Summary | |
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Symbol | NEURL3 |
Name | neuralized E3 ubiquitin protein ligase 3 |
Aliases | Lincr; LOC93082; neuralized homolog 3 (Drosophila) pseudogene; lung-inducible neuralized-related C3CH4 RING ...... |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF07177 Neuralized |
Function |
E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation. |
Biological Process | - |
Molecular Function |
GO:0004842 ubiquitin-protein transferase activity GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity GO:0061630 ubiquitin protein ligase activity GO:0061659 ubiquitin-like protein ligase activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | NEURL3 |
Name | neuralized E3 ubiquitin protein ligase 3 |
Aliases | Lincr; LOC93082; neuralized homolog 3 (Drosophila) pseudogene; lung-inducible neuralized-related C3CH4 RING ...... |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NEURL3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NEURL3 |
Name | neuralized E3 ubiquitin protein ligase 3 |
Aliases | Lincr; LOC93082; neuralized homolog 3 (Drosophila) pseudogene; lung-inducible neuralized-related C3CH4 RING ...... |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NEURL3 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | NEURL3 |
Name | neuralized E3 ubiquitin protein ligase 3 |
Aliases | Lincr; LOC93082; neuralized homolog 3 (Drosophila) pseudogene; lung-inducible neuralized-related C3CH4 RING ...... |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NEURL3 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | NEURL3 |
Name | neuralized E3 ubiquitin protein ligase 3 |
Aliases | Lincr; LOC93082; neuralized homolog 3 (Drosophila) pseudogene; lung-inducible neuralized-related C3CH4 RING ...... |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NEURL3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | NEURL3 |
Name | neuralized E3 ubiquitin protein ligase 3 |
Aliases | Lincr; LOC93082; neuralized homolog 3 (Drosophila) pseudogene; lung-inducible neuralized-related C3CH4 RING ...... |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NEURL3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NEURL3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | NEURL3 |
Name | neuralized E3 ubiquitin protein ligase 3 |
Aliases | Lincr; LOC93082; neuralized homolog 3 (Drosophila) pseudogene; lung-inducible neuralized-related C3CH4 RING ...... |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NEURL3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | NEURL3 |
Name | neuralized E3 ubiquitin protein ligase 3 |
Aliases | Lincr; LOC93082; neuralized homolog 3 (Drosophila) pseudogene; lung-inducible neuralized-related C3CH4 RING ...... |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NEURL3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | NEURL3 |
Name | neuralized E3 ubiquitin protein ligase 3 |
Aliases | Lincr; LOC93082; neuralized homolog 3 (Drosophila) pseudogene; lung-inducible neuralized-related C3CH4 RING ...... |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NEURL3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | NEURL3 |
Name | neuralized E3 ubiquitin protein ligase 3 |
Aliases | Lincr; LOC93082; neuralized homolog 3 (Drosophila) pseudogene; lung-inducible neuralized-related C3CH4 RING ...... |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NEURL3 collected from DrugBank database. |
There is no record. |