Summary | |
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Symbol | MRPS21 |
Name | mitochondrial ribosomal protein S21 |
Aliases | MDS016; MRP-S21; RPMS21; S21mt; mitochondrial 28S ribosomal protein S21; 28S ribosomal protein S21, mitochon ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion |
Domain |
PF01165 Ribosomal protein S21 |
Function |
- |
Biological Process |
GO:0006414 translational elongation GO:0006415 translational termination GO:0032543 mitochondrial translation GO:0032984 macromolecular complex disassembly GO:0043241 protein complex disassembly GO:0043624 cellular protein complex disassembly GO:0070125 mitochondrial translational elongation GO:0070126 mitochondrial translational termination |
Molecular Function |
GO:0003735 structural constituent of ribosome |
Cellular Component |
GO:0000313 organellar ribosome GO:0000314 organellar small ribosomal subunit GO:0005743 mitochondrial inner membrane GO:0005759 mitochondrial matrix GO:0005761 mitochondrial ribosome GO:0005763 mitochondrial small ribosomal subunit GO:0005840 ribosome GO:0015935 small ribosomal subunit GO:0044391 ribosomal subunit |
KEGG |
hsa03010 Ribosome |
Reactome |
R-HSA-5368287: Mitochondrial translation R-HSA-5389840: Mitochondrial translation elongation R-HSA-5368286: Mitochondrial translation initiation R-HSA-5419276: Mitochondrial translation termination R-HSA-1852241: Organelle biogenesis and maintenance |
Summary | |
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Symbol | MRPS21 |
Name | mitochondrial ribosomal protein S21 |
Aliases | MDS016; MRP-S21; RPMS21; S21mt; mitochondrial 28S ribosomal protein S21; 28S ribosomal protein S21, mitochon ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MRPS21 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MRPS21 |
Name | mitochondrial ribosomal protein S21 |
Aliases | MDS016; MRP-S21; RPMS21; S21mt; mitochondrial 28S ribosomal protein S21; 28S ribosomal protein S21, mitochon ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MRPS21 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MRPS21 |
Name | mitochondrial ribosomal protein S21 |
Aliases | MDS016; MRP-S21; RPMS21; S21mt; mitochondrial 28S ribosomal protein S21; 28S ribosomal protein S21, mitochon ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MRPS21 in various data sets.
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Points in the above scatter plot represent the mutation difference of MRPS21 in various data sets.
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Summary | |
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Symbol | MRPS21 |
Name | mitochondrial ribosomal protein S21 |
Aliases | MDS016; MRP-S21; RPMS21; S21mt; mitochondrial 28S ribosomal protein S21; 28S ribosomal protein S21, mitochon ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MRPS21. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MRPS21 |
Name | mitochondrial ribosomal protein S21 |
Aliases | MDS016; MRP-S21; RPMS21; S21mt; mitochondrial 28S ribosomal protein S21; 28S ribosomal protein S21, mitochon ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MRPS21. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MRPS21. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MRPS21 |
Name | mitochondrial ribosomal protein S21 |
Aliases | MDS016; MRP-S21; RPMS21; S21mt; mitochondrial 28S ribosomal protein S21; 28S ribosomal protein S21, mitochon ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MRPS21. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MRPS21 |
Name | mitochondrial ribosomal protein S21 |
Aliases | MDS016; MRP-S21; RPMS21; S21mt; mitochondrial 28S ribosomal protein S21; 28S ribosomal protein S21, mitochon ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MRPS21 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MRPS21 |
Name | mitochondrial ribosomal protein S21 |
Aliases | MDS016; MRP-S21; RPMS21; S21mt; mitochondrial 28S ribosomal protein S21; 28S ribosomal protein S21, mitochon ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MRPS21 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MRPS21 |
Name | mitochondrial ribosomal protein S21 |
Aliases | MDS016; MRP-S21; RPMS21; S21mt; mitochondrial 28S ribosomal protein S21; 28S ribosomal protein S21, mitochon ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MRPS21 collected from DrugBank database. |
There is no record. |