Summary | |
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Symbol | NELFB |
Name | negative elongation factor complex member B |
Aliases | KIAA1182; NELF-B; COBRA1; cofactor of BRCA1; negative elongation factor protein B; Negative elongation facto ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF06209 Cofactor of BRCA1 (COBRA1) |
Function |
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1. May be able to induce chromatin unfolding. |
Biological Process |
GO:0006354 DNA-templated transcription, elongation GO:0006368 transcription elongation from RNA polymerase II promoter GO:0019058 viral life cycle GO:0019080 viral gene expression GO:0019083 viral transcription GO:0032784 regulation of DNA-templated transcription, elongation GO:0032785 negative regulation of DNA-templated transcription, elongation GO:0034243 regulation of transcription elongation from RNA polymerase II promoter GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044033 multi-organism metabolic process GO:0046782 regulation of viral transcription GO:0048524 positive regulation of viral process GO:0050434 positive regulation of viral transcription GO:0050792 regulation of viral process GO:1903900 regulation of viral life cycle GO:1903902 positive regulation of viral life cycle |
Molecular Function | - |
Cellular Component |
GO:0008023 transcription elongation factor complex GO:0032021 NELF complex |
KEGG | - |
Reactome |
R-HSA-167242: Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-1643685: Disease R-HSA-112387: Elongation arrest and recovery R-HSA-167152: Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167200: Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-112382: Formation of RNA Pol II elongation complex R-HSA-113418: Formation of the Early Elongation Complex R-HSA-167158: Formation of the HIV-1 Early Elongation Complex R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-162906: HIV Infection R-HSA-162587: HIV Life Cycle R-HSA-167169: HIV Transcription Elongation R-HSA-167287: HIV elongation arrest and recovery R-HSA-5663205: Infectious disease R-HSA-162599: Late Phase of HIV Life Cycle R-HSA-167290: Pausing and recovery of HIV elongation R-HSA-167238: Pausing and recovery of Tat-mediated HIV elongation R-HSA-674695: RNA Polymerase II Pre-transcription Events R-HSA-73857: RNA Polymerase II Transcription R-HSA-75955: RNA Polymerase II Transcription Elongation R-HSA-6796648: TP53 Regulates Transcription of DNA Repair Genes R-HSA-167243: Tat-mediated HIV elongation arrest and recovery R-HSA-167246: Tat-mediated elongation of the HIV-1 transcript R-HSA-167172: Transcription of the HIV genome R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
---|---|
Symbol | NELFB |
Name | negative elongation factor complex member B |
Aliases | KIAA1182; NELF-B; COBRA1; cofactor of BRCA1; negative elongation factor protein B; Negative elongation facto ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NELFB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NELFB |
Name | negative elongation factor complex member B |
Aliases | KIAA1182; NELF-B; COBRA1; cofactor of BRCA1; negative elongation factor protein B; Negative elongation facto ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NELFB in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | NELFB |
Name | negative elongation factor complex member B |
Aliases | KIAA1182; NELF-B; COBRA1; cofactor of BRCA1; negative elongation factor protein B; Negative elongation facto ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NELFB in various data sets.
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Points in the above scatter plot represent the mutation difference of NELFB in various data sets.
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Summary | |
---|---|
Symbol | NELFB |
Name | negative elongation factor complex member B |
Aliases | KIAA1182; NELF-B; COBRA1; cofactor of BRCA1; negative elongation factor protein B; Negative elongation facto ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NELFB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NELFB |
Name | negative elongation factor complex member B |
Aliases | KIAA1182; NELF-B; COBRA1; cofactor of BRCA1; negative elongation factor protein B; Negative elongation facto ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NELFB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NELFB. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | NELFB |
Name | negative elongation factor complex member B |
Aliases | KIAA1182; NELF-B; COBRA1; cofactor of BRCA1; negative elongation factor protein B; Negative elongation facto ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NELFB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NELFB |
Name | negative elongation factor complex member B |
Aliases | KIAA1182; NELF-B; COBRA1; cofactor of BRCA1; negative elongation factor protein B; Negative elongation facto ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NELFB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NELFB |
Name | negative elongation factor complex member B |
Aliases | KIAA1182; NELF-B; COBRA1; cofactor of BRCA1; negative elongation factor protein B; Negative elongation facto ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NELFB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NELFB |
Name | negative elongation factor complex member B |
Aliases | KIAA1182; NELF-B; COBRA1; cofactor of BRCA1; negative elongation factor protein B; Negative elongation facto ...... |
Chromosomal Location | 9q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NELFB collected from DrugBank database. |
There is no record. |