Summary | |
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Symbol | NDUFA9 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa |
Aliases | SDR22E1; CI-39k; short chain dehydrogenase/reductase family 22E, member 1; complex I 39kDa subunit; NDUFS2L; ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion matrix |
Domain |
PF01370 NAD dependent epimerase/dehydratase family |
Function |
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. |
Biological Process |
GO:0006091 generation of precursor metabolites and energy GO:0006119 oxidative phosphorylation GO:0006120 mitochondrial electron transport, NADH to ubiquinone GO:0006732 coenzyme metabolic process GO:0006733 oxidoreduction coenzyme metabolic process GO:0006743 ubiquinone metabolic process GO:0006744 ubiquinone biosynthetic process GO:0006814 sodium ion transport GO:0009108 coenzyme biosynthetic process GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0010257 NADH dehydrogenase complex assembly GO:0015672 monovalent inorganic cation transport GO:0015980 energy derivation by oxidation of organic compounds GO:0022900 electron transport chain GO:0022904 respiratory electron transport chain GO:0032981 mitochondrial respiratory chain complex I assembly GO:0033108 mitochondrial respiratory chain complex assembly GO:0042180 cellular ketone metabolic process GO:0042181 ketone biosynthetic process GO:0042278 purine nucleoside metabolic process GO:0042773 ATP synthesis coupled electron transport GO:0042775 mitochondrial ATP synthesis coupled electron transport GO:0044283 small molecule biosynthetic process GO:0045333 cellular respiration GO:0046034 ATP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0051186 cofactor metabolic process GO:0051188 cofactor biosynthetic process GO:0097031 mitochondrial respiratory chain complex I biogenesis GO:1901004 ubiquinone-6 metabolic process GO:1901006 ubiquinone-6 biosynthetic process GO:1901657 glycosyl compound metabolic process GO:1901661 quinone metabolic process GO:1901663 quinone biosynthetic process |
Molecular Function |
GO:0003954 NADH dehydrogenase activity GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0016651 oxidoreductase activity, acting on NAD(P)H GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0048037 cofactor binding GO:0050136 NADH dehydrogenase (quinone) activity GO:0050662 coenzyme binding |
Cellular Component |
GO:0005743 mitochondrial inner membrane GO:0005746 mitochondrial respiratory chain GO:0005747 mitochondrial respiratory chain complex I GO:0005759 mitochondrial matrix GO:0030964 NADH dehydrogenase complex GO:0044455 mitochondrial membrane part GO:0045271 respiratory chain complex I GO:0070469 respiratory chain GO:0098798 mitochondrial protein complex GO:0098800 inner mitochondrial membrane protein complex GO:0098803 respiratory chain complex GO:1990204 oxidoreductase complex |
KEGG |
hsa04723 Retrograde endocannabinoid signaling hsa00190 Oxidative phosphorylation hsa01100 Metabolic pathways |
Reactome |
R-HSA-6799198: Complex I biogenesis R-HSA-1430728: Metabolism R-HSA-611105: Respiratory electron transport R-HSA-163200: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1428517: The citric acid (TCA) cycle and respiratory electron transport |
Summary | |
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Symbol | NDUFA9 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa |
Aliases | SDR22E1; CI-39k; short chain dehydrogenase/reductase family 22E, member 1; complex I 39kDa subunit; NDUFS2L; ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NDUFA9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NDUFA9 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa |
Aliases | SDR22E1; CI-39k; short chain dehydrogenase/reductase family 22E, member 1; complex I 39kDa subunit; NDUFS2L; ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NDUFA9 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NDUFA9 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa |
Aliases | SDR22E1; CI-39k; short chain dehydrogenase/reductase family 22E, member 1; complex I 39kDa subunit; NDUFS2L; ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NDUFA9 in various data sets.
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Points in the above scatter plot represent the mutation difference of NDUFA9 in various data sets.
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Summary | |
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Symbol | NDUFA9 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa |
Aliases | SDR22E1; CI-39k; short chain dehydrogenase/reductase family 22E, member 1; complex I 39kDa subunit; NDUFS2L; ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NDUFA9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NDUFA9 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa |
Aliases | SDR22E1; CI-39k; short chain dehydrogenase/reductase family 22E, member 1; complex I 39kDa subunit; NDUFS2L; ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NDUFA9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NDUFA9. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NDUFA9 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa |
Aliases | SDR22E1; CI-39k; short chain dehydrogenase/reductase family 22E, member 1; complex I 39kDa subunit; NDUFS2L; ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NDUFA9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NDUFA9 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa |
Aliases | SDR22E1; CI-39k; short chain dehydrogenase/reductase family 22E, member 1; complex I 39kDa subunit; NDUFS2L; ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NDUFA9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NDUFA9 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa |
Aliases | SDR22E1; CI-39k; short chain dehydrogenase/reductase family 22E, member 1; complex I 39kDa subunit; NDUFS2L; ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NDUFA9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NDUFA9 |
Name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa |
Aliases | SDR22E1; CI-39k; short chain dehydrogenase/reductase family 22E, member 1; complex I 39kDa subunit; NDUFS2L; ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NDUFA9 collected from DrugBank database. |
Details on drugs targeting NDUFA9.
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