Browse NCOR1

Summary
SymbolNCOR1
Namenuclear receptor corepressor 1
Aliases N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF15784 G-protein pathway suppressor 2-interacting domain
PF00249 Myb-like DNA-binding domain
Function

Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0001933 negative regulation of protein phosphorylation
GO:0006090 pyruvate metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006096 glycolytic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006110 regulation of glycolytic process
GO:0006140 regulation of nucleotide metabolic process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006417 regulation of translation
GO:0006732 coenzyme metabolic process
GO:0006733 oxidoreduction coenzyme metabolic process
GO:0006757 ATP generation from ADP
GO:0006820 anion transport
GO:0006869 lipid transport
GO:0007051 spindle organization
GO:0007254 JNK cascade
GO:0007623 circadian rhythm
GO:0009116 nucleoside metabolic process
GO:0009118 regulation of nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009123 nucleoside monophosphate metabolic process
GO:0009126 purine nucleoside monophosphate metabolic process
GO:0009132 nucleoside diphosphate metabolic process
GO:0009135 purine nucleoside diphosphate metabolic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009144 purine nucleoside triphosphate metabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009161 ribonucleoside monophosphate metabolic process
GO:0009167 purine ribonucleoside monophosphate metabolic process
GO:0009179 purine ribonucleoside diphosphate metabolic process
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009205 purine ribonucleoside triphosphate metabolic process
GO:0009894 regulation of catabolic process
GO:0010608 posttranscriptional regulation of gene expression
GO:0010876 lipid localization
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0015908 fatty acid transport
GO:0016052 carbohydrate catabolic process
GO:0016441 posttranscriptional gene silencing
GO:0016458 gene silencing
GO:0017148 negative regulation of translation
GO:0019362 pyridine nucleotide metabolic process
GO:0031047 gene silencing by RNA
GO:0031050 dsRNA fragmentation
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032368 regulation of lipid transport
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0034248 regulation of cellular amide metabolic process
GO:0034249 negative regulation of cellular amide metabolic process
GO:0034250 positive regulation of cellular amide metabolic process
GO:0035194 posttranscriptional gene silencing by RNA
GO:0035195 gene silencing by miRNA
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0040029 regulation of gene expression, epigenetic
GO:0042278 purine nucleoside metabolic process
GO:0042326 negative regulation of phosphorylation
GO:0043331 response to dsRNA
GO:0043409 negative regulation of MAPK cascade
GO:0043467 regulation of generation of precursor metabolites and energy
GO:0043470 regulation of carbohydrate catabolic process
GO:0044070 regulation of anion transport
GO:0044723 single-organism carbohydrate metabolic process
GO:0044724 single-organism carbohydrate catabolic process
GO:0045727 positive regulation of translation
GO:0046031 ADP metabolic process
GO:0046034 ATP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046328 regulation of JNK cascade
GO:0046329 negative regulation of JNK cascade
GO:0046496 nicotinamide nucleotide metabolic process
GO:0046939 nucleotide phosphorylation
GO:0046942 carboxylic acid transport
GO:0048511 rhythmic process
GO:0051186 cofactor metabolic process
GO:0051193 regulation of cofactor metabolic process
GO:0051196 regulation of coenzyme metabolic process
GO:0051225 spindle assembly
GO:0051403 stress-activated MAPK cascade
GO:0060147 regulation of posttranscriptional gene silencing
GO:0060149 negative regulation of posttranscriptional gene silencing
GO:0060964 regulation of gene silencing by miRNA
GO:0060965 negative regulation of gene silencing by miRNA
GO:0060966 regulation of gene silencing by RNA
GO:0060967 negative regulation of gene silencing by RNA
GO:0060968 regulation of gene silencing
GO:0060969 negative regulation of gene silencing
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070303 negative regulation of stress-activated protein kinase signaling cascade
GO:0070918 production of small RNA involved in gene silencing by RNA
GO:0070920 regulation of production of small RNA involved in gene silencing by RNA
GO:0071359 cellular response to dsRNA
GO:0071407 cellular response to organic cyclic compound
GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter
GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter
GO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
GO:0072524 pyridine-containing compound metabolic process
GO:1900542 regulation of purine nucleotide metabolic process
GO:1901657 glycosyl compound metabolic process
GO:1902532 negative regulation of intracellular signal transduction
GO:1903578 regulation of ATP metabolic process
GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:2000191 regulation of fatty acid transport
Molecular Function GO:0001085 RNA polymerase II transcription factor binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0003714 transcription corepressor activity
GO:0008134 transcription factor binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0033613 activating transcription factor binding
GO:0035257 nuclear hormone receptor binding
GO:0042826 histone deacetylase binding
GO:0046966 thyroid hormone receptor binding
GO:0051427 hormone receptor binding
Cellular Component GO:0000118 histone deacetylase complex
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0005819 spindle
GO:0005874 microtubule
GO:0005876 spindle microtubule
GO:0016580 Sin3 complex
GO:0017053 transcriptional repressor complex
GO:0044454 nuclear chromosome part
GO:0070822 Sin3-type complex
> KEGG and Reactome Pathway
 
KEGG hsa04919 Thyroid hormone signaling pathway
Reactome R-HSA-5619507: Activation of HOX genes during differentiation
R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-1368108: BMAL1
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-400253: Circadian Clock
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-2173795: Downregulation of SMAD2/3
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3214815: HDACs deacetylate histones
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1592230: Mitochondrial biogenesis
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-1368071: NR1D1 (REV-ERBA) represses gene expression
R-HSA-1251985: Nuclear signaling by ERBB4
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-1989781: PPARA activates gene expression
R-HSA-1368082: RORA activates gene expression
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-162582: Signal Transduction
R-HSA-1236394: Signaling by ERBB4
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer
R-HSA-170834: Signaling by TGF-beta Receptor Complex
R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis
R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3
R-HSA-381340: Transcriptional regulation of white adipocyte differentiation
Summary
SymbolNCOR1
Namenuclear receptor corepressor 1
Aliases N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NCOR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between NCOR1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
23312906Glioma; MesotheliomaPromote immunityIn two non epithelial cancers (glioma and mesothelioma), we found that the epigenetic regulation of the NY-ESO1 gene requires the sequential recruitment of the HDAC1-mSin3a-NCOR, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a complexes.The NY-ESO1 gene is a cancer/testis antigen considered to be suitable target for the immunotherapy of human malignancies.
Summary
SymbolNCOR1
Namenuclear receptor corepressor 1
Aliases N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NCOR1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNCOR1
Namenuclear receptor corepressor 1
Aliases N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NCOR1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1180.669
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0510.973
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1750.89
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1780.534
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0760.978
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3090.932
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2330.543
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.460.805
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.050.981
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0540.974
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.3460.895
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0080.878
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NCOR1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.15.91.21
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1031033.3-23.30.423
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.44.13.30.61
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.5010.50.135
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.5012.50.485
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNCOR1
Namenuclear receptor corepressor 1
Aliases N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NCOR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNCOR1
Namenuclear receptor corepressor 1
Aliases N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NCOR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NCOR1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNCOR1
Namenuclear receptor corepressor 1
Aliases N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NCOR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNCOR1
Namenuclear receptor corepressor 1
Aliases N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NCOR1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNCOR1
Namenuclear receptor corepressor 1
Aliases N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NCOR1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNCOR1
Namenuclear receptor corepressor 1
Aliases N-CoR; hCIT529I10; hN-CoR; KIAA1047; MGC104216; PPP1R109; thyroid hormone- and retinoic acid receptor-associ ......
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NCOR1 collected from DrugBank database.
> Drugs from DrugBank database
 

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