Summary | |
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Symbol | NAT14 |
Name | N-acetyltransferase 14 (GCN5-related, putative) |
Aliases | KLP1; K562 cells-derived leucine zipper-like protein 1; N-acetyltransferase 14; K562 cell-derived leucine-zi ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass membrane protein |
Domain |
PF00583 Acetyltransferase (GNAT) family |
Function |
Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro. |
Biological Process |
GO:0006352 DNA-templated transcription, initiation |
Molecular Function |
GO:0008080 N-acetyltransferase activity GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | NAT14 |
Name | N-acetyltransferase 14 (GCN5-related, putative) |
Aliases | KLP1; K562 cells-derived leucine zipper-like protein 1; N-acetyltransferase 14; K562 cell-derived leucine-zi ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NAT14 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NAT14 |
Name | N-acetyltransferase 14 (GCN5-related, putative) |
Aliases | KLP1; K562 cells-derived leucine zipper-like protein 1; N-acetyltransferase 14; K562 cell-derived leucine-zi ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NAT14 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | NAT14 |
Name | N-acetyltransferase 14 (GCN5-related, putative) |
Aliases | KLP1; K562 cells-derived leucine zipper-like protein 1; N-acetyltransferase 14; K562 cell-derived leucine-zi ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NAT14 in various data sets.
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Points in the above scatter plot represent the mutation difference of NAT14 in various data sets.
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Summary | |
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Symbol | NAT14 |
Name | N-acetyltransferase 14 (GCN5-related, putative) |
Aliases | KLP1; K562 cells-derived leucine zipper-like protein 1; N-acetyltransferase 14; K562 cell-derived leucine-zi ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NAT14. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NAT14 |
Name | N-acetyltransferase 14 (GCN5-related, putative) |
Aliases | KLP1; K562 cells-derived leucine zipper-like protein 1; N-acetyltransferase 14; K562 cell-derived leucine-zi ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NAT14. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NAT14. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NAT14 |
Name | N-acetyltransferase 14 (GCN5-related, putative) |
Aliases | KLP1; K562 cells-derived leucine zipper-like protein 1; N-acetyltransferase 14; K562 cell-derived leucine-zi ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NAT14. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NAT14 |
Name | N-acetyltransferase 14 (GCN5-related, putative) |
Aliases | KLP1; K562 cells-derived leucine zipper-like protein 1; N-acetyltransferase 14; K562 cell-derived leucine-zi ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NAT14 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NAT14 |
Name | N-acetyltransferase 14 (GCN5-related, putative) |
Aliases | KLP1; K562 cells-derived leucine zipper-like protein 1; N-acetyltransferase 14; K562 cell-derived leucine-zi ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NAT14 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NAT14 |
Name | N-acetyltransferase 14 (GCN5-related, putative) |
Aliases | KLP1; K562 cells-derived leucine zipper-like protein 1; N-acetyltransferase 14; K562 cell-derived leucine-zi ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NAT14 collected from DrugBank database. |
There is no record. |