Summary | |
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Symbol | MYO18B |
Name | myosin XVIIIB |
Aliases | BK125H2.1; myosin 18B; myosin-XVIIIb; Unconventional myosin-XVIIIb |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Note=Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes. |
Domain |
PF00063 Myosin head (motor domain) |
Function |
May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
Biological Process | - |
Molecular Function |
GO:0003774 motor activity GO:0003779 actin binding |
Cellular Component |
GO:0015629 actin cytoskeleton GO:0016459 myosin complex GO:0016461 unconventional myosin complex GO:0030016 myofibril GO:0030017 sarcomere GO:0043292 contractile fiber GO:0044449 contractile fiber part |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | MYO18B |
Name | myosin XVIIIB |
Aliases | BK125H2.1; myosin 18B; myosin-XVIIIb; Unconventional myosin-XVIIIb |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MYO18B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MYO18B |
Name | myosin XVIIIB |
Aliases | BK125H2.1; myosin 18B; myosin-XVIIIb; Unconventional myosin-XVIIIb |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MYO18B in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | MYO18B |
Name | myosin XVIIIB |
Aliases | BK125H2.1; myosin 18B; myosin-XVIIIb; Unconventional myosin-XVIIIb |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MYO18B in various data sets.
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Points in the above scatter plot represent the mutation difference of MYO18B in various data sets.
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Summary | |
---|---|
Symbol | MYO18B |
Name | myosin XVIIIB |
Aliases | BK125H2.1; myosin 18B; myosin-XVIIIb; Unconventional myosin-XVIIIb |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MYO18B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MYO18B |
Name | myosin XVIIIB |
Aliases | BK125H2.1; myosin 18B; myosin-XVIIIb; Unconventional myosin-XVIIIb |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MYO18B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MYO18B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MYO18B |
Name | myosin XVIIIB |
Aliases | BK125H2.1; myosin 18B; myosin-XVIIIb; Unconventional myosin-XVIIIb |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MYO18B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MYO18B |
Name | myosin XVIIIB |
Aliases | BK125H2.1; myosin 18B; myosin-XVIIIb; Unconventional myosin-XVIIIb |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MYO18B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MYO18B |
Name | myosin XVIIIB |
Aliases | BK125H2.1; myosin 18B; myosin-XVIIIb; Unconventional myosin-XVIIIb |
Chromosomal Location | 22q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MYO18B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |