Browse MRVI1

Summary
SymbolMRVI1
Namemurine retrovirus integration site 1 homolog
Aliases JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, perinuclear region. Sarcoplasmic reticulum Membrane Single-pass membrane protein
Domain PF05781 MRVI1 protein
Function

Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation.

> Gene Ontology
 
Biological Process -
Molecular Function -
Cellular Component GO:0016528 sarcoplasm
GO:0016529 sarcoplasmic reticulum
GO:0031094 platelet dense tubular network
GO:0031095 platelet dense tubular network membrane
> KEGG and Reactome Pathway
 
KEGG hsa04022 cGMP-PKG signaling pathway
hsa04270 Vascular smooth muscle contraction
Reactome R-HSA-109582: Hemostasis
R-HSA-392154: Nitric oxide stimulates guanylate cyclase
R-HSA-418346: Platelet homeostasis
R-HSA-418457: cGMP effects
Summary
SymbolMRVI1
Namemurine retrovirus integration site 1 homolog
Aliases JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MRVI1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolMRVI1
Namemurine retrovirus integration site 1 homolog
Aliases JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MRVI1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolMRVI1
Namemurine retrovirus integration site 1 homolog
Aliases JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MRVI1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6420.0203
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.8220.136
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.5120.27
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1810.731
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4160.858
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1180.969
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1690.661
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1420.881
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1690.875
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6690.49
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.3440.302
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4140.00963
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MRVI1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.45.51.90.66
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMRVI1
Namemurine retrovirus integration site 1 homolog
Aliases JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MRVI1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMRVI1
Namemurine retrovirus integration site 1 homolog
Aliases JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MRVI1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MRVI1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMRVI1
Namemurine retrovirus integration site 1 homolog
Aliases JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MRVI1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMRVI1
Namemurine retrovirus integration site 1 homolog
Aliases JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MRVI1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMRVI1
Namemurine retrovirus integration site 1 homolog
Aliases JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MRVI1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMRVI1
Namemurine retrovirus integration site 1 homolog
Aliases JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ......
Chromosomal Location11p15.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MRVI1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.