Browse NDST4

Summary
SymbolNDST4
NameN-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
Aliases NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ......
Chromosomal Location4q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Golgi apparatus membrane Single-pass type II membrane protein
Domain PF12062 heparan sulfate-N-deacetylase
PF00685 Sulfotransferase domain
Function

Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity).

> Gene Ontology
 
Biological Process GO:0006022 aminoglycan metabolic process
GO:0006023 aminoglycan biosynthetic process
GO:0006024 glycosaminoglycan biosynthetic process
GO:0006029 proteoglycan metabolic process
GO:0006790 sulfur compound metabolic process
GO:0009100 glycoprotein metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0030166 proteoglycan biosynthetic process
GO:0030201 heparan sulfate proteoglycan metabolic process
GO:0030202 heparin metabolic process
GO:0030203 glycosaminoglycan metabolic process
GO:0030210 heparin biosynthetic process
GO:0044272 sulfur compound biosynthetic process
GO:1903510 mucopolysaccharide metabolic process
Molecular Function GO:0008146 sulfotransferase activity
GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity
GO:0016782 transferase activity, transferring sulfur-containing groups
GO:0019213 deacetylase activity
GO:0034483 heparan sulfate sulfotransferase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
hsa01100 Metabolic pathways
Reactome R-HSA-1630316: Glycosaminoglycan metabolism
R-HSA-2022928: HS-GAG biosynthesis
R-HSA-1638091: Heparan sulfate/heparin (HS-GAG) metabolism
R-HSA-1430728: Metabolism
R-HSA-71387: Metabolism of carbohydrates
Summary
SymbolNDST4
NameN-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
Aliases NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ......
Chromosomal Location4q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NDST4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolNDST4
NameN-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
Aliases NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ......
Chromosomal Location4q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NDST4 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNDST4
NameN-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
Aliases NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ......
Chromosomal Location4q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NDST4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4970.303
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0530.959
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.0580.385
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.7560.0246
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NDST4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.44.13.30.61
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211728.611.816.80.257
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131138.518.220.30.386
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.57.43.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.67.75.91
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNDST4
NameN-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
Aliases NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ......
Chromosomal Location4q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NDST4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNDST4
NameN-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
Aliases NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ......
Chromosomal Location4q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NDST4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NDST4.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNDST4
NameN-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
Aliases NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ......
Chromosomal Location4q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NDST4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNDST4
NameN-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
Aliases NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ......
Chromosomal Location4q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NDST4 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNDST4
NameN-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
Aliases NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ......
Chromosomal Location4q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NDST4 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNDST4
NameN-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
Aliases NDST-4; NHSST4; N-HSST 4; N-heparan sulfate sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferas ......
Chromosomal Location4q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NDST4 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.