Summary | |
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Symbol | MYCL |
Name | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog |
Aliases | LMYC; l-myc protein; myc-related gene from lung cancer; oncogene lmyc; MYCL1; v-myc avian myelocytomatosis v ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00010 Helix-loop-helix DNA-binding domain PF01056 Myc amino-terminal region |
Function |
- |
Biological Process |
GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0007423 sensory organ development GO:0008544 epidermis development GO:0009913 epidermal cell differentiation GO:0030856 regulation of epithelial cell differentiation GO:0035315 hair cell differentiation GO:0042490 mechanoreceptor differentiation GO:0042491 auditory receptor cell differentiation GO:0043583 ear development GO:0045604 regulation of epidermal cell differentiation GO:0045607 regulation of auditory receptor cell differentiation GO:0045631 regulation of mechanoreceptor differentiation GO:0045682 regulation of epidermis development GO:0048839 inner ear development GO:0060113 inner ear receptor cell differentiation GO:0060563 neuroepithelial cell differentiation GO:2000980 regulation of inner ear receptor cell differentiation |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | MYCL |
Name | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog |
Aliases | LMYC; l-myc protein; myc-related gene from lung cancer; oncogene lmyc; MYCL1; v-myc avian myelocytomatosis v ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MYCL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MYCL |
Name | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog |
Aliases | LMYC; l-myc protein; myc-related gene from lung cancer; oncogene lmyc; MYCL1; v-myc avian myelocytomatosis v ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MYCL in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MYCL |
Name | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog |
Aliases | LMYC; l-myc protein; myc-related gene from lung cancer; oncogene lmyc; MYCL1; v-myc avian myelocytomatosis v ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MYCL in various data sets.
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Points in the above scatter plot represent the mutation difference of MYCL in various data sets.
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Summary | |
---|---|
Symbol | MYCL |
Name | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog |
Aliases | LMYC; l-myc protein; myc-related gene from lung cancer; oncogene lmyc; MYCL1; v-myc avian myelocytomatosis v ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MYCL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MYCL |
Name | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog |
Aliases | LMYC; l-myc protein; myc-related gene from lung cancer; oncogene lmyc; MYCL1; v-myc avian myelocytomatosis v ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MYCL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MYCL. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MYCL |
Name | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog |
Aliases | LMYC; l-myc protein; myc-related gene from lung cancer; oncogene lmyc; MYCL1; v-myc avian myelocytomatosis v ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MYCL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MYCL |
Name | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog |
Aliases | LMYC; l-myc protein; myc-related gene from lung cancer; oncogene lmyc; MYCL1; v-myc avian myelocytomatosis v ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MYCL expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MYCL |
Name | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog |
Aliases | LMYC; l-myc protein; myc-related gene from lung cancer; oncogene lmyc; MYCL1; v-myc avian myelocytomatosis v ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MYCL and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MYCL |
Name | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog |
Aliases | LMYC; l-myc protein; myc-related gene from lung cancer; oncogene lmyc; MYCL1; v-myc avian myelocytomatosis v ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MYCL collected from DrugBank database. |
There is no record. |