Summary | |
---|---|
Symbol | MYH11 |
Name | myosin, heavy chain 11, smooth muscle |
Aliases | SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils. |
Domain |
PF00063 Myosin head (motor domain) PF02736 Myosin N-terminal SH3-like domain PF01576 Myosin tail |
Function |
Muscle contraction. |
Biological Process |
GO:0003012 muscle system process GO:0006936 muscle contraction GO:0006939 smooth muscle contraction GO:0007507 heart development GO:0010927 cellular component assembly involved in morphogenesis GO:0014706 striated muscle tissue development GO:0014866 skeletal myofibril assembly GO:0030198 extracellular matrix organization GO:0030239 myofibril assembly GO:0030241 skeletal muscle myosin thick filament assembly GO:0031032 actomyosin structure organization GO:0031033 myosin filament organization GO:0031034 myosin filament assembly GO:0035051 cardiocyte differentiation GO:0042692 muscle cell differentiation GO:0043062 extracellular structure organization GO:0048251 elastic fiber assembly GO:0048738 cardiac muscle tissue development GO:0048739 cardiac muscle fiber development GO:0048747 muscle fiber development GO:0051146 striated muscle cell differentiation GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0055006 cardiac cell development GO:0055007 cardiac muscle cell differentiation GO:0055013 cardiac muscle cell development GO:0060537 muscle tissue development GO:0071688 striated muscle myosin thick filament assembly GO:0085029 extracellular matrix assembly |
Molecular Function |
GO:0003774 motor activity GO:0003779 actin binding GO:0005516 calmodulin binding GO:0008307 structural constituent of muscle GO:0051015 actin filament binding |
Cellular Component |
GO:0005859 muscle myosin complex GO:0015629 actin cytoskeleton GO:0016459 myosin complex GO:0016460 myosin II complex GO:0032982 myosin filament GO:0042470 melanosome GO:0043292 contractile fiber GO:0044449 contractile fiber part GO:0048770 pigment granule |
KEGG |
hsa04270 Vascular smooth muscle contraction hsa04530 Tight junction |
Reactome |
R-HSA-422475: Axon guidance R-HSA-1266738: Developmental Biology R-HSA-2682334: EPH-Ephrin signaling R-HSA-3928663: EPHA-mediated growth cone collapse R-HSA-397014: Muscle contraction R-HSA-195258: RHO GTPase Effectors R-HSA-5627117: RHO GTPases Activate ROCKs R-HSA-5625900: RHO GTPases activate CIT R-HSA-5627123: RHO GTPases activate PAKs R-HSA-5625740: RHO GTPases activate PKNs R-HSA-400685: Sema4D in semaphorin signaling R-HSA-416572: Sema4D induced cell migration and growth-cone collapse R-HSA-373755: Semaphorin interactions R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases R-HSA-445355: Smooth Muscle Contraction |
Summary | |
---|---|
Symbol | MYH11 |
Name | myosin, heavy chain 11, smooth muscle |
Aliases | SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MYH11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MYH11 |
Name | myosin, heavy chain 11, smooth muscle |
Aliases | SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of MYH11 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | MYH11 |
Name | myosin, heavy chain 11, smooth muscle |
Aliases | SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MYH11 in various data sets.
|
Points in the above scatter plot represent the mutation difference of MYH11 in various data sets.
|
Summary | |
---|---|
Symbol | MYH11 |
Name | myosin, heavy chain 11, smooth muscle |
Aliases | SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MYH11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MYH11 |
Name | myosin, heavy chain 11, smooth muscle |
Aliases | SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MYH11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MYH11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MYH11 |
Name | myosin, heavy chain 11, smooth muscle |
Aliases | SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MYH11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MYH11 |
Name | myosin, heavy chain 11, smooth muscle |
Aliases | SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MYH11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MYH11 |
Name | myosin, heavy chain 11, smooth muscle |
Aliases | SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MYH11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MYH11 |
Name | myosin, heavy chain 11, smooth muscle |
Aliases | SMMHC; SMHC; myosin, heavy polypeptide 11, smooth muscle; AAT4; FAA4; myosin heavy chain 11; myosin heavy ch ...... |
Chromosomal Location | 16p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MYH11 collected from DrugBank database. |
Details on drugs targeting MYH11.
|