Summary | |
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Symbol | NAPG |
Name | N-ethylmaleimide-sensitive factor attachment protein, gamma |
Aliases | gamma SNAP; GAMMASNAP; SNAP-gamma; soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachm ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Peripheral membrane protein |
Domain | - |
Function |
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. |
Biological Process |
GO:0006891 intra-Golgi vesicle-mediated transport GO:0031647 regulation of protein stability GO:0048193 Golgi vesicle transport GO:0050821 protein stabilization GO:0061025 membrane fusion |
Molecular Function |
GO:0000149 SNARE binding GO:0005483 soluble NSF attachment protein activity GO:0019905 syntaxin binding |
Cellular Component |
GO:0005765 lysosomal membrane GO:0031201 SNARE complex GO:0043209 myelin sheath GO:0098852 lytic vacuole membrane |
KEGG | - |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6807878: COPI-mediated anterograde transport R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport R-HSA-199977: ER to Golgi Anterograde Transport R-HSA-8856688: Golgi-to-ER retrograde transport R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811438: Intra-Golgi traffic R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-6811440: Retrograde transport at the Trans-Golgi-Network R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | NAPG |
Name | N-ethylmaleimide-sensitive factor attachment protein, gamma |
Aliases | gamma SNAP; GAMMASNAP; SNAP-gamma; soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachm ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NAPG and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NAPG |
Name | N-ethylmaleimide-sensitive factor attachment protein, gamma |
Aliases | gamma SNAP; GAMMASNAP; SNAP-gamma; soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachm ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NAPG in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NAPG |
Name | N-ethylmaleimide-sensitive factor attachment protein, gamma |
Aliases | gamma SNAP; GAMMASNAP; SNAP-gamma; soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachm ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NAPG in various data sets.
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Points in the above scatter plot represent the mutation difference of NAPG in various data sets.
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Summary | |
---|---|
Symbol | NAPG |
Name | N-ethylmaleimide-sensitive factor attachment protein, gamma |
Aliases | gamma SNAP; GAMMASNAP; SNAP-gamma; soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachm ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NAPG. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NAPG |
Name | N-ethylmaleimide-sensitive factor attachment protein, gamma |
Aliases | gamma SNAP; GAMMASNAP; SNAP-gamma; soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachm ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NAPG. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NAPG. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NAPG |
Name | N-ethylmaleimide-sensitive factor attachment protein, gamma |
Aliases | gamma SNAP; GAMMASNAP; SNAP-gamma; soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachm ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NAPG. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NAPG |
Name | N-ethylmaleimide-sensitive factor attachment protein, gamma |
Aliases | gamma SNAP; GAMMASNAP; SNAP-gamma; soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachm ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NAPG expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NAPG |
Name | N-ethylmaleimide-sensitive factor attachment protein, gamma |
Aliases | gamma SNAP; GAMMASNAP; SNAP-gamma; soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachm ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NAPG and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NAPG |
Name | N-ethylmaleimide-sensitive factor attachment protein, gamma |
Aliases | gamma SNAP; GAMMASNAP; SNAP-gamma; soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachm ...... |
Chromosomal Location | 18p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NAPG collected from DrugBank database. |
There is no record. |