Summary | |
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Symbol | NANOG |
Name | Nanog homeobox |
Aliases | FLJ12581; FLJ40451; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; hNano ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00046 Homeobox domain |
Function |
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. |
Biological Process |
GO:0001704 formation of primary germ layer GO:0001706 endoderm formation GO:0001708 cell fate specification GO:0001711 endodermal cell fate commitment GO:0001714 endodermal cell fate specification GO:0007369 gastrulation GO:0007492 endoderm development GO:0019827 stem cell population maintenance GO:0035019 somatic stem cell population maintenance GO:0035987 endodermal cell differentiation GO:0045165 cell fate commitment GO:0060795 cell fate commitment involved in formation of primary germ layer GO:0098727 maintenance of cell number |
Molecular Function |
GO:0003714 transcription corepressor activity |
Cellular Component | - |
KEGG |
hsa04550 Signaling pathways regulating pluripotency of stem cells |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1266738: Developmental Biology R-HSA-168256: Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-2892247: POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892245: POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-449147: Signaling by Interleukins R-HSA-452723: Transcriptional regulation of pluripotent stem cells |
Summary | |
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Symbol | NANOG |
Name | Nanog homeobox |
Aliases | FLJ12581; FLJ40451; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; hNano ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NANOG and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between NANOG and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | NANOG |
Name | Nanog homeobox |
Aliases | FLJ12581; FLJ40451; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; hNano ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NANOG in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NANOG |
Name | Nanog homeobox |
Aliases | FLJ12581; FLJ40451; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; hNano ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NANOG in various data sets.
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Points in the above scatter plot represent the mutation difference of NANOG in various data sets.
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Summary | |
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Symbol | NANOG |
Name | Nanog homeobox |
Aliases | FLJ12581; FLJ40451; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; hNano ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NANOG. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NANOG |
Name | Nanog homeobox |
Aliases | FLJ12581; FLJ40451; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; hNano ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NANOG. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NANOG. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NANOG |
Name | Nanog homeobox |
Aliases | FLJ12581; FLJ40451; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; hNano ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NANOG. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NANOG |
Name | Nanog homeobox |
Aliases | FLJ12581; FLJ40451; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; hNano ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NANOG expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NANOG |
Name | Nanog homeobox |
Aliases | FLJ12581; FLJ40451; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; hNano ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NANOG and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NANOG |
Name | Nanog homeobox |
Aliases | FLJ12581; FLJ40451; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; hNano ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NANOG collected from DrugBank database. |
There is no record. |