Browse MSX1

Summary
SymbolMSX1
Namemsh homeobox 1
Aliases HYD1; OFC5; HOX7; msh (Drosophila) homeo box homolog 1 (formerly homeo box 7); msh homeobox homolog 1 (Droso ......
Chromosomal Location4p16.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF00046 Homeobox domain
Function

Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001558 regulation of cell growth
GO:0001701 in utero embryonic development
GO:0001837 epithelial to mesenchymal transition
GO:0003002 regionalization
GO:0003007 heart morphogenesis
GO:0003197 endocardial cushion development
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203 endocardial cushion morphogenesis
GO:0003272 endocardial cushion formation
GO:0007126 meiotic nuclear division
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007389 pattern specification process
GO:0007423 sensory organ development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0009952 anterior/posterior pattern specification
GO:0010171 body morphogenesis
GO:0010463 mesenchymal cell proliferation
GO:0016049 cell growth
GO:0021536 diencephalon development
GO:0021983 pituitary gland development
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030308 negative regulation of cell growth
GO:0030326 embryonic limb morphogenesis
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0030509 BMP signaling pathway
GO:0030510 regulation of BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030879 mammary gland development
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0031647 regulation of protein stability
GO:0034504 protein localization to nucleus
GO:0035094 response to nicotine
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035136 forelimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0035270 endocrine system development
GO:0035878 nail development
GO:0035880 embryonic nail plate morphogenesis
GO:0040020 regulation of meiotic nuclear division
GO:0042471 ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042481 regulation of odontogenesis
GO:0042692 muscle cell differentiation
GO:0042733 embryonic digit morphogenesis
GO:0042770 signal transduction in response to DNA damage
GO:0043279 response to alkaloid
GO:0043392 negative regulation of DNA binding
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043583 ear development
GO:0045787 positive regulation of cell cycle
GO:0045836 positive regulation of meiotic nuclear division
GO:0045926 negative regulation of growth
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048705 skeletal system morphogenesis
GO:0048732 gland development
GO:0048736 appendage development
GO:0048762 mesenchymal cell differentiation
GO:0048863 stem cell differentiation
GO:0050821 protein stabilization
GO:0051098 regulation of binding
GO:0051100 negative regulation of binding
GO:0051101 regulation of DNA binding
GO:0051146 striated muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051148 negative regulation of muscle cell differentiation
GO:0051153 regulation of striated muscle cell differentiation
GO:0051154 negative regulation of striated muscle cell differentiation
GO:0051216 cartilage development
GO:0051321 meiotic cell cycle
GO:0051445 regulation of meiotic cell cycle
GO:0051446 positive regulation of meiotic cell cycle
GO:0051783 regulation of nuclear division
GO:0051785 positive regulation of nuclear division
GO:0060021 palate development
GO:0060173 limb development
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060323 head morphogenesis
GO:0060324 face development
GO:0060325 face morphogenesis
GO:0060348 bone development
GO:0060349 bone morphogenesis
GO:0060485 mesenchyme development
GO:0060536 cartilage morphogenesis
GO:0061180 mammary gland epithelium development
GO:0061311 cell surface receptor signaling pathway involved in heart development
GO:0061312 BMP signaling pathway involved in heart development
GO:0061448 connective tissue development
GO:0071312 cellular response to alkaloid
GO:0071316 cellular response to nicotine
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071772 response to BMP
GO:0071773 cellular response to BMP stimulus
GO:0072132 mesenchyme morphogenesis
GO:0072331 signal transduction by p53 class mediator
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090068 positive regulation of cell cycle process
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090427 activation of meiosis
GO:0090596 sensory organ morphogenesis
GO:0097152 mesenchymal cell apoptotic process
GO:0097193 intrinsic apoptotic signaling pathway
GO:1901213 regulation of transcription from RNA polymerase II promoter involved in heart development
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901798 positive regulation of signal transduction by p53 class mediator
GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1903046 meiotic cell cycle process
GO:2000027 regulation of organ morphogenesis
GO:2000241 regulation of reproductive process
GO:2000243 positive regulation of reproductive process
GO:2000677 regulation of transcription regulatory region DNA binding
GO:2000678 negative regulation of transcription regulatory region DNA binding
GO:2001020 regulation of response to DNA damage stimulus
GO:2001022 positive regulation of response to DNA damage stimulus
GO:2001053 regulation of mesenchymal cell apoptotic process
GO:2001055 positive regulation of mesenchymal cell apoptotic process
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0002039 p53 binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolMSX1
Namemsh homeobox 1
Aliases HYD1; OFC5; HOX7; msh (Drosophila) homeo box homolog 1 (formerly homeo box 7); msh homeobox homolog 1 (Droso ......
Chromosomal Location4p16.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MSX1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolMSX1
Namemsh homeobox 1
Aliases HYD1; OFC5; HOX7; msh (Drosophila) homeo box homolog 1 (formerly homeo box 7); msh homeobox homolog 1 (Droso ......
Chromosomal Location4p16.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MSX1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolMSX1
Namemsh homeobox 1
Aliases HYD1; OFC5; HOX7; msh (Drosophila) homeo box homolog 1 (formerly homeo box 7); msh homeobox homolog 1 (Droso ......
Chromosomal Location4p16.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MSX1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.2940.027
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-2.0870.116
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.7190.52
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1940.844
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.1210.612
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.9830.704
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.6710.179
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.8920.296
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3010.718
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7790.345
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.6560.113
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1490.428
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MSX1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMSX1
Namemsh homeobox 1
Aliases HYD1; OFC5; HOX7; msh (Drosophila) homeo box homolog 1 (formerly homeo box 7); msh homeobox homolog 1 (Droso ......
Chromosomal Location4p16.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MSX1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMSX1
Namemsh homeobox 1
Aliases HYD1; OFC5; HOX7; msh (Drosophila) homeo box homolog 1 (formerly homeo box 7); msh homeobox homolog 1 (Droso ......
Chromosomal Location4p16.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MSX1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MSX1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMSX1
Namemsh homeobox 1
Aliases HYD1; OFC5; HOX7; msh (Drosophila) homeo box homolog 1 (formerly homeo box 7); msh homeobox homolog 1 (Droso ......
Chromosomal Location4p16.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MSX1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMSX1
Namemsh homeobox 1
Aliases HYD1; OFC5; HOX7; msh (Drosophila) homeo box homolog 1 (formerly homeo box 7); msh homeobox homolog 1 (Droso ......
Chromosomal Location4p16.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MSX1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMSX1
Namemsh homeobox 1
Aliases HYD1; OFC5; HOX7; msh (Drosophila) homeo box homolog 1 (formerly homeo box 7); msh homeobox homolog 1 (Droso ......
Chromosomal Location4p16.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MSX1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMSX1
Namemsh homeobox 1
Aliases HYD1; OFC5; HOX7; msh (Drosophila) homeo box homolog 1 (formerly homeo box 7); msh homeobox homolog 1 (Droso ......
Chromosomal Location4p16.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MSX1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.