Summary | |
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Symbol | NDST4 |
Name | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 |
Aliases | NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ...... |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus membrane Single-pass type II membrane protein |
Domain |
PF12062 heparan sulfate-N-deacetylase PF00685 Sulfotransferase domain |
Function |
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity). |
Biological Process |
GO:0006022 aminoglycan metabolic process GO:0006023 aminoglycan biosynthetic process GO:0006024 glycosaminoglycan biosynthetic process GO:0006029 proteoglycan metabolic process GO:0006790 sulfur compound metabolic process GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0015012 heparan sulfate proteoglycan biosynthetic process GO:0030166 proteoglycan biosynthetic process GO:0030201 heparan sulfate proteoglycan metabolic process GO:0030202 heparin metabolic process GO:0030203 glycosaminoglycan metabolic process GO:0030210 heparin biosynthetic process GO:0044272 sulfur compound biosynthetic process GO:1903510 mucopolysaccharide metabolic process |
Molecular Function |
GO:0008146 sulfotransferase activity GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity GO:0016782 transferase activity, transferring sulfur-containing groups GO:0019213 deacetylase activity GO:0034483 heparan sulfate sulfotransferase activity |
Cellular Component | - |
KEGG |
hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin hsa01100 Metabolic pathways |
Reactome |
R-HSA-1630316: Glycosaminoglycan metabolism R-HSA-2022928: HS-GAG biosynthesis R-HSA-1638091: Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates |
Summary | |
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Symbol | NDST4 |
Name | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 |
Aliases | NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ...... |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NDST4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NDST4 |
Name | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 |
Aliases | NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ...... |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NDST4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NDST4 |
Name | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 |
Aliases | NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ...... |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NDST4 in various data sets.
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Points in the above scatter plot represent the mutation difference of NDST4 in various data sets.
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Summary | |
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Symbol | NDST4 |
Name | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 |
Aliases | NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ...... |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NDST4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NDST4 |
Name | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 |
Aliases | NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ...... |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NDST4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NDST4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NDST4 |
Name | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 |
Aliases | NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ...... |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NDST4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NDST4 |
Name | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 |
Aliases | NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ...... |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NDST4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NDST4 |
Name | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 |
Aliases | NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ...... |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NDST4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NDST4 |
Name | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 |
Aliases | NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ...... |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NDST4 collected from DrugBank database. |
There is no record. |