Summary | |
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Symbol | MYH6 |
Name | myosin, heavy chain 6, cardiac muscle, alpha |
Aliases | cardiomyopathy, hypertrophic 1; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertro ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. |
Domain |
PF00063 Myosin head (motor domain) PF02736 Myosin N-terminal SH3-like domain PF01576 Myosin tail |
Function |
Muscle contraction. |
Biological Process |
GO:0001701 in utero embryonic development GO:0002026 regulation of the force of heart contraction GO:0002027 regulation of heart rate GO:0003007 heart morphogenesis GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003015 heart process GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003208 cardiac ventricle morphogenesis GO:0003209 cardiac atrium morphogenesis GO:0003228 atrial cardiac muscle tissue development GO:0003229 ventricular cardiac muscle tissue development GO:0003230 cardiac atrium development GO:0003231 cardiac ventricle development GO:0003299 muscle hypertrophy in response to stress GO:0003300 cardiac muscle hypertrophy GO:0006470 protein dephosphorylation GO:0006936 muscle contraction GO:0006941 striated muscle contraction GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007507 heart development GO:0007512 adult heart development GO:0007517 muscle organ development GO:0007522 visceral muscle development GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0008217 regulation of blood pressure GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0010927 cellular component assembly involved in morphogenesis GO:0014706 striated muscle tissue development GO:0014887 cardiac muscle adaptation GO:0014888 striated muscle adaptation GO:0014896 muscle hypertrophy GO:0014897 striated muscle hypertrophy GO:0014898 cardiac muscle hypertrophy in response to stress GO:0016055 Wnt signaling pathway GO:0016311 dephosphorylation GO:0030048 actin filament-based movement GO:0030049 muscle filament sliding GO:0030239 myofibril assembly GO:0030509 BMP signaling pathway GO:0031032 actomyosin structure organization GO:0033275 actin-myosin filament sliding GO:0035051 cardiocyte differentiation GO:0035265 organ growth GO:0042278 purine nucleoside metabolic process GO:0042692 muscle cell differentiation GO:0043462 regulation of ATPase activity GO:0043500 muscle adaptation GO:0044057 regulation of system process GO:0045214 sarcomere organization GO:0046034 ATP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0046620 regulation of organ growth GO:0048638 regulation of developmental growth GO:0048644 muscle organ morphogenesis GO:0048738 cardiac muscle tissue development GO:0048739 cardiac muscle fiber development GO:0048747 muscle fiber development GO:0051146 striated muscle cell differentiation GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0055006 cardiac cell development GO:0055007 cardiac muscle cell differentiation GO:0055008 cardiac muscle tissue morphogenesis GO:0055009 atrial cardiac muscle tissue morphogenesis GO:0055010 ventricular cardiac muscle tissue morphogenesis GO:0055013 cardiac muscle cell development GO:0060047 heart contraction GO:0060048 cardiac muscle contraction GO:0060070 canonical Wnt signaling pathway GO:0060415 muscle tissue morphogenesis GO:0060419 heart growth GO:0060420 regulation of heart growth GO:0060537 muscle tissue development GO:0070252 actin-mediated cell contraction GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0198738 cell-cell signaling by wnt GO:1901657 glycosyl compound metabolic process GO:1903522 regulation of blood circulation |
Molecular Function |
GO:0000146 microfilament motor activity GO:0003774 motor activity GO:0003779 actin binding GO:0004721 phosphoprotein phosphatase activity GO:0004722 protein serine/threonine phosphatase activity GO:0005516 calmodulin binding GO:0016791 phosphatase activity GO:0016887 ATPase activity GO:0017018 myosin phosphatase activity GO:0030898 actin-dependent ATPase activity GO:0042578 phosphoric ester hydrolase activity GO:0042623 ATPase activity, coupled |
Cellular Component |
GO:0001725 stress fiber GO:0005859 muscle myosin complex GO:0015629 actin cytoskeleton GO:0016459 myosin complex GO:0016460 myosin II complex GO:0030016 myofibril GO:0030017 sarcomere GO:0030018 Z disc GO:0031674 I band GO:0032432 actin filament bundle GO:0032982 myosin filament GO:0042641 actomyosin GO:0043292 contractile fiber GO:0044449 contractile fiber part GO:0097517 contractile actin filament bundle |
KEGG |
hsa04260 Cardiac muscle contraction hsa04261 Adrenergic signaling in cardiomyocytes hsa04919 Thyroid hormone signaling pathway |
Reactome |
R-HSA-199991: Membrane Trafficking R-HSA-397014: Muscle contraction R-HSA-390522: Striated Muscle Contraction R-HSA-1445148: Translocation of GLUT4 to the plasma membrane R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | MYH6 |
Name | myosin, heavy chain 6, cardiac muscle, alpha |
Aliases | cardiomyopathy, hypertrophic 1; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertro ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MYH6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MYH6 |
Name | myosin, heavy chain 6, cardiac muscle, alpha |
Aliases | cardiomyopathy, hypertrophic 1; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertro ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MYH6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MYH6 |
Name | myosin, heavy chain 6, cardiac muscle, alpha |
Aliases | cardiomyopathy, hypertrophic 1; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertro ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MYH6 in various data sets.
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Points in the above scatter plot represent the mutation difference of MYH6 in various data sets.
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Summary | |
---|---|
Symbol | MYH6 |
Name | myosin, heavy chain 6, cardiac muscle, alpha |
Aliases | cardiomyopathy, hypertrophic 1; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertro ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MYH6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MYH6 |
Name | myosin, heavy chain 6, cardiac muscle, alpha |
Aliases | cardiomyopathy, hypertrophic 1; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertro ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MYH6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MYH6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MYH6 |
Name | myosin, heavy chain 6, cardiac muscle, alpha |
Aliases | cardiomyopathy, hypertrophic 1; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertro ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MYH6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MYH6 |
Name | myosin, heavy chain 6, cardiac muscle, alpha |
Aliases | cardiomyopathy, hypertrophic 1; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertro ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MYH6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MYH6 |
Name | myosin, heavy chain 6, cardiac muscle, alpha |
Aliases | cardiomyopathy, hypertrophic 1; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertro ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MYH6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MYH6 |
Name | myosin, heavy chain 6, cardiac muscle, alpha |
Aliases | cardiomyopathy, hypertrophic 1; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertro ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MYH6 collected from DrugBank database. |
There is no record. |