Summary | |
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Symbol | MYH9 |
Name | myosin, heavy chain 9, non-muscle |
Aliases | NMMHCA; NMHC-II-A; MHA; FTNS; EPSTS; nonmuscle myosin heavy chain II-A; DFNA17; myosin, heavy polypeptide 9, ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton Cytoplasm, cell cortex Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (PubMed:20052411). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (PubMed:27331610). |
Domain |
PF00063 Myosin head (motor domain) PF02736 Myosin N-terminal SH3-like domain PF01576 Myosin tail |
Function |
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10. |
Biological Process |
GO:0000212 meiotic spindle organization GO:0000226 microtubule cytoskeleton organization GO:0000768 syncytium formation by plasma membrane fusion GO:0000910 cytokinesis GO:0001525 angiogenesis GO:0001667 ameboidal-type cell migration GO:0001701 in utero embryonic development GO:0001767 establishment of lymphocyte polarity GO:0001768 establishment of T cell polarity GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0006509 membrane protein ectodomain proteolysis GO:0006909 phagocytosis GO:0006911 phagocytosis, engulfment GO:0006949 syncytium formation GO:0007159 leukocyte cell-cell adhesion GO:0007163 establishment or maintenance of cell polarity GO:0007229 integrin-mediated signaling pathway GO:0007520 myoblast fusion GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008360 regulation of cell shape GO:0010324 membrane invagination GO:0010631 epithelial cell migration GO:0010954 positive regulation of protein processing GO:0014902 myotube differentiation GO:0016485 protein processing GO:0022604 regulation of cell morphogenesis GO:0030010 establishment of cell polarity GO:0030048 actin filament-based movement GO:0030099 myeloid cell differentiation GO:0030168 platelet activation GO:0030220 platelet formation GO:0030224 monocyte differentiation GO:0031032 actomyosin structure organization GO:0031532 actin cytoskeleton reorganization GO:0032796 uropod organization GO:0032970 regulation of actin filament-based process GO:0033619 membrane protein proteolysis GO:0034109 homotypic cell-cell adhesion GO:0036344 platelet morphogenesis GO:0042110 T cell activation GO:0042692 muscle cell differentiation GO:0043534 blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0045862 positive regulation of proteolysis GO:0048514 blood vessel morphogenesis GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0050900 leukocyte migration GO:0051014 actin filament severing GO:0051146 striated muscle cell differentiation GO:0051293 establishment of spindle localization GO:0051295 establishment of meiotic spindle localization GO:0051321 meiotic cell cycle GO:0051604 protein maturation GO:0051640 organelle localization GO:0051653 spindle localization GO:0051656 establishment of organelle localization GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070527 platelet aggregation GO:0070613 regulation of protein processing GO:0071593 lymphocyte aggregation GO:0090130 tissue migration GO:0090132 epithelium migration GO:0099024 plasma membrane invagination GO:1900756 protein processing in phagocytic vesicle GO:1903046 meiotic cell cycle process GO:1903131 mononuclear cell differentiation GO:1903317 regulation of protein maturation GO:1903319 positive regulation of protein maturation GO:1903918 regulation of actin filament severing GO:1903919 negative regulation of actin filament severing GO:1903921 regulation of protein processing in phagocytic vesicle GO:1903923 positive regulation of protein processing in phagocytic vesicle |
Molecular Function |
GO:0000146 microfilament motor activity GO:0003774 motor activity GO:0003779 actin binding GO:0005516 calmodulin binding GO:0016887 ATPase activity GO:0030898 actin-dependent ATPase activity GO:0042623 ATPase activity, coupled GO:0043495 protein anchor GO:0043531 ADP binding GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0051015 actin filament binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0001725 stress fiber GO:0001726 ruffle GO:0001772 immunological synapse GO:0001931 uropod GO:0005819 spindle GO:0005826 actomyosin contractile ring GO:0005903 brush border GO:0005913 cell-cell adherens junction GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0005938 cell cortex GO:0008180 COP9 signalosome GO:0008305 integrin complex GO:0015629 actin cytoskeleton GO:0016459 myosin complex GO:0016460 myosin II