Browse NEFM

Summary
SymbolNEFM
Nameneurofilament, medium polypeptide
Aliases NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ......
Chromosomal Location8p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF00038 Intermediate filament protein
PF04732 Intermediate filament head (DNA binding) region
Function

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.

> Gene Ontology
 
Biological Process GO:0033693 neurofilament bundle assembly
GO:0045103 intermediate filament-based process
GO:0045104 intermediate filament cytoskeleton organization
GO:0045109 intermediate filament organization
GO:0045110 intermediate filament bundle assembly
GO:0060052 neurofilament cytoskeleton organization
GO:0061564 axon development
Molecular Function GO:0005200 structural constituent of cytoskeleton
GO:0008017 microtubule binding
GO:0015631 tubulin binding
Cellular Component GO:0005882 intermediate filament
GO:0005883 neurofilament
GO:0016234 inclusion body
GO:0030424 axon
GO:0045111 intermediate filament cytoskeleton
GO:0097418 neurofibrillary tangle
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolNEFM
Nameneurofilament, medium polypeptide
Aliases NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ......
Chromosomal Location8p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NEFM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolNEFM
Nameneurofilament, medium polypeptide
Aliases NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ......
Chromosomal Location8p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NEFM in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNEFM
Nameneurofilament, medium polypeptide
Aliases NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ......
Chromosomal Location8p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NEFM in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0810.888
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2920.754
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0740.926
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.7330.253
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.8580.579
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.5830.732
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3490.701
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.7270.603
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.260.873
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.8780.442
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-1.1890.423
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.5650.154
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NEFM in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.82.712.10.0439
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.83.411.40.0746
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.35.98.40.613
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNEFM
Nameneurofilament, medium polypeptide
Aliases NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ......
Chromosomal Location8p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NEFM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNEFM
Nameneurofilament, medium polypeptide
Aliases NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ......
Chromosomal Location8p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NEFM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NEFM.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNEFM
Nameneurofilament, medium polypeptide
Aliases NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ......
Chromosomal Location8p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NEFM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNEFM
Nameneurofilament, medium polypeptide
Aliases NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ......
Chromosomal Location8p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NEFM expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNEFM
Nameneurofilament, medium polypeptide
Aliases NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ......
Chromosomal Location8p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NEFM and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNEFM
Nameneurofilament, medium polypeptide
Aliases NFM; NF-M; NEF3; neurofilament, medium polypeptide 150kDa; 160 kDa neurofilament protein; neurofilament 3; n ......
Chromosomal Location8p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NEFM collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.