Summary | |
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Symbol | MYOZ2 |
Name | myozenin 2 |
Aliases | C4orf5; chromosome 4 open reading frame 5; CMH16; FATZ-related protein 2; calcineurin-binding protein calsar ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, myofibril, sarcomere, Z line Note=Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle. |
Domain |
PF05556 Calcineurin-binding protein (Calsarcin) |
Function |
Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. |
Biological Process |
GO:0010927 cellular component assembly involved in morphogenesis GO:0030239 myofibril assembly GO:0031032 actomyosin structure organization GO:0042692 muscle cell differentiation GO:0051146 striated muscle cell differentiation GO:0055001 muscle cell development GO:0055002 striated muscle cell development |
Molecular Function |
GO:0003779 actin binding GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0030346 protein phosphatase 2B binding GO:0031433 telethonin binding GO:0051373 FATZ binding |
Cellular Component |
GO:0015629 actin cytoskeleton GO:0030016 myofibril GO:0030017 sarcomere GO:0030018 Z disc GO:0031674 I band GO:0043292 contractile fiber GO:0044449 contractile fiber part |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | MYOZ2 |
Name | myozenin 2 |
Aliases | C4orf5; chromosome 4 open reading frame 5; CMH16; FATZ-related protein 2; calcineurin-binding protein calsar ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MYOZ2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MYOZ2 |
Name | myozenin 2 |
Aliases | C4orf5; chromosome 4 open reading frame 5; CMH16; FATZ-related protein 2; calcineurin-binding protein calsar ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MYOZ2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MYOZ2 |
Name | myozenin 2 |
Aliases | C4orf5; chromosome 4 open reading frame 5; CMH16; FATZ-related protein 2; calcineurin-binding protein calsar ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MYOZ2 in various data sets.
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Points in the above scatter plot represent the mutation difference of MYOZ2 in various data sets.
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Summary | |
---|---|
Symbol | MYOZ2 |
Name | myozenin 2 |
Aliases | C4orf5; chromosome 4 open reading frame 5; CMH16; FATZ-related protein 2; calcineurin-binding protein calsar ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MYOZ2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MYOZ2 |
Name | myozenin 2 |
Aliases | C4orf5; chromosome 4 open reading frame 5; CMH16; FATZ-related protein 2; calcineurin-binding protein calsar ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MYOZ2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MYOZ2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MYOZ2 |
Name | myozenin 2 |
Aliases | C4orf5; chromosome 4 open reading frame 5; CMH16; FATZ-related protein 2; calcineurin-binding protein calsar ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MYOZ2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MYOZ2 |
Name | myozenin 2 |
Aliases | C4orf5; chromosome 4 open reading frame 5; CMH16; FATZ-related protein 2; calcineurin-binding protein calsar ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MYOZ2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MYOZ2 |
Name | myozenin 2 |
Aliases | C4orf5; chromosome 4 open reading frame 5; CMH16; FATZ-related protein 2; calcineurin-binding protein calsar ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MYOZ2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MYOZ2 |
Name | myozenin 2 |
Aliases | C4orf5; chromosome 4 open reading frame 5; CMH16; FATZ-related protein 2; calcineurin-binding protein calsar ...... |
Chromosomal Location | 4q26-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MYOZ2 collected from DrugBank database. |
There is no record. |