Summary | |
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Symbol | MYT1 |
Name | myelin transcription factor 1 |
Aliases | MYTI; ZC2HC4A; NZF2; neural zinc finger transcription factor 2; PLPB1; myelin transcription factor I; proteo ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF08474 Myelin transcription factor 1 PF01530 Zinc finger |
Function |
Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription. |
Biological Process | - |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | MYT1 |
Name | myelin transcription factor 1 |
Aliases | MYTI; ZC2HC4A; NZF2; neural zinc finger transcription factor 2; PLPB1; myelin transcription factor I; proteo ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MYT1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MYT1 |
Name | myelin transcription factor 1 |
Aliases | MYTI; ZC2HC4A; NZF2; neural zinc finger transcription factor 2; PLPB1; myelin transcription factor I; proteo ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MYT1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MYT1 |
Name | myelin transcription factor 1 |
Aliases | MYTI; ZC2HC4A; NZF2; neural zinc finger transcription factor 2; PLPB1; myelin transcription factor I; proteo ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MYT1 in various data sets.
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Points in the above scatter plot represent the mutation difference of MYT1 in various data sets.
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Summary | |
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Symbol | MYT1 |
Name | myelin transcription factor 1 |
Aliases | MYTI; ZC2HC4A; NZF2; neural zinc finger transcription factor 2; PLPB1; myelin transcription factor I; proteo ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MYT1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MYT1 |
Name | myelin transcription factor 1 |
Aliases | MYTI; ZC2HC4A; NZF2; neural zinc finger transcription factor 2; PLPB1; myelin transcription factor I; proteo ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MYT1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MYT1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MYT1 |
Name | myelin transcription factor 1 |
Aliases | MYTI; ZC2HC4A; NZF2; neural zinc finger transcription factor 2; PLPB1; myelin transcription factor I; proteo ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MYT1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MYT1 |
Name | myelin transcription factor 1 |
Aliases | MYTI; ZC2HC4A; NZF2; neural zinc finger transcription factor 2; PLPB1; myelin transcription factor I; proteo ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MYT1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MYT1 |
Name | myelin transcription factor 1 |
Aliases | MYTI; ZC2HC4A; NZF2; neural zinc finger transcription factor 2; PLPB1; myelin transcription factor I; proteo ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MYT1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MYT1 |
Name | myelin transcription factor 1 |
Aliases | MYTI; ZC2HC4A; NZF2; neural zinc finger transcription factor 2; PLPB1; myelin transcription factor I; proteo ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MYT1 collected from DrugBank database. |
There is no record. |