Summary | |
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Symbol | NEK10 |
Name | NIMA-related kinase 10 |
Aliases | FLJ32685; NIMA (never in mitosis gene a)- related kinase 10; never in mitosis A-related kinase 10; nimA-rela ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00069 Protein kinase domain |
Function |
- |
Biological Process |
GO:0007059 chromosome segregation GO:0031952 regulation of protein autophosphorylation GO:0031954 positive regulation of protein autophosphorylation GO:0033674 positive regulation of kinase activity GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0044770 cell cycle phase transition GO:0044839 cell cycle G2/M phase transition GO:0045860 positive regulation of protein kinase activity GO:0046777 protein autophosphorylation GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:1901987 regulation of cell cycle phase transition GO:1902749 regulation of cell cycle G2/M phase transition |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity |
Cellular Component |
GO:0005813 centrosome GO:0061695 transferase complex, transferring phosphorus-containing groups GO:1902911 protein kinase complex |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | NEK10 |
Name | NIMA-related kinase 10 |
Aliases | FLJ32685; NIMA (never in mitosis gene a)- related kinase 10; never in mitosis A-related kinase 10; nimA-rela ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NEK10 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NEK10 |
Name | NIMA-related kinase 10 |
Aliases | FLJ32685; NIMA (never in mitosis gene a)- related kinase 10; never in mitosis A-related kinase 10; nimA-rela ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NEK10 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | NEK10 |
Name | NIMA-related kinase 10 |
Aliases | FLJ32685; NIMA (never in mitosis gene a)- related kinase 10; never in mitosis A-related kinase 10; nimA-rela ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NEK10 in various data sets.
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Points in the above scatter plot represent the mutation difference of NEK10 in various data sets.
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Summary | |
---|---|
Symbol | NEK10 |
Name | NIMA-related kinase 10 |
Aliases | FLJ32685; NIMA (never in mitosis gene a)- related kinase 10; never in mitosis A-related kinase 10; nimA-rela ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NEK10. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NEK10 |
Name | NIMA-related kinase 10 |
Aliases | FLJ32685; NIMA (never in mitosis gene a)- related kinase 10; never in mitosis A-related kinase 10; nimA-rela ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NEK10. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NEK10. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | NEK10 |
Name | NIMA-related kinase 10 |
Aliases | FLJ32685; NIMA (never in mitosis gene a)- related kinase 10; never in mitosis A-related kinase 10; nimA-rela ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NEK10. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NEK10 |
Name | NIMA-related kinase 10 |
Aliases | FLJ32685; NIMA (never in mitosis gene a)- related kinase 10; never in mitosis A-related kinase 10; nimA-rela ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NEK10 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NEK10 |
Name | NIMA-related kinase 10 |
Aliases | FLJ32685; NIMA (never in mitosis gene a)- related kinase 10; never in mitosis A-related kinase 10; nimA-rela ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NEK10 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NEK10 |
Name | NIMA-related kinase 10 |
Aliases | FLJ32685; NIMA (never in mitosis gene a)- related kinase 10; never in mitosis A-related kinase 10; nimA-rela ...... |
Chromosomal Location | 3p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NEK10 collected from DrugBank database. |
There is no record. |