Chromosomal Location | 17q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MRC2 collected from DrugBank database. |
There is no record. |