Summary | |
---|---|
Symbol | MT1X |
Name | metallothionein 1X |
Aliases | MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X |
Chromosomal Location | 16q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00131 Metallothionein |
Function |
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling (PubMed:23251525). |
Biological Process |
GO:0006875 cellular metal ion homeostasis GO:0006882 cellular zinc ion homeostasis GO:0007263 nitric oxide mediated signal transduction GO:0009636 response to toxic substance GO:0010001 glial cell differentiation GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010043 response to zinc ion GO:0010273 detoxification of copper ion GO:0014002 astrocyte development GO:0019932 second-messenger-mediated signaling GO:0021782 glial cell development GO:0036017 response to erythropoietin GO:0036018 cellular response to erythropoietin GO:0042063 gliogenesis GO:0045926 negative regulation of growth GO:0046686 response to cadmium ion GO:0046688 response to copper ion GO:0046916 cellular transition metal ion homeostasis GO:0048143 astrocyte activation GO:0048708 astrocyte differentiation GO:0055069 zinc ion homeostasis GO:0055076 transition metal ion homeostasis GO:0061687 detoxification of inorganic compound GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071276 cellular response to cadmium ion GO:0071294 cellular response to zinc ion GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0097501 stress response to metal ion GO:0098754 detoxification GO:1990169 stress response to copper ion GO:1990267 response to transition metal nanoparticle |
Molecular Function |
GO:0046870 cadmium ion binding |
Cellular Component | - |
KEGG |
hsa04978 Mineral absorption |
Reactome |
R-HSA-1430728: Metabolism R-HSA-5661231: Metallothioneins bind metals R-HSA-5660526: Response to metal ions |
Summary | |
---|---|
Symbol | MT1X |
Name | metallothionein 1X |
Aliases | MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X |
Chromosomal Location | 16q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MT1X and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MT1X |
Name | metallothionein 1X |
Aliases | MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X |
Chromosomal Location | 16q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MT1X in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | MT1X |
Name | metallothionein 1X |
Aliases | MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X |
Chromosomal Location | 16q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MT1X in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | MT1X |
Name | metallothionein 1X |
Aliases | MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X |
Chromosomal Location | 16q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MT1X. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MT1X |
Name | metallothionein 1X |
Aliases | MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X |
Chromosomal Location | 16q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MT1X. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MT1X. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MT1X |
Name | metallothionein 1X |
Aliases | MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X |
Chromosomal Location | 16q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MT1X. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MT1X |
Name | metallothionein 1X |
Aliases | MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X |
Chromosomal Location | 16q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MT1X expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MT1X |
Name | metallothionein 1X |
Aliases | MT-1X; MT-IX; metallothionein-IX; Metallothionein-1X |
Chromosomal Location | 16q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MT1X and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |