Summary | |
---|---|
Symbol | MUSK |
Name | muscle, skeletal, receptor tyrosine kinase |
Aliases | CMS9; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; Muscle, skeletal re ...... |
Chromosomal Location | 9q31.3-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane Single-pass type I membrane protein Note=Colocalizes with acetylcholine receptors (AChR) to the postsynaptic cell membrane of the neuromuscular junction. |
Domain |
PF01392 Fz domain PF07679 Immunoglobulin I-set domain PF07714 Protein tyrosine kinase |
Function |
Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity). |
Biological Process |
GO:0001941 postsynaptic membrane organization GO:0007416 synapse assembly GO:0007528 neuromuscular junction development GO:0007611 learning or memory GO:0007613 memory GO:0008582 regulation of synaptic growth at neuromuscular junction GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0018342 protein prenylation GO:0018344 protein geranylgeranylation GO:0043113 receptor clustering GO:0044708 single-organism behavior GO:0046777 protein autophosphorylation GO:0048638 regulation of developmental growth GO:0050803 regulation of synapse structure or activity GO:0050807 regulation of synapse organization GO:0050808 synapse organization GO:0050890 cognition GO:0051124 synaptic growth at neuromuscular junction GO:0051668 localization within membrane GO:0051963 regulation of synapse assembly GO:0071340 skeletal muscle acetylcholine-gated channel clustering GO:0072657 protein localization to membrane GO:0097354 prenylation GO:1904396 regulation of neuromuscular junction development GO:2000539 regulation of protein geranylgeranylation GO:2000541 positive regulation of protein geranylgeranylation |
Molecular Function |
GO:0004713 protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0019199 transmembrane receptor protein kinase activity |
Cellular Component |
GO:0031594 neuromuscular junction GO:0043235 receptor complex GO:0045211 postsynaptic membrane GO:0097060 synaptic membrane GO:0098794 postsynapse |
KEGG | - |
Reactome |
R-HSA-3000178: ECM proteoglycans R-HSA-1474244: Extracellular matrix organization |
Summary | |
---|---|
Symbol | MUSK |
Name | muscle, skeletal, receptor tyrosine kinase |
Aliases | CMS9; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; Muscle, skeletal re ...... |
Chromosomal Location | 9q31.3-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MUSK and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MUSK |
Name | muscle, skeletal, receptor tyrosine kinase |
Aliases | CMS9; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; Muscle, skeletal re ...... |
Chromosomal Location | 9q31.3-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of MUSK in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | MUSK |
Name | muscle, skeletal, receptor tyrosine kinase |
Aliases | CMS9; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; Muscle, skeletal re ...... |
Chromosomal Location | 9q31.3-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MUSK in various data sets.
|
Points in the above scatter plot represent the mutation difference of MUSK in various data sets.
|
Summary | |
---|---|
Symbol | MUSK |
Name | muscle, skeletal, receptor tyrosine kinase |
Aliases | CMS9; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; Muscle, skeletal re ...... |
Chromosomal Location | 9q31.3-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MUSK. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MUSK |
Name | muscle, skeletal, receptor tyrosine kinase |
Aliases | CMS9; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; Muscle, skeletal re ...... |
Chromosomal Location | 9q31.3-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MUSK. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MUSK. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MUSK |
Name | muscle, skeletal, receptor tyrosine kinase |
Aliases | CMS9; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; Muscle, skeletal re ...... |
Chromosomal Location | 9q31.3-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MUSK. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MUSK |
Name | muscle, skeletal, receptor tyrosine kinase |
Aliases | CMS9; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; Muscle, skeletal re ...... |
Chromosomal Location | 9q31.3-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MUSK expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MUSK |
Name | muscle, skeletal, receptor tyrosine kinase |
Aliases | CMS9; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; Muscle, skeletal re ...... |
Chromosomal Location | 9q31.3-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MUSK and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MUSK |
Name | muscle, skeletal, receptor tyrosine kinase |
Aliases | CMS9; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; Muscle, skeletal re ...... |
Chromosomal Location | 9q31.3-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MUSK collected from DrugBank database. |
There is no record. |