Summary | |
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Symbol | NEFM |
Name | neurofilament, medium polypeptide |
Aliases | NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00038 Intermediate filament protein PF04732 Intermediate filament head (DNA binding) region |
Function |
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. |
Biological Process |
GO:0033693 neurofilament bundle assembly GO:0045103 intermediate filament-based process GO:0045104 intermediate filament cytoskeleton organization GO:0045109 intermediate filament organization GO:0045110 intermediate filament bundle assembly GO:0060052 neurofilament cytoskeleton organization GO:0061564 axon development |
Molecular Function |
GO:0005200 structural constituent of cytoskeleton GO:0008017 microtubule binding GO:0015631 tubulin binding |
Cellular Component |
GO:0005882 intermediate filament GO:0005883 neurofilament GO:0016234 inclusion body GO:0030424 axon GO:0045111 intermediate filament cytoskeleton GO:0097418 neurofibrillary tangle |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | NEFM |
Name | neurofilament, medium polypeptide |
Aliases | NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NEFM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NEFM |
Name | neurofilament, medium polypeptide |
Aliases | NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NEFM in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | NEFM |
Name | neurofilament, medium polypeptide |
Aliases | NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NEFM in various data sets.
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Points in the above scatter plot represent the mutation difference of NEFM in various data sets.
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Summary | |
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Symbol | NEFM |
Name | neurofilament, medium polypeptide |
Aliases | NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NEFM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NEFM |
Name | neurofilament, medium polypeptide |
Aliases | NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NEFM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NEFM. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NEFM |
Name | neurofilament, medium polypeptide |
Aliases | NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NEFM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NEFM |
Name | neurofilament, medium polypeptide |
Aliases | NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NEFM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NEFM |
Name | neurofilament, medium polypeptide |
Aliases | NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NEFM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NEFM |
Name | neurofilament, medium polypeptide |
Aliases | NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ...... |
Chromosomal Location | 8p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NEFM collected from DrugBank database. |
There is no record. |