Summary | |
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Symbol | MUC5AC |
Name | mucin 5AC, oligomeric mucus/gel-forming |
Aliases | mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF08742 C8 domain PF13330 Mucin-2 protein WxxW repeating region PF01826 Trypsin Inhibitor like cysteine rich domain PF00094 von Willebrand factor type D domain |
Function |
Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system. |
Biological Process |
GO:0001894 tissue homeostasis GO:0006486 protein glycosylation GO:0006493 protein O-linked glycosylation GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0016266 O-glycan processing GO:0030198 extracellular matrix organization GO:0036438 maintenance of lens transparency GO:0043062 extracellular structure organization GO:0043206 extracellular fibril organization GO:0043413 macromolecule glycosylation GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048871 multicellular organismal homeostasis GO:0060249 anatomical structure homeostasis GO:0070085 glycosylation GO:0097435 fibril organization |
Molecular Function |
GO:0005201 extracellular matrix structural constituent |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005796 Golgi lumen GO:0043205 fibril GO:0044420 extracellular matrix component |
KEGG | - |
Reactome |
R-HSA-5621481: C-type lectin receptors (CLRs) R-HSA-5621480: Dectin-2 family R-HSA-5083632: Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) R-HSA-5083636: Defective GALNT12 causes colorectal cancer 1 (CRCS1) R-HSA-5083625: Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) R-HSA-1643685: Disease R-HSA-3906995: Diseases associated with O-glycosylation of proteins R-HSA-3781865: Diseases of glycosylation R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-392499: Metabolism of proteins R-HSA-5173105: O-linked glycosylation R-HSA-913709: O-linked glycosylation of mucins R-HSA-597592: Post-translational protein modification R-HSA-977068: Termination of O-glycan biosynthesis |
Summary | |
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Symbol | MUC5AC |
Name | mucin 5AC, oligomeric mucus/gel-forming |
Aliases | mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MUC5AC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between MUC5AC and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | MUC5AC |
Name | mucin 5AC, oligomeric mucus/gel-forming |
Aliases | mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MUC5AC in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MUC5AC |
Name | mucin 5AC, oligomeric mucus/gel-forming |
Aliases | mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MUC5AC in various data sets.
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Points in the above scatter plot represent the mutation difference of MUC5AC in various data sets.
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Summary | |
---|---|
Symbol | MUC5AC |
Name | mucin 5AC, oligomeric mucus/gel-forming |
Aliases | mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MUC5AC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MUC5AC |
Name | mucin 5AC, oligomeric mucus/gel-forming |
Aliases | mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MUC5AC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MUC5AC. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MUC5AC |
Name | mucin 5AC, oligomeric mucus/gel-forming |
Aliases | mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MUC5AC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MUC5AC |
Name | mucin 5AC, oligomeric mucus/gel-forming |
Aliases | mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MUC5AC expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MUC5AC |
Name | mucin 5AC, oligomeric mucus/gel-forming |
Aliases | mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MUC5AC and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MUC5AC |
Name | mucin 5AC, oligomeric mucus/gel-forming |
Aliases | mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ...... |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MUC5AC collected from DrugBank database. |
There is no record. |