complex GO:0030055 cell-substrate junction GO:0030863 cortical cytoskeleton GO:0030864 cortical actin cytoskeleton GO:0031252 cell leading edge GO:0031254 cell trailing edge GO:0031594 neuromuscular junction GO:0032153 cell division site GO:0032154 cleavage furrow GO:0032155 cell division site part GO:0032432 actin filament bundle GO:0032982 myosin filament GO:0042641 actomyosin GO:0043235 receptor complex GO:0044448 cell cortex part GO:0070938 contractile ring GO:0097513 myosin II filament GO:0097517 contractile actin filament bundle GO:0097610 cell surface furrow GO:0098636 protein complex involved in cell adhesion GO:0098802 plasma membrane receptor complex GO:0098862 cluster of actin-based cell projections GO:0099568 cytoplasmic region |
KEGG |
hsa04530 Tight junction hsa04810 Regulation of actin cytoskeleton |
Reactome |
R-HSA-422475: Axon guidance R-HSA-1266738: Developmental Biology R-HSA-2682334: EPH-Ephrin signaling R-HSA-3928663: EPHA-mediated growth cone collapse R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-195258: RHO GTPase Effectors R-HSA-5627117: RHO GTPases Activate ROCKs R-HSA-5625900: RHO GTPases activate CIT R-HSA-5627123: RHO GTPases activate PAKs R-HSA-5625740: RHO GTPases activate PKNs R-HSA-2029482: Regulation of actin dynamics for phagocytic cup formation R-HSA-400685: Sema4D in semaphorin signaling R-HSA-416572: Sema4D induced cell migration and growth-cone collapse R-HSA-373755: Semaphorin interactions R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases |
Summary | |
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Symbol | MYH9 |
Name | myosin, heavy chain 9, non-muscle |
Aliases | NMMHCA; NMHC-II-A; MHA; FTNS; EPSTS; nonmuscle myosin heavy chain II-A; DFNA17; myosin, heavy polypeptide 9, ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MYH9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MYH9 |
Name | myosin, heavy chain 9, non-muscle |
Aliases | NMMHCA; NMHC-II-A; MHA; FTNS; EPSTS; nonmuscle myosin heavy chain II-A; DFNA17; myosin, heavy polypeptide 9, ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MYH9 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MYH9 |
Name | myosin, heavy chain 9, non-muscle |
Aliases | NMMHCA; NMHC-II-A; MHA; FTNS; EPSTS; nonmuscle myosin heavy chain II-A; DFNA17; myosin, heavy polypeptide 9, ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MYH9 in various data sets.
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Points in the above scatter plot represent the mutation difference of MYH9 in various data sets.
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Summary | |
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Symbol | MYH9 |
Name | myosin, heavy chain 9, non-muscle |
Aliases | NMMHCA; NMHC-II-A; MHA; FTNS; EPSTS; nonmuscle myosin heavy chain II-A; DFNA17; myosin, heavy polypeptide 9, ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MYH9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MYH9 |
Name | myosin, heavy chain 9, non-muscle |
Aliases | NMMHCA; NMHC-II-A; MHA; FTNS; EPSTS; nonmuscle myosin heavy chain II-A; DFNA17; myosin, heavy polypeptide 9, ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MYH9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MYH9. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MYH9 |
Name | myosin, heavy chain 9, non-muscle |
Aliases | NMMHCA; NMHC-II-A; MHA; FTNS; EPSTS; nonmuscle myosin heavy chain II-A; DFNA17; myosin, heavy polypeptide 9, ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MYH9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MYH9 |
Name | myosin, heavy chain 9, non-muscle |
Aliases | NMMHCA; NMHC-II-A; MHA; FTNS; EPSTS; nonmuscle myosin heavy chain II-A; DFNA17; myosin, heavy polypeptide 9, ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MYH9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MYH9 |
Name | myosin, heavy chain 9, non-muscle |
Aliases | NMMHCA; NMHC-II-A; MHA; FTNS; EPSTS; nonmuscle myosin heavy chain II-A; DFNA17; myosin, heavy polypeptide 9, ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MYH9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MYH9 |
Name | myosin, heavy chain 9, non-muscle |
Aliases | NMMHCA; NMHC-II-A; MHA; FTNS; EPSTS; nonmuscle myosin heavy chain II-A; DFNA17; myosin, heavy polypeptide 9, ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MYH9 collected from DrugBank database. |
Details on drugs targeting MYH9.
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