Summary | |
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Symbol | MRVI1 |
Name | murine retrovirus integration site 1 homolog |
Aliases | JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, perinuclear region. Sarcoplasmic reticulum Membrane Single-pass membrane protein |
Domain |
PF05781 MRVI1 protein |
Function |
Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. |
Biological Process | - |
Molecular Function | - |
Cellular Component |
GO:0016528 sarcoplasm GO:0016529 sarcoplasmic reticulum GO:0031094 platelet dense tubular network GO:0031095 platelet dense tubular network membrane |
KEGG |
hsa04022 cGMP-PKG signaling pathway hsa04270 Vascular smooth muscle contraction |
Reactome |
R-HSA-109582: Hemostasis R-HSA-392154: Nitric oxide stimulates guanylate cyclase R-HSA-418346: Platelet homeostasis R-HSA-418457: cGMP effects |
Summary | |
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Symbol | MRVI1 |
Name | murine retrovirus integration site 1 homolog |
Aliases | JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MRVI1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MRVI1 |
Name | murine retrovirus integration site 1 homolog |
Aliases | JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MRVI1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | MRVI1 |
Name | murine retrovirus integration site 1 homolog |
Aliases | JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MRVI1 in various data sets.
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Points in the above scatter plot represent the mutation difference of MRVI1 in various data sets.
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Summary | |
---|---|
Symbol | MRVI1 |
Name | murine retrovirus integration site 1 homolog |
Aliases | JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MRVI1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MRVI1 |
Name | murine retrovirus integration site 1 homolog |
Aliases | JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MRVI1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MRVI1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MRVI1 |
Name | murine retrovirus integration site 1 homolog |
Aliases | JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MRVI1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MRVI1 |
Name | murine retrovirus integration site 1 homolog |
Aliases | JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MRVI1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MRVI1 |
Name | murine retrovirus integration site 1 homolog |
Aliases | JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MRVI1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MRVI1 |
Name | murine retrovirus integration site 1 homolog |
Aliases | JAW1L; IRAG; inositol 1,4,5-triphosphate-associated cGMP kinase substrate; IP3R-associated cGMP kinase subst ...... |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MRVI1 collected from DrugBank database. |
There is no record. |