Summary | |
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Symbol | MSRB1 |
Name | methionine sulfoxide reductase B1 |
Aliases | SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Cytoplasm, cytoskeleton |
Domain |
PF01641 SelR domain |
Function |
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages. |
Biological Process |
GO:0006979 response to oxidative stress GO:0007015 actin filament organization GO:0008154 actin polymerization or depolymerization GO:0030041 actin filament polymerization GO:0030091 protein repair GO:0051258 protein polymerization |
Molecular Function |
GO:0003779 actin binding GO:0016667 oxidoreductase activity, acting on a sulfur group of donors GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0033743 peptide-methionine (R)-S-oxide reductase activity GO:0070191 methionine-R-sulfoxide reductase activity |
Cellular Component |
GO:0015629 actin cytoskeleton |
KEGG | - |
Reactome |
R-HSA-392499: Metabolism of proteins R-HSA-5676934: Protein repair |
Summary | |
---|---|
Symbol | MSRB1 |
Name | methionine sulfoxide reductase B1 |
Aliases | SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MSRB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MSRB1 |
Name | methionine sulfoxide reductase B1 |
Aliases | SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MSRB1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MSRB1 |
Name | methionine sulfoxide reductase B1 |
Aliases | SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MSRB1 in various data sets.
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Points in the above scatter plot represent the mutation difference of MSRB1 in various data sets.
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Summary | |
---|---|
Symbol | MSRB1 |
Name | methionine sulfoxide reductase B1 |
Aliases | SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MSRB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MSRB1 |
Name | methionine sulfoxide reductase B1 |
Aliases | SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MSRB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MSRB1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MSRB1 |
Name | methionine sulfoxide reductase B1 |
Aliases | SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MSRB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MSRB1 |
Name | methionine sulfoxide reductase B1 |
Aliases | SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MSRB1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MSRB1 |
Name | methionine sulfoxide reductase B1 |
Aliases | SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MSRB1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MSRB1 |
Name | methionine sulfoxide reductase B1 |
Aliases | SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ...... |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MSRB1 collected from DrugBank database. |
There is no record. |