Summary | |
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Symbol | NEUROD1 |
Name | neuronal differentiation 1 |
Aliases | BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ...... |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Note=In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation (By similarity). Colocalizes with NR0B2 in the nucleus. |
Domain |
PF00010 Helix-loop-helix DNA-binding domain PF12533 Neuronal helix-loop-helix transcription factor |
Function |
Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). |
Biological Process |
GO:0001654 eye development GO:0001678 cellular glucose homeostasis GO:0001894 tissue homeostasis GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0002067 glandular epithelial cell differentiation GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0003002 regionalization GO:0003310 pancreatic A cell differentiation GO:0003312 pancreatic PP cell differentiation GO:0003326 pancreatic A cell fate commitment GO:0003329 pancreatic PP cell fate commitment GO:0003407 neural retina development GO:0006913 nucleocytoplasmic transport GO:0007050 cell cycle arrest GO:0007259 JAK-STAT cascade GO:0007263 nitric oxide mediated signal transduction GO:0007389 pattern specification process GO:0007423 sensory organ development GO:0007586 digestion GO:0009306 protein secretion GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009914 hormone transport GO:0009952 anterior/posterior pattern specification GO:0010669 epithelial structure maintenance GO:0010720 positive regulation of cell development GO:0010817 regulation of hormone levels GO:0015833 peptide transport GO:0019932 second-messenger-mediated signaling GO:0021537 telencephalon development GO:0021542 dentate gyrus development GO:0021543 pallium development GO:0021549 cerebellum development GO:0021761 limbic system development GO:0021766 hippocampus development GO:0022037 metencephalon development GO:0022600 digestive system process GO:0023019 signal transduction involved in regulation of gene expression GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030277 maintenance of gastrointestinal epithelium GO:0030900 forebrain development GO:0030902 hindbrain development GO:0031016 pancreas development GO:0031018 endocrine pancreas development GO:0032844 regulation of homeostatic process GO:0033500 carbohydrate homeostasis GO:0034284 response to monosaccharide GO:0035270 endocrine system development GO:0035881 amacrine cell differentiation GO:0035883 enteroendocrine cell differentiation GO:0042493 response to drug GO:0042593 glucose homeostasis GO:0042886 amide transport GO:0043010 camera-type eye development GO:0043388 positive regulation of DNA binding GO:0043583 ear development GO:0044057 regulation of system process GO:0044058 regulation of digestive system process GO:0045165 cell fate commitment GO:0045666 positive regulation of neuron differentiation GO:0045786 negative regulation of cell cycle GO:0046425 regulation of JAK-STAT cascade GO:0046426 negative regulation of JAK-STAT cascade GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048839 inner ear development GO:0048871 multicellular organismal homeostasis GO:0050708 regulation of protein secretion GO:0050769 positive regulation of neurogenesis GO:0050796 regulation of insulin secretion GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051101 regulation of DNA binding GO:0051169 nuclear transport GO:0051962 positive regulation of nervous system development GO:0060041 retina development in camera-type eye GO:0060249 anatomical structure homeostasis GO:0060729 intestinal epithelial structure maintenance GO:0060730 regulation of intestinal epithelial structure maintenance GO:0071156 regulation of cell cycle arrest GO:0071322 cellular response to carbohydrate stimulus GO:0071326 cellular response to monosaccharide stimulus GO:0071331 cellular response to hexose stimulus GO:0071333 cellular response to glucose stimulus GO:0072148 epithelial cell fate commitment GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0097050 type B pancreatic cell apoptotic process GO:0097696 STAT cascade GO:1902532 negative regulation of intracellular signal transduction GO:1904019 epithelial cell apoptotic process GO:1904035 regulation of epithelial cell apoptotic process GO:1904036 negative regulation of epithelial cell apoptotic process GO:1904892 regulation of STAT cascade GO:1904893 negative regulation of STAT cascade GO:2000674 regulation of type B pancreatic cell apoptotic process GO:2000675 negative regulation of type B pancreatic cell apoptotic process GO:2000677 regulation of transcription regulatory region DNA binding GO:2000679 positive regulation of transcription regulatory region DNA binding |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001085 RNA polymerase II transcription factor binding GO:0001102 RNA polymerase II activating transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0001105 RNA polymerase II transcription coactivator activity GO:0001159 core promoter proximal region DNA binding GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0008134 transcription factor binding GO:0033613 activating transcription factor binding GO:0046982 protein heterodimerization activity GO:0070888 E-box binding GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding |
Cellular Component |
GO:0005667 transcription factor complex GO:0044798 nuclear transcription factor complex GO:0090575 RNA polymerase II transcription factor complex |
KEGG | - |
Reactome |
R-HSA-1266738: Developmental Biology R-HSA-186712: Regulation of beta-cell development R-HSA-210745: Regulation of gene expression in beta cells R-HSA-210746: Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells |
Summary | |
---|---|
Symbol | NEUROD1 |
Name | neuronal differentiation 1 |
Aliases | BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ...... |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between NEUROD1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | NEUROD1 |
Name | neuronal differentiation 1 |
Aliases | BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ...... |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of NEUROD1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | NEUROD1 |
Name | neuronal differentiation 1 |
Aliases | BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ...... |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of NEUROD1 in various data sets.
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Points in the above scatter plot represent the mutation difference of NEUROD1 in various data sets.
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Summary | |
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Symbol | NEUROD1 |
Name | neuronal differentiation 1 |
Aliases | BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ...... |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NEUROD1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | NEUROD1 |
Name | neuronal differentiation 1 |
Aliases | BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ...... |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NEUROD1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NEUROD1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | NEUROD1 |
Name | neuronal differentiation 1 |
Aliases | BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ...... |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NEUROD1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | NEUROD1 |
Name | neuronal differentiation 1 |
Aliases | BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ...... |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of NEUROD1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | NEUROD1 |
Name | neuronal differentiation 1 |
Aliases | BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ...... |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between NEUROD1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | NEUROD1 |
Name | neuronal differentiation 1 |
Aliases | BHF-1; NeuroD; bHLHa3; MODY6; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD; ...... |
Chromosomal Location | 2q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting NEUROD1 collected from DrugBank database. |
There is no record. |