Summary | |
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Symbol | MYO18A |
Name | myosin XVIIIA |
Aliases | KIAA0216; MysPDZ; SP-A receptor subunit SP-R210 alphaS; molecule associated with JAK3 N-terminus; myosin 18A ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Endoplasmic reticulum-Golgi intermediate compartment Cytoplasm, cytoskeleton. Note=Colocalizes with actin.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Note=Lacks the PDZ domain. Diffusely localized in the cytoplasm.; SUBCELLULAR LOCATION: Golgi apparatus. Golgi apparatus, trans-Golgi network. Note=Recruited to the Golgi apparatus by GOLPH3.; SUBCELLULAR LOCATION: Isoform 5: Cell surface |
Domain |
PF00063 Myosin head (motor domain) PF01576 Myosin tail PF00595 PDZ domain (Also known as DHR or GLGF) |
Function |
May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). |
Biological Process |
GO:0006900 membrane budding GO:0007030 Golgi organization GO:0007163 establishment or maintenance of cell polarity GO:0009306 protein secretion GO:0016050 vesicle organization GO:0030010 establishment of cell polarity GO:0031032 actomyosin structure organization GO:0048193 Golgi vesicle transport GO:0048194 Golgi vesicle budding GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0051047 positive regulation of secretion GO:0051222 positive regulation of protein transport GO:0090161 Golgi ribbon formation GO:0090162 establishment of epithelial cell polarity GO:0090164 asymmetric Golgi ribbon formation GO:1903532 positive regulation of secretion by cell GO:1904951 positive regulation of establishment of protein localization |
Molecular Function |
GO:0003779 actin binding GO:0043531 ADP binding GO:0051015 actin filament binding |
Cellular Component |
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO:0005802 trans-Golgi network GO:0015629 actin cytoskeleton GO:0016459 myosin complex GO:0031984 organelle subcompartment GO:0042641 actomyosin GO:0098791 Golgi subcompartment |
KEGG | - |
Reactome |
R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-1839124: FGFR1 mutant receptor activation R-HSA-1226099: Signaling by FGFR in disease R-HSA-5655302: Signaling by FGFR1 in disease R-HSA-1839117: Signaling by cytosolic FGFR1 fusion mutants |
Summary | |
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Symbol | MYO18A |
Name | myosin XVIIIA |
Aliases | KIAA0216; MysPDZ; SP-A receptor subunit SP-R210 alphaS; molecule associated with JAK3 N-terminus; myosin 18A ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MYO18A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MYO18A |
Name | myosin XVIIIA |
Aliases | KIAA0216; MysPDZ; SP-A receptor subunit SP-R210 alphaS; molecule associated with JAK3 N-terminus; myosin 18A ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MYO18A in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | MYO18A |
Name | myosin XVIIIA |
Aliases | KIAA0216; MysPDZ; SP-A receptor subunit SP-R210 alphaS; molecule associated with JAK3 N-terminus; myosin 18A ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MYO18A in various data sets.
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Points in the above scatter plot represent the mutation difference of MYO18A in various data sets.
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Summary | |
---|---|
Symbol | MYO18A |
Name | myosin XVIIIA |
Aliases | KIAA0216; MysPDZ; SP-A receptor subunit SP-R210 alphaS; molecule associated with JAK3 N-terminus; myosin 18A ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MYO18A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MYO18A |
Name | myosin XVIIIA |
Aliases | KIAA0216; MysPDZ; SP-A receptor subunit SP-R210 alphaS; molecule associated with JAK3 N-terminus; myosin 18A ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MYO18A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MYO18A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MYO18A |
Name | myosin XVIIIA |
Aliases | KIAA0216; MysPDZ; SP-A receptor subunit SP-R210 alphaS; molecule associated with JAK3 N-terminus; myosin 18A ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MYO18A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MYO18A |
Name | myosin XVIIIA |
Aliases | KIAA0216; MysPDZ; SP-A receptor subunit SP-R210 alphaS; molecule associated with JAK3 N-terminus; myosin 18A ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MYO18A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MYO18A |
Name | myosin XVIIIA |
Aliases | KIAA0216; MysPDZ; SP-A receptor subunit SP-R210 alphaS; molecule associated with JAK3 N-terminus; myosin 18A ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MYO18A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MYO18A |
Name | myosin XVIIIA |
Aliases | KIAA0216; MysPDZ; SP-A receptor subunit SP-R210 alphaS; molecule associated with JAK3 N-terminus; myosin 18A ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MYO18A collected from DrugBank database. |
There is no record. |