Browse MSRB1

Summary
SymbolMSRB1
Namemethionine sulfoxide reductase B1
Aliases SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Cytoplasm, cytoskeleton
Domain PF01641 SelR domain
Function

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.

> Gene Ontology
 
Biological Process GO:0006979 response to oxidative stress
GO:0007015 actin filament organization
GO:0008154 actin polymerization or depolymerization
GO:0030041 actin filament polymerization
GO:0030091 protein repair
GO:0051258 protein polymerization
Molecular Function GO:0003779 actin binding
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
GO:0033743 peptide-methionine (R)-S-oxide reductase activity
GO:0070191 methionine-R-sulfoxide reductase activity
Cellular Component GO:0015629 actin cytoskeleton
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-392499: Metabolism of proteins
R-HSA-5676934: Protein repair
Summary
SymbolMSRB1
Namemethionine sulfoxide reductase B1
Aliases SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MSRB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolMSRB1
Namemethionine sulfoxide reductase B1
Aliases SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MSRB1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 4.55; FDR: 0.011 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolMSRB1
Namemethionine sulfoxide reductase B1
Aliases SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MSRB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2020.418
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2480.909
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.5340.728
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3060.499
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0240.981
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.730.591
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0390.904
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0120.992
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1520.91
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1070.957
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.3910.896
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0550.562
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MSRB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMSRB1
Namemethionine sulfoxide reductase B1
Aliases SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MSRB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMSRB1
Namemethionine sulfoxide reductase B1
Aliases SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MSRB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MSRB1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMSRB1
Namemethionine sulfoxide reductase B1
Aliases SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MSRB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMSRB1
Namemethionine sulfoxide reductase B1
Aliases SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MSRB1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMSRB1
Namemethionine sulfoxide reductase B1
Aliases SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MSRB1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMSRB1
Namemethionine sulfoxide reductase B1
Aliases SelR; SepR; SelX; SEPX1; selenoprotein X, 1; HSPC270; selenoprotein R; Selenoprotein X; Methionine-R-sulfoxi ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MSRB1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.