Summary | |
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Symbol | NEK2 |
Name | NIMA-related kinase 2 |
Aliases | NLK1; NEK2A; RP67; PPP1R111; HsPK 21; protein phosphatase 1, regulatory subunit 111; NIMA (never in mitosis ...... |
Chromosomal Location | 1q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Nucleus. Nucleus, nucleolus Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Chromosome, centromere Note=STK3/MST2 and SAV1 are required for its targeting to the centrosome. Colocalizes with SGO1 and MAD1L1 at the kinetochore. Not associated with kinetochore in the interphase but becomes associated with it upon the breakdown of the nuclear envelope. Has a nucleolar targeting/ retention activity via a coiled-coil domain at the C-terminal end.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Note=Predominantly cytoplasmic.; SUBCELLULAR LOCATION: Isoform 4: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly nuclear. |
Domain |
PF00069 Protein kinase domain |
Function |
Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly (PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143). Involved in the regulation of centrosome disjunction (PubMed:26220856). ; FUNCTION: Isoform 1: Phosphorylates and activates NEK11 in G1/S-arrested cells. ; FUNCTION: Isoform 2: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. |
Biological Process |
GO:0000070 mitotic sister chromatid segregation GO:0000086 G2/M transition of mitotic cell cycle GO:0000226 microtubule cytoskeleton organization GO:0000723 telomere maintenance GO:0000819 sister chromatid segregation GO:0001701 in utero embryonic development GO:0001824 blastocyst development GO:0006278 RNA-dependent DNA biosynthetic process GO:0007004 telomere maintenance via telomerase GO:0007051 spindle organization GO:0007059 chromosome segregation GO:0007067 mitotic nuclear division GO:0007088 regulation of mitotic nuclear division GO:0007098 centrosome cycle GO:0007100 mitotic centrosome separation GO:0007346 regulation of mitotic cell cycle GO:0008608 attachment of spindle microtubules to kinetochore GO:0010457 centriole-centriole cohesion GO:0010639 negative regulation of organelle organization GO:0010833 telomere maintenance via telomere lengthening GO:0016233 telomere capping GO:0030997 regulation of centriole-centriole cohesion GO:0031023 microtubule organizing center organization GO:0032200 telomere organization GO:0032204 regulation of telomere maintenance GO:0032206 positive regulation of telomere maintenance GO:0032210 regulation of telomere maintenance via telomerase GO:0032212 positive regulation of telomere maintenance via telomerase GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0032886 regulation of microtubule-based process GO:0033044 regulation of chromosome organization GO:0043392 negative regulation of DNA binding GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044839 cell cycle G2/M phase transition GO:0046602 regulation of mitotic centrosome separation GO:0046605 regulation of centrosome cycle GO:0046777 protein autophosphorylation GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051225 spindle assembly GO:0051297 centrosome organization GO:0051299 centrosome separation GO:0051321 meiotic cell cycle GO:0051493 regulation of cytoskeleton organization GO:0051494 negative regulation of cytoskeleton organization GO:0051783 regulation of nuclear division GO:0051972 regulation of telomerase activity GO:0051973 positive regulation of telomerase activity GO:0051983 regulation of chromosome segregation GO:0051988 regulation of attachment of spindle microtubules to kinetochore GO:0060249 anatomical structure homeostasis GO:0070507 regulation of microtubule cytoskeleton organization GO:0071897 DNA biosynthetic process GO:0090307 mitotic spindle assembly GO:0098813 nuclear chromosome segregation GO:1902850 microtubule cytoskeleton organization involved in mitosis GO:1903126 negative regulation of centriole-centriole cohesion GO:1904353 regulation of telomere capping GO:1904355 positive regulation of telomere capping GO:1904356 regulation of telomere maintenance via telomere lengthening GO:1904358 positive regulation of telomere maintenance via telomere lengthening GO:2000278 regulation of DNA biosynthetic process GO:2000573 positive regulation of DNA biosynthetic process GO:2001252 positive regulation of chromosome organization |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding |
