Summary | |
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Symbol | NDUFA13 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 |
Aliases | CGI-39; CDA016; GRIM-19; GRIM19; B16.6; complex I B16.6 subunit; CI-B16.6; NADH-ubiquinone oxidoreductase B1 ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion inner membrane Single-pass membrane protein Matrix side. Nucleus Note=Localizes mainly in the mitochondrion (PubMed:12628925). May be translocated into the nucleus upon IFN/RA treatment. |
Domain |
PF06212 GRIM-19 protein |
Function |
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091). |
Biological Process |
GO:0001101 response to acid chemical GO:0001558 regulation of cell growth GO:0006091 generation of precursor metabolites and energy GO:0006119 oxidative phosphorylation GO:0006120 mitochondrial electron transport, NADH to ubiquinone GO:0006626 protein targeting to mitochondrion GO:0006839 mitochondrial transport GO:0007006 mitochondrial membrane organization GO:0007007 inner mitochondrial membrane organization GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0010257 NADH dehydrogenase complex assembly GO:0010950 positive regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0015980 energy derivation by oxidation of organic compounds GO:0016049 cell growth GO:0017038 protein import GO:0022900 electron transport chain GO:0022904 respiratory electron transport chain GO:0030308 negative regulation of cell growth GO:0032526 response to retinoic acid GO:0032981 mitochondrial respiratory chain complex I assembly GO:0033108 mitochondrial respiratory chain complex assembly GO:0035456 response to interferon-beta GO:0035458 cellular response to interferon-beta GO:0042176 regulation of protein catabolic process GO:0042278 purine nucleoside metabolic process GO:0042773 ATP synthesis coupled electron transport GO:0042775 mitochondrial ATP synthesis coupled electron transport GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0044743 intracellular protein transmembrane import GO:0045039 protein import into mitochondrial inner membrane GO:0045333 cellular respiration GO:0045732 positive regulation of protein catabolic process GO:0045862 positive regulation of proteolysis GO:0045926 negative regulation of growth GO:0046034 ATP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0065002 intracellular protein transmembrane transport GO:0070585 protein localization to mitochondrion GO:0071229 cellular response to acid chemical GO:0071300 cellular response to retinoic acid GO:0071396 cellular response to lipid GO:0071806 protein transmembrane transport GO:0072593 reactive oxygen species metabolic process GO:0072655 establishment of protein localization to mitochondrion GO:0072657 protein localization to membrane GO:0090150 establishment of protein localization to membrane GO:0090151 establishment of protein localization to mitochondrial membrane GO:0097031 mitochondrial respiratory chain complex I biogenesis GO:0097191 extrinsic apoptotic signaling pathway GO:0097193 intrinsic apoptotic signaling pathway GO:1901657 glycosyl compound metabolic process GO:1902532 negative regulation of intracellular signal transduction GO:1990542 mitochondrial transmembrane transport GO:2000116 regulation of cysteine-type endopeptidase activity GO:2001056 positive regulation of cysteine-type endopeptidase activity GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0003954 NADH dehydrogenase activity GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0016651 oxidoreductase activity, acting on NAD(P)H GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0050136 NADH dehydrogenase (quinone) activity |
Cellular Component |
GO:0005743 mitochondrial inner membrane GO:0005746 mitochondrial respiratory chain GO:0005747 mitochondrial respiratory chain complex I GO:0030964 NADH dehydrogenase complex GO:0044455 mitochondrial membrane part GO:0045271 respiratory chain complex I GO:0070469 respiratory chain GO:0098798 mitochondrial protein complex GO:0098800 inner mitochondrial membrane protein complex GO:0098803 respiratory chain complex GO:1990204 oxidoreductase complex |
KEGG |
hsa04723 Retrograde endocannabinoid signaling hsa00190 Oxidative phosphorylation hsa01100 Metabolic pathways |
Reactome |
R-HSA-6799198: Complex I biogenesis R-HSA-1430728: Metabolism R-HSA-611105: Respiratory electron transport R-HSA-163200: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1428517: The citric acid (TCA) cycle and respiratory electron transport |
Summary | |
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Symbol | NDUFA13 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 |
Aliases | CGI-39; CDA016; GRIM-19; GRIM19; B16.6; complex I B16.6 subunit; CI-B16.6; NADH-ubiquinone oxidoreductase B1 ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NDUFA13 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between NDUFA13 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | NDUFA13 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 |
Aliases | CGI-39; CDA016; GRIM-19; GRIM19; B16.6; complex I B16.6 subunit; CI-B16.6; NADH-ubiquinone oxidoreductase B1 ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NDUFA13 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NDUFA13 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 |
Aliases | CGI-39; CDA016; GRIM-19; GRIM19; B16.6; complex I B16.6 subunit; CI-B16.6; NADH-ubiquinone oxidoreductase B1 ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NDUFA13 in various data sets.
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Points in the above scatter plot represent the mutation difference of NDUFA13 in various data sets.
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Summary | |
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Symbol | NDUFA13 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 |
Aliases | CGI-39; CDA016; GRIM-19; GRIM19; B16.6; complex I B16.6 subunit; CI-B16.6; NADH-ubiquinone oxidoreductase B1 ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NDUFA13. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NDUFA13 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 |
Aliases | CGI-39; CDA016; GRIM-19; GRIM19; B16.6; complex I B16.6 subunit; CI-B16.6; NADH-ubiquinone oxidoreductase B1 ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NDUFA13. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NDUFA13. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NDUFA13 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 |
Aliases | CGI-39; CDA016; GRIM-19; GRIM19; B16.6; complex I B16.6 subunit; CI-B16.6; NADH-ubiquinone oxidoreductase B1 ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NDUFA13. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NDUFA13 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 |
Aliases | CGI-39; CDA016; GRIM-19; GRIM19; B16.6; complex I B16.6 subunit; CI-B16.6; NADH-ubiquinone oxidoreductase B1 ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NDUFA13 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NDUFA13 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 |
Aliases | CGI-39; CDA016; GRIM-19; GRIM19; B16.6; complex I B16.6 subunit; CI-B16.6; NADH-ubiquinone oxidoreductase B1 ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NDUFA13 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NDUFA13 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 |
Aliases | CGI-39; CDA016; GRIM-19; GRIM19; B16.6; complex I B16.6 subunit; CI-B16.6; NADH-ubiquinone oxidoreductase B1 ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NDUFA13 collected from DrugBank database. |
Details on drugs targeting NDUFA13.
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