Summary | |
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Symbol | MSR1 |
Name | macrophage scavenger receptor 1 |
Aliases | SCARA1; CD204; SR-A; phSR1; phSR2; macrophage acetylated LDL receptor I and II; macrophage scavenger recepto ...... |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type II membrane protein. |
Domain |
PF01391 Collagen triple helix repeat (20 copies) PF03523 Macrophage scavenger receptor PF00530 Scavenger receptor cysteine-rich domain |
Function |
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254). Isoform III does not internalize acetylated LDL (PubMed:9548586). |
Biological Process |
GO:0006869 lipid transport GO:0006898 receptor-mediated endocytosis GO:0010742 macrophage derived foam cell differentiation GO:0010743 regulation of macrophage derived foam cell differentiation GO:0010744 positive regulation of macrophage derived foam cell differentiation GO:0010876 lipid localization GO:0010878 cholesterol storage GO:0010883 regulation of lipid storage GO:0010884 positive regulation of lipid storage GO:0010885 regulation of cholesterol storage GO:0010886 positive regulation of cholesterol storage GO:0015850 organic hydroxy compound transport GO:0015918 sterol transport GO:0019915 lipid storage GO:0030301 cholesterol transport GO:0034381 plasma lipoprotein particle clearance GO:0042953 lipoprotein transport GO:0044872 lipoprotein localization GO:0051235 maintenance of location GO:0071407 cellular response to organic cyclic compound GO:0090077 foam cell differentiation GO:0097006 regulation of plasma lipoprotein particle levels |
Molecular Function |
GO:0005044 scavenger receptor activity GO:0030169 low-density lipoprotein particle binding GO:0038024 cargo receptor activity GO:0071813 lipoprotein particle binding GO:0071814 protein-lipid complex binding |
Cellular Component |
GO:0005581 collagen trimer GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030666 endocytic vesicle membrane GO:0032994 protein-lipid complex GO:0034358 plasma lipoprotein particle GO:0034362 low-density lipoprotein particle GO:1990777 lipoprotein particle |
KEGG |
hsa04145 Phagosome |
Reactome |
R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors R-HSA-3000480: Scavenging by Class A Receptors R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | MSR1 |
Name | macrophage scavenger receptor 1 |
Aliases | SCARA1; CD204; SR-A; phSR1; phSR2; macrophage acetylated LDL receptor I and II; macrophage scavenger recepto ...... |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MSR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between MSR1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | MSR1 |
Name | macrophage scavenger receptor 1 |
Aliases | SCARA1; CD204; SR-A; phSR1; phSR2; macrophage acetylated LDL receptor I and II; macrophage scavenger recepto ...... |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MSR1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MSR1 |
Name | macrophage scavenger receptor 1 |
Aliases | SCARA1; CD204; SR-A; phSR1; phSR2; macrophage acetylated LDL receptor I and II; macrophage scavenger recepto ...... |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MSR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of MSR1 in various data sets.
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Summary | |
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Symbol | MSR1 |
Name | macrophage scavenger receptor 1 |
Aliases | SCARA1; CD204; SR-A; phSR1; phSR2; macrophage acetylated LDL receptor I and II; macrophage scavenger recepto ...... |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MSR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MSR1 |
Name | macrophage scavenger receptor 1 |
Aliases | SCARA1; CD204; SR-A; phSR1; phSR2; macrophage acetylated LDL receptor I and II; macrophage scavenger recepto ...... |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MSR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MSR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MSR1 |
Name | macrophage scavenger receptor 1 |
Aliases | SCARA1; CD204; SR-A; phSR1; phSR2; macrophage acetylated LDL receptor I and II; macrophage scavenger recepto ...... |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MSR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MSR1 |
Name | macrophage scavenger receptor 1 |
Aliases | SCARA1; CD204; SR-A; phSR1; phSR2; macrophage acetylated LDL receptor I and II; macrophage scavenger recepto ...... |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MSR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MSR1 |
Name | macrophage scavenger receptor 1 |
Aliases | SCARA1; CD204; SR-A; phSR1; phSR2; macrophage acetylated LDL receptor I and II; macrophage scavenger recepto ...... |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MSR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MSR1 |
Name | macrophage scavenger receptor 1 |
Aliases | SCARA1; CD204; SR-A; phSR1; phSR2; macrophage acetylated LDL receptor I and II; macrophage scavenger recepto ...... |
Chromosomal Location | 8p22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MSR1 collected from DrugBank database. |
There is no record. |