Summary | |
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Symbol | NAMPT |
Name | nicotinamide phosphoribosyltransferase |
Aliases | visfatin; PBEF1; pre-B-cell colony enhancing factor 1; 1110035O14Rik; VF; NAmPRTase; pre-B cell-enhancing fa ...... |
Chromosomal Location | 7q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm Secreted Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. |
Domain |
PF04095 Nicotinate phosphoribosyltransferase (NAPRTase) family |
Function |
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). |
Biological Process |
GO:0006732 coenzyme metabolic process GO:0006733 oxidoreduction coenzyme metabolic process GO:0006766 vitamin metabolic process GO:0006767 water-soluble vitamin metabolic process GO:0006769 nicotinamide metabolic process GO:0007565 female pregnancy GO:0007623 circadian rhythm GO:0009108 coenzyme biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009435 NAD biosynthetic process GO:0009820 alkaloid metabolic process GO:0019359 nicotinamide nucleotide biosynthetic process GO:0019362 pyridine nucleotide metabolic process GO:0019363 pyridine nucleotide biosynthetic process GO:0019674 NAD metabolic process GO:0032922 circadian regulation of gene expression GO:0033002 muscle cell proliferation GO:0044706 multi-multicellular organism process GO:0046496 nicotinamide nucleotide metabolic process GO:0048511 rhythmic process GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0051186 cofactor metabolic process GO:0051188 cofactor biosynthetic process GO:0051767 nitric-oxide synthase biosynthetic process GO:0051769 regulation of nitric-oxide synthase biosynthetic process GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process GO:0072524 pyridine-containing compound metabolic process GO:0072525 pyridine-containing compound biosynthetic process GO:1901293 nucleoside phosphate biosynthetic process |
Molecular Function |
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity GO:0005125 cytokine activity GO:0008144 drug binding GO:0016757 transferase activity, transferring glycosyl groups GO:0016763 transferase activity, transferring pentosyl groups GO:0047280 nicotinamide phosphoribosyltransferase activity |
Cellular Component | - |
KEGG |
hsa04621 NOD-like receptor signaling pathway hsa00760 Nicotinate and nicotinamide metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-1368108: BMAL1 R-HSA-400253: Circadian Clock R-HSA-1430728: Metabolism R-HSA-196854: Metabolism of vitamins and cofactors R-HSA-196849: Metabolism of water-soluble vitamins and cofactors R-HSA-197264: Nicotinamide salvaging R-HSA-196807: Nicotinate metabolism |
Summary | |
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Symbol | NAMPT |
Name | nicotinamide phosphoribosyltransferase |
Aliases | visfatin; PBEF1; pre-B-cell colony enhancing factor 1; 1110035O14Rik; VF; NAmPRTase; pre-B cell-enhancing fa ...... |
Chromosomal Location | 7q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NAMPT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between NAMPT and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | NAMPT |
Name | nicotinamide phosphoribosyltransferase |
Aliases | visfatin; PBEF1; pre-B-cell colony enhancing factor 1; 1110035O14Rik; VF; NAmPRTase; pre-B cell-enhancing fa ...... |
Chromosomal Location | 7q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NAMPT in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NAMPT |
Name | nicotinamide phosphoribosyltransferase |
Aliases | visfatin; PBEF1; pre-B-cell colony enhancing factor 1; 1110035O14Rik; VF; NAmPRTase; pre-B cell-enhancing fa ...... |
Chromosomal Location | 7q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NAMPT in various data sets.
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There is no record. |
Summary | |
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Symbol | NAMPT |
Name | nicotinamide phosphoribosyltransferase |
Aliases | visfatin; PBEF1; pre-B-cell colony enhancing factor 1; 1110035O14Rik; VF; NAmPRTase; pre-B cell-enhancing fa ...... |
Chromosomal Location | 7q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NAMPT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NAMPT |
Name | nicotinamide phosphoribosyltransferase |
Aliases | visfatin; PBEF1; pre-B-cell colony enhancing factor 1; 1110035O14Rik; VF; NAmPRTase; pre-B cell-enhancing fa ...... |
Chromosomal Location | 7q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NAMPT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NAMPT. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NAMPT |
Name | nicotinamide phosphoribosyltransferase |
Aliases | visfatin; PBEF1; pre-B-cell colony enhancing factor 1; 1110035O14Rik; VF; NAmPRTase; pre-B cell-enhancing fa ...... |
Chromosomal Location | 7q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NAMPT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NAMPT |
Name | nicotinamide phosphoribosyltransferase |
Aliases | visfatin; PBEF1; pre-B-cell colony enhancing factor 1; 1110035O14Rik; VF; NAmPRTase; pre-B cell-enhancing fa ...... |
Chromosomal Location | 7q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NAMPT expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NAMPT |
Name | nicotinamide phosphoribosyltransferase |
Aliases | visfatin; PBEF1; pre-B-cell colony enhancing factor 1; 1110035O14Rik; VF; NAmPRTase; pre-B cell-enhancing fa ...... |
Chromosomal Location | 7q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NAMPT and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NAMPT |
Name | nicotinamide phosphoribosyltransferase |
Aliases | visfatin; PBEF1; pre-B-cell colony enhancing factor 1; 1110035O14Rik; VF; NAmPRTase; pre-B cell-enhancing fa ...... |
Chromosomal Location | 7q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NAMPT collected from DrugBank database. |
Details on drugs targeting NAMPT.
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