Summary | |
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Symbol | MYF6 |
Name | myogenic factor 6 (herculin) |
Aliases | MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ...... |
Chromosomal Location | 12q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF01586 Myogenic Basic domain PF00010 Helix-loop-helix DNA-binding domain |
Function |
Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. |
Biological Process |
GO:0000768 syncytium formation by plasma membrane fusion GO:0001756 somitogenesis GO:0003002 regionalization GO:0006949 syncytium formation GO:0007389 pattern specification process GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0007520 myoblast fusion GO:0009952 anterior/posterior pattern specification GO:0010720 positive regulation of cell development GO:0010830 regulation of myotube differentiation GO:0010831 positive regulation of myotube differentiation GO:0014706 striated muscle tissue development GO:0014902 myotube differentiation GO:0014904 myotube cell development GO:0016202 regulation of striated muscle tissue development GO:0031099 regeneration GO:0035282 segmentation GO:0035914 skeletal muscle cell differentiation GO:0042246 tissue regeneration GO:0042692 muscle cell differentiation GO:0042693 muscle cell fate commitment GO:0043403 skeletal muscle tissue regeneration GO:0045165 cell fate commitment GO:0045445 myoblast differentiation GO:0045661 regulation of myoblast differentiation GO:0045663 positive regulation of myoblast differentiation GO:0045844 positive regulation of striated muscle tissue development GO:0048634 regulation of muscle organ development GO:0048636 positive regulation of muscle organ development GO:0048641 regulation of skeletal muscle tissue development GO:0048643 positive regulation of skeletal muscle tissue development GO:0048644 muscle organ morphogenesis GO:0048741 skeletal muscle fiber development GO:0048742 regulation of skeletal muscle fiber development GO:0048743 positive regulation of skeletal muscle fiber development GO:0048747 muscle fiber development GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051149 positive regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051155 positive regulation of striated muscle cell differentiation GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0060142 regulation of syncytium formation by plasma membrane fusion GO:0060143 positive regulation of syncytium formation by plasma membrane fusion GO:0060415 muscle tissue morphogenesis GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0061053 somite development GO:1901739 regulation of myoblast fusion GO:1901741 positive regulation of myoblast fusion GO:1901861 regulation of muscle tissue development GO:1901863 positive regulation of muscle tissue development |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0046982 protein heterodimerization activity GO:0070888 E-box binding |
Cellular Component |
GO:0005667 transcription factor complex GO:0044798 nuclear transcription factor complex GO:0090575 RNA polymerase II transcription factor complex |
KEGG | - |
Reactome |
R-HSA-375170: CDO in myogenesis R-HSA-1266738: Developmental Biology R-HSA-525793: Myogenesis |
Summary | |
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Symbol | MYF6 |
Name | myogenic factor 6 (herculin) |
Aliases | MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ...... |
Chromosomal Location | 12q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MYF6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MYF6 |
Name | myogenic factor 6 (herculin) |
Aliases | MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ...... |
Chromosomal Location | 12q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MYF6 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | MYF6 |
Name | myogenic factor 6 (herculin) |
Aliases | MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ...... |
Chromosomal Location | 12q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MYF6 in various data sets.
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Points in the above scatter plot represent the mutation difference of MYF6 in various data sets.
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Summary | |
---|---|
Symbol | MYF6 |
Name | myogenic factor 6 (herculin) |
Aliases | MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ...... |
Chromosomal Location | 12q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MYF6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MYF6 |
Name | myogenic factor 6 (herculin) |
Aliases | MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ...... |
Chromosomal Location | 12q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MYF6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MYF6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MYF6 |
Name | myogenic factor 6 (herculin) |
Aliases | MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ...... |
Chromosomal Location | 12q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MYF6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MYF6 |
Name | myogenic factor 6 (herculin) |
Aliases | MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ...... |
Chromosomal Location | 12q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MYF6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MYF6 |
Name | myogenic factor 6 (herculin) |
Aliases | MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ...... |
Chromosomal Location | 12q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MYF6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MYF6 |
Name | myogenic factor 6 (herculin) |
Aliases | MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ...... |
Chromosomal Location | 12q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MYF6 collected from DrugBank database. |
There is no record. |