Cellular Component |
GO:0000775 chromosome, centromeric region GO:0000776 kinetochore GO:0000777 condensed chromosome kinetochore GO:0000779 condensed chromosome, centromeric region GO:0000793 condensed chromosome GO:0000794 condensed nuclear chromosome GO:0000922 spindle pole GO:0005813 centrosome GO:0005819 spindle GO:0005874 microtubule GO:0030496 midbody GO:0098687 chromosomal region |
KEGG | - |
Reactome |
R-HSA-179409: APC-Cdc20 mediated degradation of Nek2A R-HSA-174143: APC/C-mediated degradation of cell cycle proteins R-HSA-176409: APC/C R-HSA-179419: APC R-HSA-8854518: AURKA Activation by TPX2 R-HSA-176814: Activation of APC/C and APC/C R-HSA-5620912: Anchoring of the basal body to the plasma membrane R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-380287: Centrosome maturation R-HSA-5617833: Cilium Assembly R-HSA-69275: G2/M Transition R-HSA-380259: Loss of Nlp from mitotic centrosomes R-HSA-380284: Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-453274: Mitotic G2-G2/M phases R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-380270: Recruitment of mitotic centrosome proteins and complexes R-HSA-2565942: Regulation of PLK1 Activity at G2/M Transition R-HSA-453276: Regulation of mitotic cell cycle |
Summary | |
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Symbol | NEK2 |
Name | NIMA-related kinase 2 |
Aliases | NLK1; NEK2A; RP67; PPP1R111; HsPK 21; protein phosphatase 1, regulatory subunit 111; NIMA (never in mitosis ...... |
Chromosomal Location | 1q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NEK2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | NEK2 |
Name | NIMA-related kinase 2 |
Aliases | NLK1; NEK2A; RP67; PPP1R111; HsPK 21; protein phosphatase 1, regulatory subunit 111; NIMA (never in mitosis ...... |
Chromosomal Location | 1q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NEK2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NEK2 |
Name | NIMA-related kinase 2 |
Aliases | NLK1; NEK2A; RP67; PPP1R111; HsPK 21; protein phosphatase 1, regulatory subunit 111; NIMA (never in mitosis ...... |
Chromosomal Location | 1q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NEK2 in various data sets.
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Points in the above scatter plot represent the mutation difference of NEK2 in various data sets.
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Summary | |
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Symbol | NEK2 |
Name | NIMA-related kinase 2 |
Aliases | NLK1; NEK2A; RP67; PPP1R111; HsPK 21; protein phosphatase 1, regulatory subunit 111; NIMA (never in mitosis ...... |
Chromosomal Location | 1q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NEK2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NEK2 |
Name | NIMA-related kinase 2 |
Aliases | NLK1; NEK2A; RP67; PPP1R111; HsPK 21; protein phosphatase 1, regulatory subunit 111; NIMA (never in mitosis ...... |
Chromosomal Location | 1q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NEK2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NEK2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NEK2 |
Name | NIMA-related kinase 2 |
Aliases | NLK1; NEK2A; RP67; PPP1R111; HsPK 21; protein phosphatase 1, regulatory subunit 111; NIMA (never in mitosis ...... |
Chromosomal Location | 1q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NEK2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NEK2 |
Name | NIMA-related kinase 2 |
Aliases | NLK1; NEK2A; RP67; PPP1R111; HsPK 21; protein phosphatase 1, regulatory subunit 111; NIMA (never in mitosis ...... |
Chromosomal Location | 1q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NEK2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NEK2 |
Name | NIMA-related kinase 2 |
Aliases | NLK1; NEK2A; RP67; PPP1R111; HsPK 21; protein phosphatase 1, regulatory subunit 111; NIMA (never in mitosis ...... |
Chromosomal Location | 1q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NEK2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NEK2 |
Name | NIMA-related kinase 2 |
Aliases | NLK1; NEK2A; RP67; PPP1R111; HsPK 21; protein phosphatase 1, regulatory subunit 111; NIMA (never in mitosis ...... |
Chromosomal Location | 1q32.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NEK2 collected from DrugBank database. |
Details on drugs targeting NEK2.
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