Summary | |
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Symbol | MZB1 |
Name | marginal zone B and B1 cell-specific protein |
Aliases | MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Endoplasmic reticulum lumen Secreted ; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm Note=Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957). |
Domain |
PF11938 TLR4 regulator and MIR-interacting MSAP |
Function |
Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. ; FUNCTION: Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance. |
Biological Process |
GO:0002377 immunoglobulin production GO:0002378 immunoglobulin biosynthetic process GO:0002440 production of molecular mediator of immune response GO:0002637 regulation of immunoglobulin production GO:0002639 positive regulation of immunoglobulin production GO:0002640 regulation of immunoglobulin biosynthetic process GO:0002642 positive regulation of immunoglobulin biosynthetic process GO:0002694 regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0010827 regulation of glucose transport GO:0010829 negative regulation of glucose transport GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0030888 regulation of B cell proliferation GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0033622 integrin activation GO:0042100 B cell proliferation GO:0042113 B cell activation GO:0043434 response to peptide hormone GO:0044381 glucose import in response to insulin stimulus GO:0046323 glucose import GO:0046324 regulation of glucose import GO:0046325 negative regulation of glucose import GO:0046651 lymphocyte proliferation GO:0050670 regulation of lymphocyte proliferation GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0051051 negative regulation of transport GO:0051249 regulation of lymphocyte activation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:1900076 regulation of cellular response to insulin stimulus GO:1900077 negative regulation of cellular response to insulin stimulus GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:2001273 regulation of glucose import in response to insulin stimulus GO:2001274 negative regulation of glucose import in response to insulin stimulus |
Molecular Function | - |
Cellular Component |
GO:0005788 endoplasmic reticulum lumen GO:0034663 endoplasmic reticulum chaperone complex |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | MZB1 |
Name | marginal zone B and B1 cell-specific protein |
Aliases | MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MZB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between MZB1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | MZB1 |
Name | marginal zone B and B1 cell-specific protein |
Aliases | MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MZB1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MZB1 |
Name | marginal zone B and B1 cell-specific protein |
Aliases | MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MZB1 in various data sets.
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There is no record. |
Summary | |
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Symbol | MZB1 |
Name | marginal zone B and B1 cell-specific protein |
Aliases | MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MZB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MZB1 |
Name | marginal zone B and B1 cell-specific protein |
Aliases | MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MZB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MZB1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MZB1 |
Name | marginal zone B and B1 cell-specific protein |
Aliases | MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MZB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MZB1 |
Name | marginal zone B and B1 cell-specific protein |
Aliases | MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MZB1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MZB1 |
Name | marginal zone B and B1 cell-specific protein |
Aliases | MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MZB1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MZB1 |
Name | marginal zone B and B1 cell-specific protein |
Aliases | MGC29506; HSPC190; pERp1; MEDA-7; plasma cell-induced ER protein 1; proapoptotic caspase adaptor protein; me ...... |
Chromosomal Location | 5q31.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MZB1 collected from DrugBank database. |
There is no record. |