Summary | |
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Symbol | NCR1 |
Name | natural cytotoxicity triggering receptor 1 |
Aliases | NK-p46; NKP46; CD335; LY94; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46); lymphocy ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein |
Domain | - |
Function |
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. |
Biological Process |
GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001910 regulation of leukocyte mediated cytotoxicity GO:0002228 natural killer cell mediated immunity GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002697 regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002715 regulation of natural killer cell mediated immunity GO:0006968 cellular defense response GO:0030101 natural killer cell activation GO:0031341 regulation of cell killing GO:0042267 natural killer cell mediated cytotoxicity GO:0042269 regulation of natural killer cell mediated cytotoxicity GO:0045088 regulation of innate immune response |
Molecular Function |
GO:0005057 receptor signaling protein activity |
Cellular Component |
GO:0016514 SWI/SNF complex GO:0070603 SWI/SNF superfamily-type complex GO:0090544 BAF-type complex |
KEGG |
hsa04650 Natural killer cell mediated cytotoxicity |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Summary | |
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Symbol | NCR1 |
Name | natural cytotoxicity triggering receptor 1 |
Aliases | NK-p46; NKP46; CD335; LY94; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46); lymphocy ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NCR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between NCR1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | NCR1 |
Name | natural cytotoxicity triggering receptor 1 |
Aliases | NK-p46; NKP46; CD335; LY94; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46); lymphocy ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NCR1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NCR1 |
Name | natural cytotoxicity triggering receptor 1 |
Aliases | NK-p46; NKP46; CD335; LY94; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46); lymphocy ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NCR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of NCR1 in various data sets.
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Summary | |
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Symbol | NCR1 |
Name | natural cytotoxicity triggering receptor 1 |
Aliases | NK-p46; NKP46; CD335; LY94; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46); lymphocy ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NCR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NCR1 |
Name | natural cytotoxicity triggering receptor 1 |
Aliases | NK-p46; NKP46; CD335; LY94; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46); lymphocy ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NCR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NCR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NCR1 |
Name | natural cytotoxicity triggering receptor 1 |
Aliases | NK-p46; NKP46; CD335; LY94; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46); lymphocy ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NCR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NCR1 |
Name | natural cytotoxicity triggering receptor 1 |
Aliases | NK-p46; NKP46; CD335; LY94; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46); lymphocy ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NCR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NCR1 |
Name | natural cytotoxicity triggering receptor 1 |
Aliases | NK-p46; NKP46; CD335; LY94; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46); lymphocy ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NCR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NCR1 |
Name | natural cytotoxicity triggering receptor 1 |
Aliases | NK-p46; NKP46; CD335; LY94; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46); lymphocy ...... |
Chromosomal Location | 19q13.42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NCR1 collected from DrugBank database. |
There is no record. |