Summary | |
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Symbol | NAT8L |
Name | N-acetyltransferase 8-like (GCN5-related, putative) |
Aliases | FLJ37478; Hcml3; N-acetyltransferase 8-like; CML3; NACED; NAT8-LIKE; NAA synthetase; camello-like protein 3; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Membrane Single-pass membrane protein Microsome membrane Single-pass membrane protein Mitochondrion membrane; Single-pass membrane protein. Rough endoplasmic reticulum membrane Single-pass membrane protein Note=Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment. |
Domain |
PF00583 Acetyltransferase (GNAT) family |
Function |
Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. |
Biological Process | - |
Molecular Function |
GO:0008080 N-acetyltransferase activity GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0017188 aspartate N-acetyltransferase activity |
Cellular Component |
GO:0005791 rough endoplasmic reticulum GO:0030867 rough endoplasmic reticulum membrane |
KEGG |
hsa00250 Alanine, aspartate and glutamate metabolism hsa01100 Metabolic pathways |
Reactome | - |
Summary | |
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Symbol | NAT8L |
Name | N-acetyltransferase 8-like (GCN5-related, putative) |
Aliases | FLJ37478; Hcml3; N-acetyltransferase 8-like; CML3; NACED; NAT8-LIKE; NAA synthetase; camello-like protein 3; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NAT8L and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NAT8L |
Name | N-acetyltransferase 8-like (GCN5-related, putative) |
Aliases | FLJ37478; Hcml3; N-acetyltransferase 8-like; CML3; NACED; NAT8-LIKE; NAA synthetase; camello-like protein 3; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NAT8L in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NAT8L |
Name | N-acetyltransferase 8-like (GCN5-related, putative) |
Aliases | FLJ37478; Hcml3; N-acetyltransferase 8-like; CML3; NACED; NAT8-LIKE; NAA synthetase; camello-like protein 3; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NAT8L in various data sets.
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Points in the above scatter plot represent the mutation difference of NAT8L in various data sets.
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Summary | |
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Symbol | NAT8L |
Name | N-acetyltransferase 8-like (GCN5-related, putative) |
Aliases | FLJ37478; Hcml3; N-acetyltransferase 8-like; CML3; NACED; NAT8-LIKE; NAA synthetase; camello-like protein 3; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NAT8L. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NAT8L |
Name | N-acetyltransferase 8-like (GCN5-related, putative) |
Aliases | FLJ37478; Hcml3; N-acetyltransferase 8-like; CML3; NACED; NAT8-LIKE; NAA synthetase; camello-like protein 3; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NAT8L. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NAT8L. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NAT8L |
Name | N-acetyltransferase 8-like (GCN5-related, putative) |
Aliases | FLJ37478; Hcml3; N-acetyltransferase 8-like; CML3; NACED; NAT8-LIKE; NAA synthetase; camello-like protein 3; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NAT8L. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NAT8L |
Name | N-acetyltransferase 8-like (GCN5-related, putative) |
Aliases | FLJ37478; Hcml3; N-acetyltransferase 8-like; CML3; NACED; NAT8-LIKE; NAA synthetase; camello-like protein 3; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NAT8L expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NAT8L |
Name | N-acetyltransferase 8-like (GCN5-related, putative) |
Aliases | FLJ37478; Hcml3; N-acetyltransferase 8-like; CML3; NACED; NAT8-LIKE; NAA synthetase; camello-like protein 3; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NAT8L and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NAT8L |
Name | N-acetyltransferase 8-like (GCN5-related, putative) |
Aliases | FLJ37478; Hcml3; N-acetyltransferase 8-like; CML3; NACED; NAT8-LIKE; NAA synthetase; camello-like protein 3; ...... |
Chromosomal Location | 4p16.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NAT8L collected from DrugBank database. |
There is no record. |