Summary | |
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Symbol | MYO7B |
Name | myosin VIIB |
Aliases | myosin-VIIb; Unconventional myosin-VIIb |
Chromosomal Location | 2q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton Cell projection, microvillus Note=Enriched in the microvilli of the intestinal brush border. |
Domain |
PF00373 FERM central domain PF00612 IQ calmodulin-binding motif PF00063 Myosin head (motor domain) PF00784 MyTH4 domain PF07653 Variant SH3 domain |
Function |
Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli (Probable). |
Biological Process |
GO:1904970 brush border assembly |
Molecular Function |
GO:0003774 motor activity GO:0003779 actin binding |
Cellular Component |
GO:0005902 microvillus GO:0005903 brush border GO:0015629 actin cytoskeleton GO:0016459 myosin complex GO:0045177 apical part of cell GO:0090651 apical cytoplasm GO:0098858 actin-based cell projection GO:0098862 cluster of actin-based cell projections |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | MYO7B |
Name | myosin VIIB |
Aliases | myosin-VIIb; Unconventional myosin-VIIb |
Chromosomal Location | 2q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MYO7B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MYO7B |
Name | myosin VIIB |
Aliases | myosin-VIIb; Unconventional myosin-VIIb |
Chromosomal Location | 2q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MYO7B in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | MYO7B |
Name | myosin VIIB |
Aliases | myosin-VIIb; Unconventional myosin-VIIb |
Chromosomal Location | 2q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MYO7B in various data sets.
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Points in the above scatter plot represent the mutation difference of MYO7B in various data sets.
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Summary | |
---|---|
Symbol | MYO7B |
Name | myosin VIIB |
Aliases | myosin-VIIb; Unconventional myosin-VIIb |
Chromosomal Location | 2q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MYO7B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MYO7B |
Name | myosin VIIB |
Aliases | myosin-VIIb; Unconventional myosin-VIIb |
Chromosomal Location | 2q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MYO7B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MYO7B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MYO7B |
Name | myosin VIIB |
Aliases | myosin-VIIb; Unconventional myosin-VIIb |
Chromosomal Location | 2q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MYO7B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MYO7B |
Name | myosin VIIB |
Aliases | myosin-VIIb; Unconventional myosin-VIIb |
Chromosomal Location | 2q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MYO7B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MYO7B |
Name | myosin VIIB |
Aliases | myosin-VIIb; Unconventional myosin-VIIb |
Chromosomal Location | 2q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MYO7B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |