Summary | |
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Symbol | NCKAP1 |
Name | NCK-associated protein 1 |
Aliases | HEM2; NAP125; p125Nap1; membrane-associated protein HEM-2; NAP 1 |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass membrane protein Cytoplasmic side Cell projection, lamellipodium membrane Single-pass membrane protein Cytoplasmic side Note=At the interface between the lamellipodial actin meshwork and the membrane. |
Domain |
PF09735 Membrane-associated apoptosis protein |
Function |
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. |
Biological Process |
GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002431 Fc receptor mediated stimulatory signaling pathway GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006909 phagocytosis GO:0007015 actin filament organization GO:0007265 Ras protein signal transduction GO:0008064 regulation of actin polymerization or depolymerization GO:0008154 actin polymerization or depolymerization GO:0010591 regulation of lamellipodium assembly GO:0010592 positive regulation of lamellipodium assembly GO:0016601 Rac protein signal transduction GO:0030031 cell projection assembly GO:0030032 lamellipodium assembly GO:0030041 actin filament polymerization GO:0030832 regulation of actin filament length GO:0030833 regulation of actin filament polymerization GO:0030838 positive regulation of actin filament polymerization GO:0031334 positive regulation of protein complex assembly GO:0031346 positive regulation of cell projection organization GO:0032271 regulation of protein polymerization GO:0032273 positive regulation of protein polymerization GO:0032535 regulation of cellular component size GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0034314 Arp2/3 complex-mediated actin nucleation GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation GO:0038093 Fc receptor signaling pathway GO:0038094 Fc-gamma receptor signaling pathway GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0043254 regulation of protein complex assembly GO:0044089 positive regulation of cellular component biogenesis GO:0045010 actin nucleation GO:0048010 vascular endothelial growth factor receptor signaling pathway GO:0051125 regulation of actin nucleation GO:0051127 positive regulation of actin nucleation GO:0051258 protein polymerization GO:0051493 regulation of cytoskeleton organization GO:0051495 positive regulation of cytoskeleton organization GO:0060491 regulation of cell projection assembly GO:0090066 regulation of anatomical structure size GO:0097581 lamellipodium organization GO:1902743 regulation of lamellipodium organization GO:1902745 positive regulation of lamellipodium organization GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation |
Molecular Function |
GO:0017016 Ras GTPase binding GO:0017048 Rho GTPase binding GO:0031267 small GTPase binding GO:0048365 Rac GTPase binding GO:0051020 GTPase binding |
Cellular Component |
GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030027 lamellipodium GO:0030055 cell-substrate junction GO:0031209 SCAR complex GO:0031252 cell leading edge GO:0031253 cell projection membrane GO:0031256 leading edge membrane GO:0031258 lamellipodium membrane |
KEGG |
hsa04810 Regulation of actin cytoskeleton |
Reactome |
R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-195258: RHO GTPase Effectors R-HSA-5663213: RHO GTPases Activate WASPs and WAVEs R-HSA-2029482: Regulation of actin dynamics for phagocytic cup formation R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases R-HSA-194138: Signaling by VEGF R-HSA-4420097: VEGFA-VEGFR2 Pathway |
Summary | |
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Symbol | NCKAP1 |
Name | NCK-associated protein 1 |
Aliases | HEM2; NAP125; p125Nap1; membrane-associated protein HEM-2; NAP 1 |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NCKAP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NCKAP1 |
Name | NCK-associated protein 1 |
Aliases | HEM2; NAP125; p125Nap1; membrane-associated protein HEM-2; NAP 1 |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NCKAP1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NCKAP1 |
Name | NCK-associated protein 1 |
Aliases | HEM2; NAP125; p125Nap1; membrane-associated protein HEM-2; NAP 1 |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NCKAP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of NCKAP1 in various data sets.
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Summary | |
---|---|
Symbol | NCKAP1 |
Name | NCK-associated protein 1 |
Aliases | HEM2; NAP125; p125Nap1; membrane-associated protein HEM-2; NAP 1 |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NCKAP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NCKAP1 |
Name | NCK-associated protein 1 |
Aliases | HEM2; NAP125; p125Nap1; membrane-associated protein HEM-2; NAP 1 |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NCKAP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NCKAP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NCKAP1 |
Name | NCK-associated protein 1 |
Aliases | HEM2; NAP125; p125Nap1; membrane-associated protein HEM-2; NAP 1 |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NCKAP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NCKAP1 |
Name | NCK-associated protein 1 |
Aliases | HEM2; NAP125; p125Nap1; membrane-associated protein HEM-2; NAP 1 |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NCKAP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NCKAP1 |
Name | NCK-associated protein 1 |
Aliases | HEM2; NAP125; p125Nap1; membrane-associated protein HEM-2; NAP 1 |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NCKAP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |