Browse MUC5AC

Summary
SymbolMUC5AC
Namemucin 5AC, oligomeric mucus/gel-forming
Aliases mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted
Domain PF08742 C8 domain
PF13330 Mucin-2 protein WxxW repeating region
PF01826 Trypsin Inhibitor like cysteine rich domain
PF00094 von Willebrand factor type D domain
Function

Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.

> Gene Ontology
 
Biological Process GO:0001894 tissue homeostasis
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0009100 glycoprotein metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0016266 O-glycan processing
GO:0030198 extracellular matrix organization
GO:0036438 maintenance of lens transparency
GO:0043062 extracellular structure organization
GO:0043206 extracellular fibril organization
GO:0043413 macromolecule glycosylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048871 multicellular organismal homeostasis
GO:0060249 anatomical structure homeostasis
GO:0070085 glycosylation
GO:0097435 fibril organization
Molecular Function GO:0005201 extracellular matrix structural constituent
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005796 Golgi lumen
GO:0043205 fibril
GO:0044420 extracellular matrix component
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-5621481: C-type lectin receptors (CLRs)
R-HSA-5621480: Dectin-2 family
R-HSA-5083632: Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636: Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5083625: Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-1643685: Disease
R-HSA-3906995: Diseases associated with O-glycosylation of proteins
R-HSA-3781865: Diseases of glycosylation
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-392499: Metabolism of proteins
R-HSA-5173105: O-linked glycosylation
R-HSA-913709: O-linked glycosylation of mucins
R-HSA-597592: Post-translational protein modification
R-HSA-977068: Termination of O-glycan biosynthesis
Summary
SymbolMUC5AC
Namemucin 5AC, oligomeric mucus/gel-forming
Aliases mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MUC5AC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between MUC5AC and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
16778191Breast CarcinomaInhibit immunity (T cell function)Different progression of tumor xenografts between mucin-producing and mucin-non-producing mammary adenocarcinoma-bearing mice. tumor formation by using mucin-producing (TA3-Ha) and mucin-non-producing (TA3-St) cloned variants of mouse mammary adenocarcinomas. IFN-gamma-producing CD4 T cells in spleens obtained from TA3-Ha tumor-bearing mice were significantly reduced compared with TA3-St tumor-bearing mice, suggesting that mucins cause PGE2-mediated immune suppression.
29625896hepatocellular carcinomaInhibit immunity (infiltration)Putative B7S1 receptor was co-expressed with PD-1 but not T cell immunoglobulin and mucin-domain containing-3 (Tim-3) at an activated state of early tumor-infiltrating CD8+ T cells, and B7S1 promoted T cell exhaustion, possibly through Eomes overexpression.
Summary
SymbolMUC5AC
Namemucin 5AC, oligomeric mucus/gel-forming
Aliases mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MUC5AC in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolMUC5AC
Namemucin 5AC, oligomeric mucus/gel-forming
Aliases mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MUC5AC in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5930.409
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.7260.174
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8310.556
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0580.889
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0580.927
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.9360.0795
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MUC5AC in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.614.8-12.20.151
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.523.1-18.60.134
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMUC5AC
Namemucin 5AC, oligomeric mucus/gel-forming
Aliases mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MUC5AC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMUC5AC
Namemucin 5AC, oligomeric mucus/gel-forming
Aliases mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MUC5AC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MUC5AC.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMUC5AC
Namemucin 5AC, oligomeric mucus/gel-forming
Aliases mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MUC5AC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMUC5AC
Namemucin 5AC, oligomeric mucus/gel-forming
Aliases mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MUC5AC expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMUC5AC
Namemucin 5AC, oligomeric mucus/gel-forming
Aliases mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MUC5AC and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMUC5AC
Namemucin 5AC, oligomeric mucus/gel-forming
Aliases mucin 5, subtypes A and C, tracheobronchial/gastric; TBM; leB; mucin; gastric mucin; lewis B blood group ant ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MUC5AC collected from DrugBank database.
> Drugs from DrugBank database
 

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